The mast cells

Riley, James F.

doi:10.5962/bhl.title.6423

Cited by 253 publications

(9 citation statements)

References 139 publications

(192 reference statements)

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“…Therefore, there does not appear to be a histamine-mediated component in the decrease in MAP caused by N-type calcium channel blockade in the conscious rabbit. This ®nding is consistent with the sparse distribution of tissue mast cells surrounding the microcirculation in the rabbit compared with a dense mast cell population in rats and mice (Riley, 1959). Similarly, but in contrast to the ®ndings in the conscious rat of Bowersox et al (1992), H 1 , H 2 and H 3 receptor antagonism did not signi®cantly aect the pIC 50 for MVIIA in the rat right atrial assay.…”

Section: Conscious Rabbit Experimentssupporting

confidence: 70%

Cardiovascular and autonomic effects of ω‐conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays

Wright

Robertson

Whorlow

et al. 2000

British J Pharmacology

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1 The eects of a novel N-type voltage-operated calcium channel antagonist, o-conotoxin CVID, were compared with o-conotoxin MVIIA on sympathetic-evoked activation of right atria (RA), small mesenteric arteries (MA) and vasa deferentia (VD) isolated from the rat. Their eects were also compared on blood pressure and cardiovascular re¯exes in conscious rabbits. 2 The pIC 50 values for MVIIA and CVID, respectively, for inhibiting sympathetic-evoked responses were equivalent in RA (8.7 and 8.7) and VD (9.0 and 8.7); however, in MA the values were 8.4 and 7.7. The cardiac to vascular (RA/MA) potency ratios, antilog (plog RA ± plog MA), for MVIIA and CVID were 2 and 10. The oset rates for CVID and MVIIA were rapid, and peptide reapplication caused rapid onset of blockade, suggesting limited desensitization. 3 In the conscious rabbit, CVID and MVIIA (100 mg kg 71 i.v.) caused a similar fall in blood pressure and a tachycardia that rapidly reached maximum. Both peptides decreased the vagal-and sympathetic-mediated components of the barore¯ex, but had no eect on the vagal nasopharyngeal re¯ex. The orthostatic re¯ex to 908 tilt was blocked by MVIIA with sustained postural hypotension for 590 min after administration. In contrast, CVID caused postural hypotension at 30 min which recovered rapidly. 4 Neither CVID nor MVIIA (3 mg kg 71 i.t.) signi®cantly altered cardiovascular variables or autonomic re¯exes. 5 In conclusion, CVID appears to be relatively weak at inhibiting the re¯ex response to tilt consistent with its weaker inhibition of rat mesenteric artery constriction to perivascular nerve stimulation. This may point to subtype N-type calcium channel selectivity.

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Section: Conscious Rabbit Experimentssupporting

confidence: 70%

Cardiovascular and autonomic effects of ω‐conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays

Wright

Robertson

Whorlow

et al. 2000

British J Pharmacology

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“…The distribution of mast cells in the rat skin is not uniform; they are more numerous in the subcutaneous tissue than in the dermis and tend to concentrate perivascularly along the panniculus carnosus, as was found by Riley (1959). The changes in mast cell number following transplantation is illustrated in Figure 4.…”

Section: Histology and Mast Cellpopulation Ofgraftsmentioning

confidence: 81%

Blood Flow, Histamine Content and Histidine Decarboxylase Activity in Rat Skin Grafts and Their Modification by Cyclosporin‐A

Fan

Lewis

1982

British J Pharmacology

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An attempt has been made to monitor simultaneously the changes in blood flow, histamine content, histidine decarboxylase (HDC) activity and mast cell population in rat skin isografts and allografts. The histamine content in rat skin allografts during rejection was decreased in contrast with our earlier observation in rabbits. Although no definite correlation has been found between blood flow changes, histamine content or HDC activity, a reciprocal relationship appeared to exist between histamine content and HDC activity in the skin grafts, which might be a reflection of the immunosuppressive activity of this amine. The immunosuppressive agent, cyclosporin‐A (20 mg/kg daily) was able to prolong skin allograft survival and prevent the changes in histamine and HDC activity in allografts. Possible implications of these findings are discussed in relation to current knowledge concerning the interactions between endothelial cells, lymphocytes and mast cells/basophils in graft rejection.

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“…[1] Studies on mast cells in normal and various pathologic conditions have shown them to be complex, well-engineered, multifunctional cell playing a central role in acquired and innate immunity.…”

Section: Introductionmentioning

confidence: 99%

Role of mast cells in pathogenesis of oral lichen planus

Sharma

Sircar

Singh

et al. 2011

J Oral Maxillofac Pathol

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Recent attention has been directed toward the role of mast cells in the pathogenesis of oral lichen planus. Mast cells are responsible for trafficking inflammatory cells into the connective tissue that in turn helps in progression and maintenance of chronicity of oral lichen planus (OLP). OLP is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, and lesions contain few B-cells or plasma cells and minimal deposits of immunoglobulin or complement. Hence, OLP is ideally positioned for the study of human T-cell-mediated inflammation and autoimmunity. This study was done to evaluate the mast cell count using toluidine blue stain in OLP and compares it with oral lichenoid reaction (OLR), and to propose the possible role of mast cells in the pathogenesis of OLP and OLR. Ten cases each of OLP and OLR and five cases of normal buccal mucosa were taken from the archives of Department of Oral Pathology. The samples were stained with toluidine blue using standard toluidine blue method by Wolman 1971. An increase in mast cell count was observed in OLP and OLR in comparison to normal oral mucosa. However, no significant differences in mast cell count were noted between OLP and OLR.

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The mast cells

Cited by 253 publications

References 139 publications

Cardiovascular and autonomic effects of ω‐conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays

Cardiovascular and autonomic effects of ω‐conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays

Blood Flow, Histamine Content and Histidine Decarboxylase Activity in Rat Skin Grafts and Their Modification by Cyclosporin‐A

Role of mast cells in pathogenesis of oral lichen planus

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