2012
DOI: 10.1111/j.1464-410x.2011.10777.x
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The management of transitional cell carcinoma (TCC) in a European regional renal transplant population

Abstract: Study Type – Therapy (prospective cohort) Level of Evidence 2a What's known on the subject? and What does the study add? In the West, transitional cell carcinoma (TCC) in renal transplant patients is uncommon, but aggressive. Conversely, it appears to be frequent in the Far East, necessitating aggressive surgical approaches such as prophylactic nephroureterectomy. There are few European case series to date. TCC in the present population was predominantly low‐grade and superficial, with no progression in patien… Show more

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Cited by 19 publications
(16 citation statements)
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“…Concerning bladder urothelial neoplasms in the present study, 28 cases of de novo BC have been retrospectively reviewed. BC incidence in the present study is 0.9%, which is in line with literature findings that ranges between 0.3 and 2% [4]. A recent meta-analysis of most actual and well-conducted available studies has been performed by Yan et al [10] to determine whether the overall standard incidence ratio (SIR) of BC is increased in RTRs compared to standard population.…”
Section: Discussionsupporting
confidence: 78%
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“…Concerning bladder urothelial neoplasms in the present study, 28 cases of de novo BC have been retrospectively reviewed. BC incidence in the present study is 0.9%, which is in line with literature findings that ranges between 0.3 and 2% [4]. A recent meta-analysis of most actual and well-conducted available studies has been performed by Yan et al [10] to determine whether the overall standard incidence ratio (SIR) of BC is increased in RTRs compared to standard population.…”
Section: Discussionsupporting
confidence: 78%
“…When stratified by ethnicity, the SIR for BC was 2.00 (95% CI 1.51-2.65, p = 0.001) among Europeans and much higher (14.74) among Asian RTRs (95% CI 3.66-59.35, p < 0.001) suggesting the presence of ethnicity-based differences [10]. The marked difference in incidence of TCC in RTRs in the far east compared with Western countries could be due, in part, to the use of Chinese herbs such as rhubarb and aristolochic acid, which have been associated with an increased cancer risk [4]. These substances are frequently used in the traditional Chinese medicine as an aid to the digestion and for weight reduction.…”
Section: Discussionmentioning
confidence: 95%
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