The mechanical loading and muscle activation of four common exercises used in osteoporosis prevention for early postmenopausal women

Montgomery, Gallin; Abt, Grant; Dobson, Catherine; Smith, Tina; Evans, W. T.; Ditroilo, Massimiliano

doi:10.1016/j.jelekin.2018.12.004

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…Osteoporosis (OP) is a progressive bone disease characterized by low bone mass and degeneration of bone microstructure, which leads to increased bone brittleness and an increased risk of fracture [ 76 ]. Many studies have shown that proper exercise or mechanical stimulation can prevent or treat OP [ 97 , 98 , 99 ].…”

Section: Piezo Channels and Bone Diseasementioning

confidence: 99%

Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

Liu

et al. 2021

IJMS

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Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels’ functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels’ function in bone by highlighting Piezo1′s role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized.

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Section: Piezo Channels and Bone Diseasementioning

confidence: 99%

Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

Liu

et al. 2021

IJMS

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“…When the Soviet astronauts flew in space for 75 to 184 days, the bone mineral density (BMD) of the calcaneus decreased 0.9–19.8%, and the spine BMD decreased about 0.3–10.8% for the astronauts who stayed at the Salute Space Station for 5 to 7 months 4 . At present, several preventative and therapeutic strategies have shown good efficacy for bone loss induced by spaceflight, such as physical exercise, mechanical stimulation and drug therapy 5 , 6 , but still have certain limitations and significant deficiencies. Among them, drug treatments such as bisphosphonates have significant protective effects on bone loss induced by microgravity, but there were the inevitable side effects, such as osteonecrosis of the jaw, headache and nausea 7 – 9 .…”

Section: Introductionmentioning

confidence: 99%

Calycosin prevents bone loss induced by hindlimb unloading

et al. 2022

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Bone loss induced by microgravity exposure seriously endangers the astronauts’ health, but its countermeasures still have certain limitations. The study aims to find potential protective drugs for the prevention of the microgravity-induced bone loss. Here, we utilized the network pharmacology approach to discover a natural compound calycosin by constructing the compound-target interaction network and analyzing the topological characteristics of the network. Furthermore, the hind limb unloading (HLU) rats’ model was conducted to investigate the potential effects of calycosin in the prevention of bone loss induced by microgravity. The results indicated that calycosin treatment group significantly increased the bone mineral density (BMD), ameliorated the microstructure of femoral trabecular bone, the thickness of cortical bone and the biomechanical properties of the bone in rats, compared that in the HLU group. The analysis of bone turnover markers in serum showed that both the bone formation markers and bone resorption markers decreased after calycosin treatment. Moreover, we found that bone remodeling-related cytokines in serum including IFN-γ, IL-6, IL-8, IL-12, IL-4, IL-10 and TNF-α were partly recovered after calycosin treatment compared with HLU group. In conclusion, calycosin partly recovered hind limb unloading-induced bone loss through the regulation of bone remodeling. These results provided the evidence that calycosin might play an important role in maintaining bone mass in HLU rats, indicating its promising application in the treatment of bone loss induced by microgravity.

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“…6 Notably, high-impact exercise can reduce postmenopausal bone loss. 7 In addition, dyslipidemia is one of the lifestyle-related diseases that often occur in women after menopause. 8 It is known that estrogen deficiency associated with menopause affects lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, male hormones are the only source of female hormones after menopause. Therefore, correlation (7) holds: male hormone ! female hormone…”

Section: Introducing Deviationmentioning

confidence: 99%

Chemical equilibrium model comprising calcaneus bone mineral density, low-density lipoprotein cholesterol, and physical work capacity in premenopausal women

Mitsuhashi

Imagawa²,

Kojima³

et al. 2022

F1000Res

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Background: During menopause, bone density decreases, and low-density lipoprotein cholesterol (LDL-C) rapidly increases; a decrease in the estrogen level is a common factor in these phenomena. Methods: In this study, we focused on the fact that menopause is a spontaneous process, and aimed to derive the conditions that mitigate the decline in the osteo sono-assessment index (OSI), an index of bone mineral density (BMD), using a chemical equilibrium model. We attempted to establish the relationship between variables related to female hormone secretion (OSI, LDL-C) and a variable related to work capacity (physical work capacity [PWC] at 75% of maximal heart rate) by analogy, using the fact that Gibbs free energy, a thermodynamic variable related to spontaneous change, is related by three variables. Results: Consequently, if linearity is established between PWC and OSI when LDL-C is used as the standard, then the analogy of chemical equilibrium can be established between the deviation values of these three variables, with equilibrium constant K. Finally, the theoretically determined equilibrium model with constant K was applied to data obtained from the Sports Program Service (SPS) of the Yokohama Sports Medical Center. Conclusions: The present study suggests that the decrease in bone density could be alleviated by promoting an increase in LDL-C or by mitigating the decrease in PWC. In discussing personal health, mitigating bone density loss and maintaining a high work capacity are important components, which should also take into account the appropriate levels of LDL-C.

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The mechanical loading and muscle activation of four common exercises used in osteoporosis prevention for early postmenopausal women

Cited by 8 publications

References 44 publications

Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

Calycosin prevents bone loss induced by hindlimb unloading

Chemical equilibrium model comprising calcaneus bone mineral density, low-density lipoprotein cholesterol, and physical work capacity in premenopausal women

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