The manufacture and characterisation of hot-melt extruded enteric tablets

Andrews, Gavin; Jones, David S.; Diak, Osama Abu; McCoy, Colin; Watts, Alan B.; McGinity, James W.

doi:10.1016/j.ejpb.2007.11.001

Cited by 67 publications

(39 citation statements)

References 26 publications

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“…XRPD patterns confirmed the amorphous nature of Eudragit EPO whilst TCP remained crystalline across all the tested samples. XRPD patterns of both HME produced filaments and 3D printed tablets indicated the presence of intensity peaks at (2θ)= 7.9, 15 (Andrews et al, 2008;Bruce et al, 2005) for 5-ASA, (2θ)= 14.7, 17.6 for prednisolone (Nishiwaki et al, 2009;Sabzevari et al, 2013) and (2θ)= 7, 12 for theophylline. This suggests that a 14 fraction of these drugs remained in the crystalline form in filament and 3D printed tablets.…”

Section: Resultsmentioning

confidence: 99%

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Sadia

Sośnicka

Arafat

et al. 2016

International Journal of Pharmaceutics

273

147

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Abstract*Corresponding author: MAlbedAlhnan@uclan.ac.uk This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with various model drugs. It investigates the addition of nonmelting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of i) the nature of filler, ii) compatibility with the gears of the 3D printer and, and iii) polymer: filler ratio on the 3D printing process. A specially developed filament based on pharmaceutically approved methacrylic polymer (Eudragit E) and thermally stable filler, TCP (tribasic calcium phosphate) was optimised. Four model drugs (with different physicochemical properties were included into ready-to-use mechanically stable tablets with immediate release properties. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135 o C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet. Following the two thermal processes (hot melt extrusion (HME) and fused deposition modelling (FDM) 3D printing), drug contents were 94.22%, 88.53%, 96.51% and 93.04% for 5-ASA, captopril, theophylline and prednisolone respectively. XRPD indicated that a fraction of 5-ASA, theophylline and prednisolone remained in the crystalline form whilst captopril was in amorphous form. By combining the advantages of thermally stable pharmaceutically approved polymers and fillers, this unique approach provides a low cost production method for on demand manufacturing of individualised dosage forms.

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Section: Resultsmentioning

confidence: 99%

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Sadia

Sośnicka

Arafat

et al. 2016

International Journal of Pharmaceutics

273

147

View full text Add to dashboard Cite

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“…3) In general, annealing increases the density within the polymer and decreases the rate of creep or stress relaxation at temperatures below the Tg. [4][5][6] These changes tend to improve the dimensional stability of the polymer, as well as remove any residual stresses, strains, or defects that may have occurred during processing. Annealing generally produces polymers which display higher moduli and tend to be more brittle than unannealed polymers.…”

mentioning

confidence: 99%

Thermal Treating of Acrylic Matrices as a Tool for Controlling Drug Release

Hasanzadeh

Ghaffari

Monajjemzadeh

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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The purpose of the present study was to investigate the effect of thermal-treating on the release of ibuprofen from the granules prepared using aqueous dispersions of Eudragit. To accomplish this goal, different formulations were prepared using wet granulation method containing two different types of Eudragit aqueous dispersions, RS30D, RL30D and Avicel as filler. Tablets were prepared using direct compression method. The prepared tablets were thermally treated at 50 and 70°C for 24 h. The drug release from tablets was assessed before and after thermal-treating. The results of release study showed that, thermally-treating the tablets at the temperatures higher than glass transition temperature (Tg) of the polymer can decrease the drug release from matrices. For mechanistic evaluation of the effect of thermal-treating, powder X-ray diffraction (XPD), scanning electron microscopy (SEM), differential scanning calorimeter (DSC), Fourier transform infrared (FT-IR) and helium pycnometer have been employed. The SEM graphs showed that the tablets have smoother surface with less porosity after thermal-treating. FT-IR spectra showed no change in the spectrum of thermally-treated tablet compared to control. In DSC graphs, no crystalline change was seen in the heat-treated samples of ibuprofen tablets, but decreased and widened peak size were related to the probable formation of solid solution of ibuprofen in Eudragit matrix. The results of helium pycnometer showed a significant decrease in the total porosity of some heat-treated samples. This study revealed the importance of thermal treating on the drug release from sustained release tablets containing Eudragit polymer.

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“…The optimal concentration of citric acid was 17 %. 5-aminosalicylic acid was employed as the model active ingredient (Andrews et al, 2008).…”

Section: Matrix Polymeric Systemsmentioning

confidence: 99%