The MAPKKK Mekk1 regulates the expression of <i>Turandot</i> stress genes in response to septic injury in <i>Drosophila</i>

Brun, Sylvain; Vidal, Sheila; Spellman, Paul T.; Takahashi, Kuniaki; Tricoire, Hervé; Lemaître, Bruno

doi:10.1111/j.1365-2443.2006.00953.x

Cited by 84 publications

(74 citation statements)

References 40 publications

(60 reference statements)

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“…The JAK/STAT signaling pathway is activated by an extracellular protein ligand Upd3 and induces gene expression of complementlike protein and stress protein Turandot (Brun et al, 2006;Agaisse and Perrimon, 2004;Lagueux et al, 2000). This pathway is thought to participate in antiviral response (Dostert et al, 2005).…”

Section: Exon31mentioning

confidence: 99%

A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

Tanaka

Ishibashi

Fujita

et al. 2008

Insect Biochemistry and Molecular Biology

324

348

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Section: Exon31mentioning

confidence: 99%

A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

Tanaka

Ishibashi

Fujita

et al. 2008

Insect Biochemistry and Molecular Biology

324

348

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“…Turandot are Drosophila-specific genes of unknown function that are induced by various stress conditions, especially by septic injury (26,27). The transcriptional regulation of these genes is complex, with additional inputs from both the Imd and MAPK (mitogen-activated protein kinase) pathways (90).…”

Section: Interactions Between Toll and Imd Pathwaysmentioning

confidence: 99%

The Host Defense of Drosophila melanogaster

Lemaître

Hoffmann

2007

Annu. Rev. Immunol.

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2,944

3,089

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To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense reactions, many of which are shared with higher organisms. These reactions include the use of physical barriers together with local and systemic immune responses. First, epithelia, such as those beneath the cuticle, in the alimentary tract, and in tracheae, act both as a physical barrier and local defense against pathogens by producing antimicrobial peptides and reactive oxygen species. Second, specialized hemocytes participate in phagocytosis and encapsulation of foreign intruders in the hemolymph. Finally, the fat body, a functional equivalent of the mammalian liver, produces humoral response molecules including antimicrobial peptides.Here we review our current knowledge of the molecular mechanisms underlying Drosophila defense reactions together with strategies evolved by pathogens to evade them.

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“…These peptides are induced by the MEKK pathway (Brun et al 2006) and are also induced in hop Tum-l and Nurf301 mutants (Kwon et al 2008). Turandot peptides are secreted into the hemolymph after stress induction such as heat shock or oxidative stress and may act in a similar way to heat-shock proteins (Ekengren and Hultmark 2001).…”

Section: Ex1mentioning

confidence: 99%

Role of Elongator Subunit Elp3 in Drosophila melanogaster Larval Development and Immunity

et al. 2011

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The Elongator complex has been implicated in several cellular processes, including gene expression and tRNA modification. We investigated the biological importance of the Elp3 gene in Drosophila melanogaster. Deletion of Elp3 results in larval lethality at the pupal stage. During early development, larval growth is dramatically impaired, with progression to the third instar delayed for $24 hr, and pupariation occurring only at day 14 after egg laying. Melanotic nodules appear after 4 days. Microarray analysis shows that stress response genes are induced and ecdysone-induced transcription factors are severely repressed in the mutant. Interestingly, the phenotypes of Elp3 flies are similar to those of flies lacking the domino gene, encoding a SWI/SNF-like ATP-dependent chromatin-remodeling enzyme. Indeed, the gene expression profiles of these mutants are also remarkably similar. Together, these data demonstrate that Drosophila Elp3 is essential for viability, normal development, and hematopoiesis and suggest a functional overlap with the chromatin remodeler Domino.

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The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila

Abstract: Septic injury triggers a rapid and widespread response in

Cited by 84 publications

References 40 publications

A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

The Host Defense of Drosophila melanogaster

Role of Elongator Subunit Elp3 in Drosophila melanogaster Larval Development and Immunity

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