The mechanical integrity of healed diaphyseal bone defects grafted with calcium hydroxyapatite/calciu triphosphate ceramic in a new animal model

Black, R.John; Zardiackas, Lyle D.; Teasdall, Robert D.; Hughes, James L.

doi:10.1016/0267-6605(90)90062-z

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Besides, mechanical testing is applied to determine the strength of the regenerated bone defect. A review of the literature shows that mechanical tests, such as torsional, [8][9][10][11][12][13][14][15] three points bending, 16 and tensile strength 17 measurements, are used to evaluate the force of the healed bone. All these mechanical methods are associated with advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Torque Test Measurement in Segmental Bone Defects Using Porous Calcium Phosphate Cement Implants

Kroese-Deutman

Wolke

Spauwen

et al. 2010

Tissue Engineering Part C: Methods

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This study was performed to assess the bone healing supporting characteristics of porous calcium phosphate (Ca-P) cement when implanted in a rabbit segmental defect model as well as to determine the reliability of torque testing as a method to verify bone healing. The middiaphyseal radius was chosen as the area to create bilaterally increasing defect sizes (5, 10, and 15 mm), which were either filled with porous Ca-P cement or left open as a control. After 12 weeks of implantation, torque test measurements as well as histological and radiographic evaluation were performed. In two of the open 15 mm control defects, bone bridging was visible at the radiographic and histological evaluation. Bone was observed to be present in all porous Ca-P cement implants (5, 10, and 15 mm defects) after 12 weeks. No significant differences in torque measurements were observed between the 5 and 10 mm filled and open control defects using a t-test. In addition, the mechanical strength of all operated specimens was similar compared with nonoperated bone samples. The torsion data for the 15 mm open defect appeared to be lower compared with the filled 15 mm defect, but no significant difference could be proven. Within the limitation of the study design, porous Ca-P cement implants demonstrated osteoconductive properties and confirmed to be a suitable scaffold material in a weight-bearing situation. Further, the used torque testing method was found to be unreliable for testing the mechanical properties of the healed bone defect.

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Section: Introductionmentioning

confidence: 99%

Torque Test Measurement in Segmental Bone Defects Using Porous Calcium Phosphate Cement Implants

Kroese-Deutman

Wolke

Spauwen

et al. 2010

Tissue Engineering Part C: Methods

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“…The differences seen in the White et al fracture-type analysis correlated with the fact that three of the dogs in group I1 had larger calluses reminiscent of those seen in the original study where the graft was found as part of a large callus adjacent to the original defect. 6 Examination of the energy to fracture data showed a trend toward higher energy values for all unoperated bones but as previously stated, data analysis did not show statistical significance. This trend of higher energy to fracture values for the unoperated, contralateral femora along with evaluation of the fracture mode as described by White et al indicates that to approach complete remodeling, greater time would be required.…”

Section: Discussionmentioning

confidence: 62%

Torsional properties of healed canine diaphyseal defects grafted with a fibrillar collagen and hydroxyapatite/tricalcium phosphate composite

Zardiackas

Teasdall

Black

et al. 1994

J of Applied Biomaterials

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The need for alternatives to autogenous bone grafts is widely recognized. This study compared the torsional strength of canine femora 1 year after grafting with one of three forms of a collagen/hydroxyapatite/tricalcium phosphate bone grafting material (COLLAGRAFTTM), autogenous bone, or no graft. The groups were compared to each other and to the unoperated contralateral femora. Results of torsional testing were evaluated for torsional strength, torsional displacement, total energy to fracture and White fracture mode. Data analysis showed lower torsional strength of the operated vs. unoperated femora with the exception of morsellized COLLAGRAFTTM material, which had higher strength. However, the only difference in the operated groups was that the morsellized COLLAGRAFTTM had greater strength than several groups including the autogenous bone group. There was no difference found in angular displacement between any of the groups. However, there was a difference in the energy to fracture in both strip forms of the COLLAGRAFTTM. The final conclusion is that in this model, grafting with COLLAGRAFTTM provided torsional properties at one year postoperatively at least equivalent to autogenous bone.

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“…Numerous researches have been dedicated to the development and evaluation of a synthetic substitute because of the significant problems associated with the limitation of suitable autogenous bone graft. Several materials have been tried and found to be inappropriate but the most promising materials to date are those based on calcium Hydroxyapatite (HA) [1]. Various HA synthesis techniques have been developed such as precipitation method [2], hydrothermal synthesis [3], solid state reaction [4] and sol-gel procedure [5].…”

Section: Introductionmentioning

confidence: 99%

A process for the development of strontium hydroxyapatite

Zahra¹,

Fayyaz²,

Iqbal³

et al. 2014

IOP Conf. Ser.: Mater. Sci. Eng.

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The mechanical integrity of healed diaphyseal bone defects grafted with calcium hydroxyapatite/calciu triphosphate ceramic in a new animal model

Cited by 8 publications

References 8 publications

Torque Test Measurement in Segmental Bone Defects Using Porous Calcium Phosphate Cement Implants

Torque Test Measurement in Segmental Bone Defects Using Porous Calcium Phosphate Cement Implants

Torsional properties of healed canine diaphyseal defects grafted with a fibrillar collagen and hydroxyapatite/tricalcium phosphate composite

A process for the development of strontium hydroxyapatite

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