The measurement and modelling of the mechanical properties of human skin in vivo—I. The measurement

Manschot, J.F.M.; Brakkee, A. J. M.

doi:10.1016/0021-9290(86)90124-7

Cited by 107 publications

(51 citation statements)

References 8 publications

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“…The density of fibroblasts in the dermis was reported to be 2.1 × 10 3 to 4.1 × 10 3 cells/mm 3 [20]. The interstitium (dermis in our case) is considered to be under tension generated by the tractional force of fibroblasts [8], which was quantified to be 1-7 × 10 5 N/m 2 [25,26]. The collagen concentration was determined as ~20% on the wet weigh basis [16].…”

Section: Resultsmentioning

confidence: 99%

“…Generally, the studies have been quite limited, which directly measured in vivo tensile strength of living tissues in resting conditions or of the tissues that actively undergoing morphogenesis. However, there were a series of study, which described the mechanical properties of human skin in vivo [25,26]. This kind of study could provide practically valuable information to us when we design a 3D collagen culture that more appropriately reflects in vivo situation of tensile strength.…”

Section: Internal Tension/compression In and On Fibroblasts And Ecmmentioning

confidence: 99%

See 1 more Smart Citation

Cell culture in three-dimensional lattices of hydrated collagen fibrils – its progress and perspectives

Saito¹,

Tanaka²,

Nakata³

et al. 2015

Int. J. DNE

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Cell culture methodology has been utilized as a powerful tool to characterize cells with a presupposition that the cells in culture faithfully reproduce their in vivo phenotypes. However, it is generally recognized that the cells cultured currently by the most commonly utilized two-dimensional (2D) monolayer technology exhibit different phenotypes from those in living tissues. Cultivation of cells in three-dimensional (3D) lattices of collagen fibrils (collagen gel culture) has been thought to overcome the shortages of 2D cell culture such that the cells behave as in vivo by interacting with not only nearby other cells but also by surrounding extracellular matrices. A remarkable outcome of studies on collagen gel culture was a demonstration of contractile nature of the cells. One of the not-fully appreciated issues about the 3D cell culture is the effect of fluid flow through the collagen gels on cells' phenotypes. In this review, we make a short overview of historical and current studies of the collagen gel culture from a viewpoint of 'how we can more correctly extract the cell-related phenomena in living tissues/organs by in vitro culture technology, placing an emphasis on the importance of stimuli caused by flow of cell culture medium.'

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Section: Resultsmentioning

confidence: 99%

Section: Internal Tension/compression In and On Fibroblasts And Ecmmentioning

confidence: 99%

Cell culture in three-dimensional lattices of hydrated collagen fibrils – its progress and perspectives

Saito¹,

Tanaka²,

Nakata³

et al. 2015

Int. J. DNE

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show abstract

“…Static methods of skin elas ticity examination are based on measurement of linear displacement or deformation induced by mechanical stress. Most widely used methods are based on twisting, one axis, or two axis expansion, cross deformation (vac uum cutometry and indentation) [13].…”

Section: Introductionmentioning

confidence: 99%

Hardware–Software System for Assessing Elastic–Dissipative Properties of Skin Integument

Jatsun¹,

Кореневский²,

Jatsun³

2009

Biomed Eng

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“…This method has distinct advantages over the conventional approaches [1,2,3,4,5]. Firstly, both non-linear characteristics and subcutaneous structure are incorporated at a time.…”

Section: Iterative Fe Analysismentioning

confidence: 99%

“…One intuitive method is to indent the surface of the tissue [1,2]. Material property is then obtained from the relation between the indentation depth and the reaction force.…”

Section: Introductionmentioning

confidence: 99%

Material Properties Estimation of Layered Soft Tissue Based on MR Observation and Iterative FE Simulation

Tada

Nagai

Maéno

2005

Lecture Notes in Computer Science

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Abstract. In order to calculate deformation of soft tissue under arbitrary loading conditions, we have to take both non-linear material characteristics and subcutaneous structures into considerations. The estimation method of material properties presented in this paper accounts for these issues. It employs a compression test inside MRI in order to visualize deformation of hypodermic layered structure of living tissue, and an FE model of the compressed tissue in which non-linear material model is assigned. The FE analysis is iterated with updated material constant until the difference between the displacement field observed from MR images and calculated by FEM is minimized. The presented method has been applied to a 3-layered silicon rubber phantom. The results show the excellent performance of our method. The accuracy of the estimation is better than 15 %, and the reproducibility of the deformation is better than 0.4 mm even for an FE analysis with different boundary condition.

show abstract

The measurement and modelling of the mechanical properties of human skin in vivo—I. The measurement

Cited by 107 publications

References 8 publications

Cell culture in three-dimensional lattices of hydrated collagen fibrils – its progress and perspectives

Cell culture in three-dimensional lattices of hydrated collagen fibrils – its progress and perspectives

Hardware–Software System for Assessing Elastic–Dissipative Properties of Skin Integument

Material Properties Estimation of Layered Soft Tissue Based on MR Observation and Iterative FE Simulation

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