Thermal Treating of Acrylic Matrices as a Tool for Controlling Drug Release

Abstract

The purpose of the present study was to investigate the effect of thermal-treating on the release of ibuprofen from the granules prepared using aqueous dispersions of Eudragit. To accomplish this goal, different formulations were prepared using wet granulation method containing two different types of Eudragit aqueous dispersions, RS30D, RL30D and Avicel as filler. Tablets were prepared using direct compression method. The prepared tablets were thermally treated at 50 and 70°C for 24 h. The drug release from tablets was assessed before and after thermal-treating. The results of release study showed that, thermally-treating the tablets at the temperatures higher than glass transition temperature (Tg) of the polymer can decrease the drug release from matrices. For mechanistic evaluation of the effect of thermal-treating, powder X-ray diffraction (XPD), scanning electron microscopy (SEM), differential scanning calorimeter (DSC), Fourier transform infrared (FT-IR) and helium pycnometer have been employed. The SEM graphs showed that the tablets have smoother surface with less porosity after thermal-treating. FT-IR spectra showed no change in the spectrum of thermally-treated tablet compared to control. In DSC graphs, no crystalline change was seen in the heat-treated samples of ibuprofen tablets, but decreased and widened peak size were related to the probable formation of solid solution of ibuprofen in Eudragit matrix. The results of helium pycnometer showed a significant decrease in the total porosity of some heat-treated samples. This study revealed the importance of thermal treating on the drug release from sustained release tablets containing Eudragit polymer.

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

“…The bioscaffolds that have been subjected to thermal treatment present smoother surfaces with fewer fractures and less porosity ( Figure 6 ). These results were consistent with other studies [ 30 , 59 ].…”

“…A higher salt concentration led to an increase in the porous structure, resulting in an irregular and spongier shape [ 27 ]. However, the total porosity of the bioscaffolds slightly decreased after the thermal treatment [ 29 , 30 , 59 ]. The graph clearly shows that non-thermal treated bioscaffolds with the highest concentration (10 g/L) of NaCl possessed the highest porosity (94%), whereas there was a reduction of porosity (92%) for thermal treated bioscaffolds with the same concentration of NaCl.…”

Physicochemical analysis and nonisothermal kinetic study of sertraline–lactose binary mixtures

“…These methods have been widely applied for the evaluation of possible interactions in pharmaceutical formulation since 1970 [ 3 , 4 ]. Thermal methods have been applied in different pharmaceutical fields such as selection of a suitable salt form, evaluating the phase-diagrams, active pharmaceutical ingredient-excipient interactions, and to predict the physical changes on processing or during drug storage [ 5 , 6 ]. Calorimetry is a fundamental tool used in pharmaceutical industries which measures heat effects related to phase transition and chemical reaction as a function of temperature.…”

Investigation of Possible Maillard Reaction Between Acyclovir and Dextrose upon Dilution Prior to Parenteral Administration

“…Thus, physicochemical evaluations have been performed on solid materials in a concentrated condition to force the chemical reaction to take place. DSC DSC has been widely used in monitoring the presence of incompatibility in pharmaceutical preparations (22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Compatibility data should be interpreted carefully as lots of deviations from principal laws can be explained.…”