The Mathematics of Drug Delivery

Hinow, Peter; Radunskaya, Ami

doi:10.1007/978-1-4939-1793-8_5

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Modeling of the release patterns for drug delivery systems is very important to understand the mechanism of the release. The release profiles of the drugs depend upon numerous factors like the drug–carrier interaction, nature of the DDS, microenvironment effecting the system, porosity of the system, etc . The synthesized AQ have a drug and a matrix form and are considered as “monolithic systems”.…”

Section: Resultsmentioning

confidence: 99%

“…The release profiles of the drugs depend upon numerous factors like the drug−carrier interaction, nature of the DDS, microenvironment effecting the system, porosity of the system, etc. 69 The synthesized AQ have a drug and a matrix form and are considered as "monolithic systems". These monolithic systems are further classified into "monolithic dispersions" and "monolithic solutions".…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

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Synthesis, Detailed Characterization, and Dual Drug Delivery Application of BSA Loaded Aquasomes

Damera

Kaja

Janardhanam

et al. 2019

ACS Appl. Bio Mater.

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Aquasomes (AQ) are self-assembled nanostructures, made up of a spherical hydroxyapatite core and a carbohydrate layer on top, for delivering bioactive molecules like proteins, peptides, etc., which are adsorbed on the carbohydrate layer. This is the first report of its kind demonstrating AQ as an efficient dual drug delivery system, capable of releasing bioactive molecule and a hydrophobic drug together. The synthesized AQ before and after adsorption of the bioactive molecule are characterized using dynamic light scattering, scanning electron microscopy, X-ray diffraction, small-angle X-ray scattering, Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and Raman spectroscopy. BSA (bovine serum albumin) protein is used as the model bioactive molecule for the in vitro dual release studies along with representative hydrophobic drugs Coumarin 153 (C153), Warfarin (WAR), and Ibuprofen (IBU). The release behaviors of the hydrophobic drugs are explained by studying their binding interactions with BSA. The binding interactions of the drugs with BSA are analyzed by carrying out fluorescence quenching experiment of BSA, site marking competition experiment, anisotropy, and E T (30) studies. Further, in vitro biocompatibility studies are performed for dually loaded AQ by using hemolysis assay. The hemolysis assay do not show any lysing of the red blood cells, suggesting the formulations to be clinically capable for administration.

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Section: Resultsmentioning

confidence: 99%

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Synthesis, Detailed Characterization, and Dual Drug Delivery Application of BSA Loaded Aquasomes

Damera

Kaja

Janardhanam

et al. 2019

ACS Appl. Bio Mater.

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Signaled drug delivery and transport across the blood–brain barrier

Hinow

Radunskaya

Mackay

et al. 2015

Journal of Liposome Research

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We use a mathematical model to describe the delivery of a drug to a specific region of the brain. The drug is carried by liposomes that can release their cargo by application of focused ultrasound (US). Thereupon, the drug is absorbed through the endothelial cells that line the brain capillaries and form the physiologically important blood-brain barrier (BBB). We present a compartmental model of a capillary that is able to capture the complex binding and transport processes the drug undergoes in the blood plasma and at the BBB. We apply this model to the delivery of levodopa (L-dopa, used to treat Parkinson's disease) and doxorubicin (an anticancer agent). The goal is to optimize the delivery of drug while at the same time minimizing possible side effects of the US.

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The Mathematics of Drug Delivery

Cited by 2 publications

References 29 publications

Synthesis, Detailed Characterization, and Dual Drug Delivery Application of BSA Loaded Aquasomes

Synthesis, Detailed Characterization, and Dual Drug Delivery Application of BSA Loaded Aquasomes

Signaled drug delivery and transport across the blood–brain barrier

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