The Meaning of Translational Research and Why It Matters

Woolf, Steven H.

doi:10.1001/jama.2007.26

Cited by 1,505 publications

(1,200 citation statements)

References 17 publications

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“…In addition, the DPP study screened a sample of highly motivated individuals who received incentives to stay in the trial. In contrast, real world populations and the settings that serve [22]. This study illustrated a five-step framework to translate the DPP to be delivered to diverse lowincome postpartum women enrolled in the WIC program, a population vulnerable to postpartum weight retention and also postpartum weight gain [2].…”

Section: Discussionmentioning

confidence: 99%

Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Rosal¹,

Lemon²,

Nguyen³

et al. 2011

Behav. Med. Pract. Policy Res.

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The Women Infants and Children (WIC) program is a promising venue in which to implement weight loss interventions for low-income postpartum women. The goals of this study were to describe formative steps to translate the DPP lifestyle intervention to be delivered to diverse low-income postpartum women who are served by the WIC program, and to present the results of a pilot trial of the intervention. The steps of intervention translation involved were the following: (1) building partnerships, (2) understanding the target setting, (3) understanding the target population, (4) re-designing the intervention, and (5) refining the intervention. The pilot trial was a single group pre/post test comparison among 27 overweight/obese postpartum WIC clients. The intervention resulted in an average weight loss of 4.6lb at a 4-month follow-up (p=0.004). A dose-response association between intervention attendance and weight loss was observed. This translation of the DPP for diverse low-income postpartum women has potential for widespread implementation. KEYWORDS Weight loss, Health disparities, Intervention, Translational researchThe postpartum period is a critical time for targeting weight loss, as on average, women retain approximately 3 kg per pregnancy over the life course [1]. Low SES and minority women are at greatest risk of postpartum weight retention, and these populations also experience significant weight gain after the first few postpartum weeks [2]. The Women Infants and Children (WIC) program is a promising setting in which to implement evidence-based weight loss interventions for low SES women. WIC is a federaland state-funded program with a mission to promote health of low-income women, infants, and children up to age 5 who are at nutritional risk. WIC serves approximately 18 million individuals a year via 9,000 clinics across the country. The program does not systematically provide weight loss services per se, but addressing weight loss among its participants is within the mission of WIC.Only a few interventions have aimed to promote postpartum weight loss among WIC clients and have had minimal or no success [2][3][4]. These interventions have not used or translated existing evidence-based programs or strategies [5,6] (i.e., limited focus on creating an energy deficit; nonsystematic use of self-monitoring, goal-setting and problem-solving, and limited hands-on opportunities and support to develop healthy cooking skills and physical activity behaviors). In addition, studies reported poor attendance and high attrition rates.Despite the promise of efficacious weight loss interventions such as the Diabetes Prevention Program (DPP) Lifestyle Intervention [5,7], to date only a few studies have demonstrated a positive effect of using the DPP intervention in real world settings and populations [8]. There are sizeable barriers to widespread implementation and dissemination of efficacious weight loss interventions like the DPP to real world settings and populations, such as WIC clinics and the low SES postpartum ...

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Section: Discussionmentioning

confidence: 99%

Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Rosal¹,

Lemon²,

Nguyen³

et al. 2011

Behav. Med. Pract. Policy Res.

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“…This field, generally referred to as translational research (Woolf 2008), has become a priority among policy makers, practitioners, researchers, and educators. While much attention has been focused on the importance of translational research, particularly in the area of children's behavioral and mental health (O'Connell et al 2009), there has been relatively limited work aimed at understanding and describing the role that partnerships play in the translation process.…”

mentioning

confidence: 99%

Building a Science of Partnership-Focused Research: Forging and Sustaining Partnerships to Support Child Mental Health Prevention and Services Research

Bradshaw

Haynes

2012

Adm Policy Ment Health

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“…The RE-AIM framework is rooted in translational science [7,8] because it encompasses the implementation activities across the domains of research, practice, application, and policy [9][10][11][12][13]. This is of significance to behavioral medicine as dissemination and adoption of evidence-based research takes on an average of 17 years from concept to translation into population-based interventions for the 14 % of the evidence that translates [14,15].…”

Section: Introductionmentioning

confidence: 99%

Network analysis of RE-AIM framework: chronology of the field and the connectivity of its contributors

Shoup

Gaglio

Varda

et al. 2014

Behav. Med. Pract. Policy Res.

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The reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework has been widely used for translational research. We used social network analysis (SNA) to explore how innovative research frameworks, such as RE-AIM, have diffused over time in academic literature. A structured literature review was conducted on RE-AIM between 1999 and 2012. SNA indices of degree score, betweenness, centrality, and authorship ties were used to examine use of RE-AIM. Use of RE-AIM has grown since its inception and spread from a few research centers to use internationally. Investigation of co-authorship revealed many have published on RE-AIM, but a much smaller core of RE-AIM researchers have published together two or more times. SNA revealed how the RE-AIM framework has been used over time and identified areas to further expand use of the framework. SNA can be useful to understand how research frameworks diffuse over time.

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The Meaning of Translational Research and Why It Matters

Cited by 1,505 publications

References 17 publications

Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Building a Science of Partnership-Focused Research: Forging and Sustaining Partnerships to Support Child Mental Health Prevention and Services Research

Network analysis of RE-AIM framework: chronology of the field and the connectivity of its contributors

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