The Mandate for a Global “One Health” Approach to Antimicrobial Resistance Surveillance

Thakur, Siddhartha; Gray, Gregory C.

doi:10.4269/ajtmh.18-0973

Cited by 56 publications

(49 citation statements)

References 19 publications

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“…Antimicrobial resistance (AMR) is a global health threat [ 1 ] that requires a “One Health” approach [ 2 – 4 ]. The “One Health” approach recognizes that the health of people is closely connected to the health of animals and the environment [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Bibliometric analysis of global research output on antimicrobial resistance in the environment (2000–2019)

Sweileh

Mansour

2020

glob health res policy

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Background: Antimicrobial resistance (AMR) is a global health threat that requires a "One Health" approach. Of the One Health triad, the environmental component is the most dynamic and most neglected. Therefore, the objective of the current study was to assess and analyze global research activity on AMR in the environment. Methods: This was a bibliometric descriptive study of publications on AMR in the environment. Publications were retrieved using SciVerse Scopus for the study period from 2000 to 2019. The search query was developed using terms and phrases related to the topic. The retrieved publications were analyzed for specific bibliometric indicators including annual growth, citation analysis, key players, research output for each world regions, research themes, and occurrences of different drug classes of antimicrobials. Visualization maps including research collaboration were created using VOSviewer program. The Hirsch (h) index was used to assess scientific impact. Results: There were 2611 research articles based on the implemented research query. The retrieved documents had an average of 22 citations per document and an h-index of 122. The annual number of publications showed a steep increase from 2011 to 2019. The major research themes in the field were (1) dissemination and abundance of antibiotic-resistant genes and (2) detection of bacterial strains or antibiotic residues in various environmental isolates. The bulk of the retrieved articles (n = 899; 34.4%) originated from the European region. China led with 598 (22.9%) documents. Four of the top 10 active institutions were in China. The top 10 active countries had relatively inadequate international research collaboration. The most commonly encountered antibiotic drug classes in the retrieved articles were penicillin/cephalosporin (n = 1152 occurrences). The most frequently encountered pathogen in the retrieved publications was E. coli (n = 666). The Science of the Total Environment journal was the most prolific journal with 139 (5.3%) publications. Conclusion: Scientific literature on the AMR in the environment has witnessed a steep growth lately with a leading role of China and Chinese institutions. Data on AMR in the environment need to be collected from all world regions including the Eastern Mediterranean and African regions through research collaboration and funding of research in this field.

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Section: Introductionmentioning

confidence: 99%

Bibliometric analysis of global research output on antimicrobial resistance in the environment (2000–2019)

Sweileh

Mansour

2020

glob health res policy

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“…A systematic review including 19 observational studies from 11 different countries indicated that Methicillin-resistant Staphylococcus aureus (MRSA), multi-resistant Acinetobacter baumannii (MRAB), and bacteria producing extended-spectrum β-lactamase (ESBL) costed $916.61–62908.00, $4644.00–98575.00, and $2824.14–30093.00 per person, respectively (Ling et al, 2017). As predicted, by 2050 there will be more than 10 million deaths per year (Thakur and Gray, 2019) and a cumulative cost to global economic output of 100 trillion USD due to the rise of AMR (O’Neill, 2016). A study indicated that the increase in AMR burden correlated with a 65% increase in human antimicrobial consumption between 2000 and 2015 in 76 countries (Klein et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effectiveness of Clinical Pharmacists’ Consultation in the Treatment of Infectious Diseases: A Single-Arm, Prospective Cohort Study

