The maternal brain: Neural responses to infants in mothers with and without mood disorder

Bjertrup, Anne Juul; Friis, Nellie K.; Miskowiak, Kamilla

doi:10.1016/j.neubiorev.2019.09.011

Cited by 34 publications

(22 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…In addition, mood disorders are associated with atypical neural processing of emotion in brain areas that overlap with maternal sensitivity networks (Bjertrup et al 2019 ). For example, mothers with unipolar depression display more dampened neural responses to infant signals than controls (Bjertrup et al 2019 ). It is an intriguing question whether corresponding deviations may apply to mothers with BD during interaction with their infants, given that individuals with BD have shown impairments in emotion perception and processing across different phases of the illness (Samame 2013 ; Samame et al 2012 ; Vaskinn et al 2017 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bipolar offspring and mothers: interactional challenges at infant age 3 and 12 months—a developmental pathway to enhanced risk?

Anke

Slinning

Moe

et al. 2020

Int J Bipolar Disord

View full text Add to dashboard Cite

Background: Bipolar offspring are considered a high-risk group for developing mental disorders. Developmental outcomes result from additive and interactive effects of biological vulnerability and environmental influences. Mother-infant interactions represent important early environmental influences that may modify infants' risk of mental disorders. The aim of the current prospective study was to investigate the patterns and development of motherinfant interactions in the first year of life in dyads in which the mothers have bipolar disorder (BD). Methods: Twenty-six dyads in which the mothers had BD and 28 dyads in which the mothers had no mental disorder were video-taped in a free play interaction. The Parent-Child Early Relational Assessment (PCERA) was used to assess the quality of the interactions on three domains (maternal behaviour, infant behaviour and dyadic coordination) at 3 and 12 months of infant age. First, we compared the mother-infant interaction patterns between the two groups at 12 months. Second, we investigated how the patterns developed within and between the groups from infant ages 3 to 12 months. Results: BD dyads demonstrated significantly more challenges in all three interaction domains at infant age 12 months compared to the healthy dyads. This observation was in line with the findings at infant age 3 months. Subdued expression of positive affect and mutual underinvolvement represented core challenges in maternal and infant behaviours in the BD dyads. Continuous difficulties with dyadic coordination and reciprocity were the most concerning interaction behaviours at 3 and 12 months. On the positive side, there was little expression of negative affect or tension in maternal, infant and dyadic behaviour, and some positive changes in infant behaviour from 3 to 12 months. Conclusions: The current results suggest that challenges in mother-infant interaction patterns in the first year of life may enhance the developmental risk for bipolar offspring. Clinical interventions should address both the BD mothers' needs in relation to postpartum mood deviations and mother-infant interactions. We suggest interaction interventions to promote dyadic coordination and reciprocity, such as helping mothers being more sensitive to their infant's cues and to provide attuned contingent responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bipolar offspring and mothers: interactional challenges at infant age 3 and 12 months—a developmental pathway to enhanced risk?

Anke

Slinning

Moe

et al. 2020

Int J Bipolar Disord

View full text Add to dashboard Cite

show abstract

“…Increased symptoms of maternal anxiety and depression are closely linked to the experience of stress including childhood and current adversity and parenting stress ( Goyal et al, 2010 , Guintivano et al, 2017 , Leach et al, 2017 , Thomason et al, 2014 ). Depression and anxiety disorders as well as increased symptoms during the postpartum period have been further associated with altered neural responses to infant cues ( Bjertrup et al, 2019 , Pawluski et al, 2017 ). Although there are exceptions ( Wonch et al, 2015 ), depressed mothers exhibit dampened PFC activity in response to cry sounds from their own infant ( Laurent and Ablow, 2011 ) and reduced orbitofrontal cortex and precuneus in response to infant images ( Lenzi et al, 2016 ), and mothers with higher depressive symptoms also show reduced connectivity between the amygdala and nucleus accumbens in response to infant cry sounds ( Ho and Swain, 2017 ).…”

Section: Neurobiological Mechanisms By Which Stress Exposure Impacts mentioning

confidence: 99%

How stress can influence brain adaptations to motherhood

Kim

2021

Frontiers in Neuroendocrinology

View full text Add to dashboard Cite

Highlights The brain plasticity supports human mothers’ transition to parenthood. Stress can negatively influence maternal brain responses to infant cues. The maternal brain is affected by stress in childhood and the perinatal period. Altered responses to infant cues are associated with suboptimal parenting behaviors. Implications for intervention and directions for future work are discussed.

show abstract

“…Neuroscience researchers are bringing efforts to identify the unique neurobiological and pharmacokinetic profiles of PPD, and numerous authors have reviewed the neuroimaging literature on the topic (113,(116)(117)(118). In humans, functional MR Imaging is the current preferred choice of study of PPD.…”

Section: Do These Structural Changes Have An Implication In Postpartum Mental Health?mentioning

confidence: 99%

Characterizing the Brain Structural Adaptations Across the Motherhood Transition

Martínez‐García

Paternina-Die

Desco

et al. 2021

Front. Glob. Womens Health

View full text Add to dashboard Cite

Women that become mothers face notable physiological adaptations during this life-period. Neuroimaging studies of the last decade have provided grounded evidence that women's brains structurally change across the transition into motherhood. The characterization of this brain remodeling is currently in its early years of research. The current article reviews this scientific field by focusing on our longitudinal (pre-to-post pregnancy) Magnetic Resonance Imaging (MRI) studies in first-time parents and other longitudinal and cross-sectional studies of parents. We present the questions that are currently being answered by the parental brain literature and point out those that have not yet been explored. We also highlight potential confounding variables that need to be considered when analyzing and interpreting brain changes observed during motherhood.

show abstract

The maternal brain: Neural responses to infants in mothers with and without mood disorder

Cited by 34 publications

References 73 publications

Bipolar offspring and mothers: interactional challenges at infant age 3 and 12 months—a developmental pathway to enhanced risk?

Bipolar offspring and mothers: interactional challenges at infant age 3 and 12 months—a developmental pathway to enhanced risk?

How stress can influence brain adaptations to motherhood

Characterizing the Brain Structural Adaptations Across the Motherhood Transition

Contact Info

Product

Resources

About