The marmoset as a model for the study of primate parental behavior

Saito, Atsuko

doi:10.1016/j.neures.2014.12.011

Cited by 33 publications

(22 citation statements)

References 126 publications

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“…Thus, just as active exploration of natural landscapes by rats led to the discovery of place cells and grid cells, the core building blocks of circuits for spatial cognition (O'Keefe and Dostrovsky, 1971), studies of marmosets exploring their social landscape may lead to similarly fundamental insights into social brain function. While it is possible that some of the resemblance is only superficial, such as cooperative parenting (Saito, 2015), the extent to which shared social behaviors are supported by homologous neural mechanisms remains an empirical question.…”

Section: Introductionmentioning

confidence: 99%

Marmosets: A Neuroscientific Model of Human Social Behavior

Miller

Freiwald

Leopold

et al. 2016

Neuron

281

235

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The common marmoset (Callithrix jacchus) has garnered interest recently as a powerful model for the future of neuroscience research. Much of this excitement has centered on the species’ reproductive biology and compatibility with gene editing techniques, which together have provided a path for transgenic marmosets to contribute to the study of disease as well as basic brain mechanisms. In step with technical advances is the need to establish experimental paradigms that optimally tap into the marmosets’ behavioral and cognitive capacities. While conditioned task performance of a marmoset can compare unfavorably with rhesus monkey performance on conventional testing paradigms, marmosets’ social cognition and communication are more similar to that of humans. For example, marmosets are amongst only a handful of primates that, like humans, routinely pair bond and care cooperatively for their young. They are also notably pro-social and exhibit social cognitive abilities, such as imitation, that are rare outside of the Apes. In this review, we describe key facets of marmoset natural social behavior and demonstrate that emerging behavioral paradigms are well suited to isolate components of marmoset cognition that are highly relevant to humans. These approaches generally embrace natural behavior and communication, which has been rare in conventional primate testing, and thus allow for a new consideration of neural mechanisms underlying primate social cognition and communication. We anticipate that through parallel technical and paradigmatic advances, marmosets will become an essential model of human social behavior, including its dysfunction in nearly all neuropsychiatric disorders.

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Section: Introductionmentioning

confidence: 99%

Marmosets: A Neuroscientific Model of Human Social Behavior

Miller

Freiwald

Leopold

et al. 2016

Neuron

281

235

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show abstract

“…However, doubtless the utilization in non-human primates is an essential step for AIE dots to advance clinically. Non-human primates with a strong homology and similarity of organizational structure and physiological functions to human beings 30,31 have been considered to be ideal laboratory animal models for the studies of life science 32,33 and pre-clinical studies of new drugs 34 . The special columnar, modular and laminar structure of the cortex in non-human primates demonstrates a closer metabolic coupling between neurons, glial cells 35 , and cerebral vasculature 36,37 , and may reflect the cytoarchitectonic and functional features of the cortex 38 , which is distinguished from the cortex of rodents.…”

Section: Mainmentioning

confidence: 99%

Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

Feng

Bai

et al. 2020

Preprint

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Booming AIE universe has set off an upsurge in recent years, driving much innovation in academic, industrial and medical world. Superb reliability and biocompatibility equip AIE dots with tremendous potential for fluorescence bioimaging and even clinical translation. The utilization on non-human primates imaging are vital for AIE dots assisted clinical theranostics, which still remains unexplored yet. Additionally, fluorescence bioimaging in second near-infrared window (NIR-II, 900-1700 nm) is widely recognized as an effective technology for deep-penetration mammals optical imaging. Here, we designed a novel AIEgen with a large molar extinction coefficient of ~5×104 mM−1 cm−1 at ~770 nm and the PEGylated AIE dots possessed an extremely high NIR-II photoluminescence quantum yield (PLQY) as 13.6%, exhibiting bright fluorescence beyond 1100 nm and even 1500 nm (near-infrared IIb, NIR-IIb). Assisted by the AIE dots, large-depth cerebral vasculature (beyond 600 μm) as well as real-time blood flowing were monitored through the skull and high-spatial-frequency non-invasive NIR-IIb (beyond 1500 nm) imaging gave a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of AIE dots from the body was demonstrated. It was the first attempt for AIE dots assisted NIR-II fluorescence imaging in non-human primates and we wished this work could promote the development of AIE dots for clinical application.

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“…Marmosets are relatively small for a primate, weighing only approximately 400 g. As a result, it has been possible to develop techniques to record the activity of single neurons in freely moving marmosets (Eliades and Wang, ; Roy and Wang, ). This approach has opened the door to exploring the neural processes underlying natural behaviors in the primate repertoire, such as in vocal communication (Eliades and Wang, ; Miller et al, ; Eliades and Miller, ), and can readily be applied to a broader range of behaviors, including foraging, visual perception, development, and social cognition (Santos and Hauser, ; Voelkl and Huber, ; Burkart and Heschl, ; Chow et al, ; Walker et al, ), among many other facets of the primate behavioral repertoire that emerge under more naturalistic conditions (Cavanaugh et al, ; Mustoe et al, ; Saito, ). The lissencephalic (smooth) cortex of marmosets is advantageous because nearly all cortical substrates are on the surface of the brain, just below the skull.…”

Section: Marmosetsmentioning

confidence: 99%

Why marmosets?

Miller

2017

Developmental Neurobiology

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The marmoset as a model for the study of primate parental behavior

Cited by 33 publications

References 126 publications

Marmosets: A Neuroscientific Model of Human Social Behavior

Marmosets: A Neuroscientific Model of Human Social Behavior

Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

Why marmosets?

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