We present a measurement of the Hubble constant H 0 from surface brightness fluctuation (SBF) distances for 63 bright, mainly early-type galaxies out to 100 Mpc observed with the Wide Field Camera 3 Infrared Channel (WFC3/IR) on the Hubble Space Telescope (HST ). The sample is drawn from several independent HST imaging programs that all used the WFC3/IR F110W (1.1 µm) bandpass. The distances reach the Hubble flow, with the majority of galaxies being in the 50-80 Mpc range. The median statistical uncertainty on individual measurements is 4%. We construct the IR SBF Hubble diagram with these distances and constrain H 0 using three different treatments of the galaxy velocities. For the SBF zero point calibration, we use both the existing tie to Cepheid variables, updated for consistency with the latest determination of the distance to the Large Magellanic Cloud from detached eclipsing binaries, and a new tie to the tip of the red giant branch (TRGB) calibrated from the maser distance to NGC 4258. These two SBF calibrations are consistent with each other and with theoretical predictions from stellar population models. From a weighted average of the Cepheid and TRGB calibrations, we derive H 0 = 73.3 ± 0.7 ± 2.4 km s −1 Mpc −1 , where the error bars reflect the statistical and systematic uncertainties. This result accords well with recent measurements of H 0 from Type Ia supernovae, time delays in multiply lensed quasars, and water masers. The systematic uncertainty could be reduced to below 2% by calibrating the SBF method with precision TRGB distances for a statistical sample of massive early-type galaxies out to the Virgo cluster measured with the James Webb Space Telescope.