The measurement of spleen perfusion in man: A non-invasive method using the ratio between rubidium-81 and its decay product krypton-81m

Jones, T.S.; Pettit, John E.; Rhodes, C. G.; Waters, S.L.

doi:10.1007/bf00252569

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…They go on to show a proof-of-concept measurement of perfusion in a mock system where 81 Rb is trapped on cation exchange resin, and 81m Kr is washed away by controlled flow of deionized water over the resin. Several other examples of the use of 81 Rb/ 81m Kr as an in vivo generator appear in the literature [23–25]. …”

Section: In Vivo Generators For Diagnosticsmentioning

confidence: 99%

In Vivo Radionuclide Generators for Diagnostics and Therapy

Edem

Fonslet

Kjær

et al. 2016

Bioinorganic Chemistry and Applications

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In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived α-emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

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Section: In Vivo Generators For Diagnosticsmentioning

confidence: 99%

In Vivo Radionuclide Generators for Diagnostics and Therapy

Edem

Fonslet

Kjær

et al. 2016

Bioinorganic Chemistry and Applications

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“…8 1 Rb einerseits und 81m Kr andererseits: im Gegensatz zur reduzierten 2()1 T1-bzw. 81 Rb-Belegung war die 8 suffering from unstable angina; of these, 4 complained of progressive angina (frequent anginal attacks during the last 6 weeks) and 5 patients had angina at rest. Of the 9 patients with unstable angina, 4 patients gave a history of earlier myocardial infarction.…”

Section: Zusammenfassungmentioning

confidence: 99%

“…In 1971, Jones and Matthews (7) proposed a non-invasive method for blood flow assessment using the ratio of 81 Rb (a positron-emitting radionuclide with a 4.6-h half-life) to its diffusible decay product 8 l m Kr (an inert gas with a half-life of 13 sec and a single 190 keV y-ray ): with 81 Rb bound within an organ and continuously generating inert 81m Kr, blood flow at equilibrium can be assessed by measuring the regional count rate ratio between 81m Kr and its parent 81 Rb (6,8,11,13).…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Detection of Reduced Regional Myocardial Perfusion at Rest in Patients with Unstable Angina Pectoris: Increased Regional 81mKr Deposition following Intravenous Injection of 81 Rb

Zimmermann

Tillmanns²,

Bubeck³

et al. 1991

Nuklearmedizin

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The present study was to investigate whether combined imaging of 81 Rb and 81mKr distributions after i.v. injection of 81 Rb at rest might improve the differentiation between ischemic and irreversibly damaged myocardium as compared to 201TI scintigraphy at rest. In 21 patients who had undergone diagnostic cardiac catheterization for evaluation of chest pain, 148 MBq ultrapure 81 Rb were injected i.v. at rest immediately following 201TI scintigraphy at rest. Of 14 patients with earlier myocardial infarction, 10 patients revealed decreased regional tracer uptake of 81 Rb and/or 81mKr, compared to 12 patients with regional 201TI uptake abnormalities. In 3 patients with unstable angina pectoris, however, an evident mismatch between either the regional 201TI or 81 Rb distributions and the distribution of 81mKr was observed: in contrast to the reduced uptake of 201TI and/or 81 Rb, 81mKr activity was increased in 3 myocardial segments with normal left ventricular performance but supplied by coronary arteries with high-grade stenoses. In patients with contraindications to exercise tests (e.g. unstable angina) 81Rb/81mKr rest scintigraphy may therefore assist the differentiation between malperfused but potentially viable and irreversibly damaged myocardium.

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