et al. 2019

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Background: With the implementation of Antimicrobial Stewardship Program, clinical pharmacists’ consultation (CPC) for infectious diseases (ID) is gradually adopted by many hospitals in China. We conducted a cohort study to evaluate the effectiveness of CPC in ID treatment on patient outcomes and potential determinants. Methods: Based on a registry database, a prospective cohort study was conducted in Guizhou Provincial People’s Hospital. The main exposure factor was whether clinician adopted the suggestion from clinical pharmacist. The outcome was effective response rate (ERR) of ID patients. The variables associated with the outcome (e.g., age, gender, severity of infection, liver function, and kidney function) were also prospectively recorded. A multilevel model was performed to analyze the factors related to ERR. Results: A total of 733 ID inpatients were included in the final analysis according to the predesigned inclusion and exclusion criteria. The proportion of clinical pharmacists’ suggestions adopted by clinicians and ERR were 88.13 and 69.03%, respectively. Significant data aggregation ( P < 0.05) for individuals at the level of department was observed. According to the two-level variance component model, liver dysfunction ( Adjusted Odds Ratio (AOR) = 0.649, 95% Credible Interval ( CI) : 0.432–0.976), severity of infection ( AOR = 0.602, 95% CI : 0.464–0.781), and adopting the suggestion from pharmacist ( AOR = 1.738, 95% CI : 1.028–2.940) had significant association with ERR. Conclusion: Our study suggests that the effect of CPC on ID treatment is significant. The policy/decision makers or hospital managers should be cognizant of the critical value of clinical pharmacists in ID treatment.

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“…This specific result will be hard to achieve when using short reads. AMR genes found in the irrigation water sample (GLASS -https://www.who.int/glass/en/) use the resources of the CDC, USDA, FDA, and WHO to monitor and report the prevalence of and distribute regulatory guidance on antimicrobial resistance in pathogenic and commensal bacteria in food and food animals (52,55). Our pipeline could be an important screening tool to enhance future testing.…”

Section: Discussionmentioning

confidence: 99%

Precision long-read metagenomics sequencing for food safety by detection and assembly of Shiga toxin-producingEscherichia coliin irrigation water

Maguire

Kase

Roberson

et al. 2020

Preprint

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Shiga toxin-producing Escherichia coli (STEC) contamination of agricultural water might be an important factor to recent foodborne illness and outbreaks involving leafy greens. Whole genome sequencing generation of closed bacterial genomes plays an important role in source tracking. We aimed to determine the limits of detection and classification of STECs by qPCR and nanopore sequencing using enriched irrigation water artificially contaminated with E. coli O157:H7 (EDL933). We determined the limit of STEC detection by qPCR to be 30 CFU/reaction, which is equivalent to 105 CFU/ml in the enrichment. By using Oxford Nanopore's EPI2ME WIMP workflow and de novo assembly with Flye followed by taxon classification with a k-mer analysis software (Kraken), E. coli O157:H7 could be detected at 103 CFU/ml (68 reads) and a complete fragmented E. coli O157:H7 metagenome-assembled genome (MAG) was obtained at 105-108 CFU/ml. Using a custom script to extract the E. coli reads, a completely closed MAG was obtained at 107-108 CFU/ml and a complete, fragmented MAG was obtained at 105-106 CFU/ml. In silico virulence detection for E. coli MAGs for 105-108 CFU/ml showed that the virulotype was indistinguishable from the spiked E. coli O157:H7 strain. We further identified the bacterial species in the un-spiked enrichment, including antimicrobial resistance genes, which could have important implications to food safety. We propose this workflow could be used for detection and complete genomic characterization of STEC from a complex microbial sample and could be applied to determine the limit of detection and assembly of other foodborne bacterial pathogens.

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The Mandate for a Global “One Health” Approach to Antimicrobial Resistance Surveillance

Cited by 56 publications

References 19 publications

Bibliometric analysis of global research output on antimicrobial resistance in the environment (2000–2019)

Bibliometric analysis of global research output on antimicrobial resistance in the environment (2000–2019)

Evaluation of the Effectiveness of Clinical Pharmacists’ Consultation in the Treatment of Infectious Diseases: A Single-Arm, Prospective Cohort Study

Precision long-read metagenomics sequencing for food safety by detection and assembly of Shiga toxin-producingEscherichia coliin irrigation water

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