The Many Faces of Hemolysis

Cook, Lynda

doi:10.1097/nan.0000000000000491

Journal of Infusion Nursing

2023

DOI: 10.1097/nan.0000000000000491

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The Many Faces of Hemolysis

Lynda Cook¹

Abstract: Hemolysis is a problem associated with a variety of red cell pathologies and physiologies not limited to the transfusion of cells. Various pathways lead to the observed outcomes when a hemolytic event occurs. Each event, and the pathway it follows, is based on characteristics of the red cell, the location in which the hemolysis occurs, and the interaction of the immune system. The severity of an event can be predicted with the knowledge of how these 3 factors interface. Although not all hemolytic events are al… Show more

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2024

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Cited by 3 publications

References 48 publications

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Hemocompatibility studies in nanotoxicology: Hemolysis or eryptosis? (A review)

Tkachenko

2024

Toxicology in Vitro

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Hemocompatibility studies in nanotoxicology: Hemolysis or eryptosis? (A review)

Tkachenko

2024

Toxicology in Vitro

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The association of manganese levels with red cell distribution width: A population-based study

Dai,

Sun,

Lan

et al. 2024

PLoS ONE

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Objectives Experimental and acute exposure studies imply that manganese affects red blood cell production. Nevertheless, the association between environmental exposure and red blood cell distribution width (RDW) has yet to be explored. This research sought to assess the correlation between blood manganese levels and RDW within the general population of the United States. Materials and methods Employing weighted multiple linear regression models, data from the 2011–2018 National Health and Nutrition Examination Survey (NHANES) were utilized to assess the correlation between manganese levels in the blood and RDW. Restricted cubic spline plots and two-piecewise linear regression models were also employed. Result The analysis included a total of 15882 participants in which we determined an independent positive relationship between blood manganese levels and RDW among participants(β = 0.079, P<0.001). Moreover, we identified a J-shaped association between blood manganese levels and RDW in total participants (inflection point for blood manganese: 7.32 ug/L) and distinct subgroups following adjusted covariates. Women exhibited a more pronounced association, even after controlling for adjusted covariates. Conclusions We determined a J-shaped relationship between blood manganese levels and RDW with an inflection point at 7.32 ug/L for blood manganese. Nevertheless, fundamental research and large sample prospective studies are needed to determine the extent to which blood manganese levels correlate with RDW.

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The effect of inhalation of nitric oxide (II) on the concentration of cell-free hemoglobin in hemolysis. Experimental research

Bautin,

Chomahashvili,

Radovskiy

et al. 2024

Transl. med. (Print)

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Background. Hemolysis is a pathological condition accompanied by the release of hemoglobin (Hbf) into the plasma, which has adverse effects. Intravascular hemolysis occurs in various diseases, and also complicates the postoperative period of surgical interventions using cardiopulmonary bypass. Objective. In an animal experiment, to study the effect of inhalation of nitric oxide (NO) on the cell-free hemoglobin (Hbf) concentration. Methods. The study included 10 pigs, which were randomized into two groups: control (n = 5) and experimental (n = 5). After induction of anesthesia and tracheal intubation, intravascular hemolysis was simulated in all animals by intravenous administration of Hbf. After modeling hemolysis, the animals of the experimental group were inhaled with NO at a dosage of 80 ppm. Animals from the control group did not receive NO. The dynamics of Hbf and methemoglobin were evaluated for 6 hours. Then euthanasia was performed. Results. The Hbf level in the experimental group was statistically significantly lower compared to the control group after 30 minutes (1.2 (1; 1.3) g/l vs. 1.7 (1.6; 1.9) g/l, p = 0.047), 60 minutes (0.9 (0.9; 1) g/l vs. 1.24 (1.2; 1.5) g/l, p = 0.046) and 90 minutes (0.7 (0.7; 0.8) g/l vs. 0.94 (0.9; 1.2) g/l, p = 0.035) after administration of Hbf. The level of methemoglobin in the experimental group was statistically significantly higher than in the control group throughout the study, but did not reach a toxic concentration of 5 %. Conclusion. Inhalation of NO at a dosage of 80 ppm reduces the level of Hbf. Inhalation of NO at a dosage of 80 ppm increases the level of methemoglobin within safe values.

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The Many Faces of Hemolysis

Cited by 3 publications

References 48 publications

Hemocompatibility studies in nanotoxicology: Hemolysis or eryptosis? (A review)

Hemocompatibility studies in nanotoxicology: Hemolysis or eryptosis? (A review)

The association of manganese levels with red cell distribution width: A population-based study

The effect of inhalation of nitric oxide (II) on the concentration of cell-free hemoglobin in hemolysis. Experimental research

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