The many forms of bipolar disorder: a modern look at an old illness

Thomas, Pierre

doi:10.1016/j.jad.2004.01.001

Cited by 46 publications

(37 citation statements)

References 34 publications

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“…Bipolar disorder (BPD) is characterized by periods of depression interspersed with (usually shorter) periods of mania or hypomania (Thomas, 2004). Much of the work investigating the role of myo-inositol in psychiatric disorders has focused on BPD.…”

Section: Bipolar Disordermentioning

confidence: 99%

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

Kim

McGrath

Silverstone

2005

Human Psychopharmacology

119

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Myo-inositol is an important part of the phosphatidylinositol second messenger system (PI-cycle). Abnormalities in nerve cell myo-inositol levels and/or PI-cycle regulation has been suggested as being involved in the pathophysiology and/or treatment of many psychiatric disorders including bipolar disorder, major depressive disorder, panic disorder, obsessive-compulsive disorder, eating disorders and schizophrenia. This review examines the metabolism and biochemical importance of myo-inositol and the PI-cycle. It relates this to the current in vivo evidence for myo-inositol and PI-cycle involvement in these psychiatric disorders, particularly focusing upon the magnetic resonance spectroscopy (MRS) findings in patient studies to date. From this review it is concluded that while the evidence suggests probable relevance to the pathophysiology and/or treatment of bipolar disorder, there is much less support for a significant role for the PI-cycle or myo-inositol in any other psychiatric disorder. More definitive investigation is required before PI-cycle dysfunction can be considered specific to bipolar disorder.

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Section: Bipolar Disordermentioning

confidence: 99%

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

Kim

McGrath

Silverstone

2005

Human Psychopharmacology

119

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“…Thus, the clinical relevance of these findings remains uncertain. Nevertheless, as has been described for sub-threshold psychosis symptoms , research suggests that expressions of mania outside the realm of clinical disorder have a distribution in the general population (Akiskal, 2003, Krabbendam et al, 2004 and that sub-threshold expressions of mania show continuity with clinical diagnoses of mania and thus bipolar disorder (Regeer et al, 2006, Thomas, 2004.…”

Section: Does Cannabis Use Induce Mania Symptoms Specifically?mentioning

confidence: 95%

Cannabis Use and Mania Symptoms: a Systematic Review and Meta-analysis

Gibbs

Winsper

Marwaha

et al. 2015

European Psychiatry

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(2015) Cannabis use and mania symptoms : a systematic review and meta-analysis. Journal of Affective Disorders, Volume 171 . pp. 39-47. Permanent WRAP url:http://wrap.warwick.ac.uk/64733 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work of researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-forprofit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Publisher statement: NOTICE: this is the author's version of a work that was accepted for publication in Journal of Affective Disorders. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in http://dx.doi.org/10.1016/j.jad.2014.09.016 A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP url' above for details on accessing the published version and note that access may require a subscription. 2 Background: Whilst cannabis use appears to be a causal risk factor for the development of schizophrenia-related psychosis, associations with mania remain relatively unknown. This review aimed to examine the impact of cannabis use on the incidence of manic symptoms and on their occurrence in those with pre-existing bipolar disorder Methods: A systematic review of the scientific literature using the PRISMA guidelines.PsychINFO, Cochrane, Scopus, Embase and MEDLINE databases were searched for prospective studies.Results: Six articles met inclusion criteria. These sampled 2,391 individuals who had experienced mania symptoms. The mean length of follow up was 3.9 years.Studies support an association between cannabis use and the exacerbation of manic symptoms in those with previously diagnosed bipolar disorder. Furthermore, a meta-analysis of two studies suggests that cannabis use is associated with an approximately 3-fold (Odds Ratio: 2.97; 95% CI: 1.80 to 4.90) increased risk for the new onset of manic symptoms. Limitations:We were only able to identify a small number of studies of variable quality, thus our conclusions remain preliminary. Conclusions:Our findings whilst tentative, suggest that cannabis use may worsen the occurrence of manic symptoms i...

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“…In addition, misdiagnosis can lead to ineffective treatment or treatment which produces even more harmful effects. For example, misdiagnosis of bipolar disorder as schizophrenia has been found to be associated with increased risk of attempted suicide 35 , longer hospitalisation 7 and serious psychological, legal and financial problems 36 . In addition, misdiagnosis has a number of socioeconomic consequences including high medical costs, absence from work and negative effects on family and relationships 37 .…”

Section: The Importance Of Early Diagnosismentioning

confidence: 99%

Testes sanguíneos de biomarcadores para diagnóstico e tratamento de desordens mentais: foco em esquizofrenia

Bahn¹,

Schwarz

Harris

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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A descoberta e a aplicação clínica de biomarcadores para desordens mentais são confrontadas com muitos desafios. Em geral, os atuais métodos de descoberta e validação de biomarcadores não produziram os resultados que foram inicialmente aguardados depois da finalização do Projeto Genoma Humano. Isso se deve principalmente à falta de processos padronizados conectando a descoberta de marcadores com tecnologias para a validação e a tradução para uma plataforma que ofereça precisão e fácil uso em clínica. Como consequência, a maior parte dos psiquiatras e praticantes em geral são relutantes em aceitar que testes de biomarcadores pode suplementar ou substituir os métodos de diagnóstico utilizados baseados em entrevista. Apesar disso, agências regulatórias concordam agora que melhoras nos correntes métodos são essenciais. Além disso, essas agências estipularam que biomarcadores são importantes para o desenvolvimento de futuras drogas e iniciaram esforços no sentido de modernizar métodos e técnicas para suportar esses esforços. Aqui revisamos os desafios encontrados por essa tentativa do ponto de vista de psiquiatras, praticantes em geral, agências reguladoras e cientistas de biomarcadores. Também descrevemos o desenvolvimento de um novo teste sanguíneo molecular para esquizofrenia como um primeiro passo a esse objetivo.

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The many forms of bipolar disorder: a modern look at an old illness

Cited by 46 publications

References 34 publications

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

Cannabis Use and Mania Symptoms: a Systematic Review and Meta-analysis

Testes sanguíneos de biomarcadores para diagnóstico e tratamento de desordens mentais: foco em esquizofrenia

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