The mechanical properties of composites manufactured from tendon fibres and pearl glue (animal glue)

Hepworth, David; Smith, J. David

doi:10.1016/s1359-835x(02)00025-8

Cited by 14 publications

(13 citation statements)

References 8 publications

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“…This result is in agreement with previous observations, where it was noted that very little free interfibrillar space occurs in fibers formed in vitro 56. Furthermore, the interfibrillar space has been reported to be filled when polymers were utilized for the production of composite fibers57 and elastin‐based materials 58. Detailed TEM investigation revealed that only the acid‐soluble treatments led to, invariably and reproducibly, the quarter‐staggered axial arrangement characteristic of fibrous collagen, while the pepsin‐soluble treatments appeared to give the cross‐striation pattern only when thick aggregates were formed.…”

Section: Discussionsupporting

confidence: 93%

Factors influencing the properties of reconstituted collagen fibers prior to self‐assembly: Animal species and collagen extraction method

Zeugolis

Paul

Attenburrow

2007

J Biomedical Materials Res

130

109

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This research work allows a direct comparison between collagen solutions of equal concentration derived from the two widely used collagen sources: bovine Achilles tendon (BAT) and rat tail tendon (RTT), and extraction methods: acid (AS) and pepsin (PS) solubilization on the properties of extruded collagen fibers. Scanning electron microscopy revealed that the substructure of the collagen fibers was the same independent of the treatment. Transmission electron microscopy revealed that the AS collagen-derived fibers were comprised of thick quarter-staggered fibrils, while the coexistence of thin nonbanded and thick banded fibrils was apparent for the PS collagen-derived fibers. The BAT-derived fibers demonstrated higher denaturation temperature than the RTT-derived ones (p < 0.05). The extraction method had no influence on the thermal characteristics of the fibers produced (p > 0.05). ASBAT collagen was of higher viscosity than both ASRTT and PSBAT (p < 0.002), and therefore larger diameter fibers were obtained (p < 0.001). An inversely proportional relationship between dry-fiber diameter and stress at break was observed within the treatments. The PS yielded 10 times more soluble collagen from BAT and the derived fibers were of similar tensile strength, stiffness, and elongation (p > 0.05) as those derived from the AS collagen. No significant difference was observed for the stress at break for the ASBAT and the ASRTT, while significant difference was observed for the elongation and modulus values (p < 0.005). Overall, reconstituted collagen fibers were produced with properties similar to native or synthetic fibers to suit a wide range of tissue engineering applications.

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Section: Discussionsupporting

confidence: 93%

Factors influencing the properties of reconstituted collagen fibers prior to self‐assembly: Animal species and collagen extraction method

Zeugolis

Paul

Attenburrow

2007

J Biomedical Materials Res

130

109

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“…For example, microbial transglutaminase has no influence on the surface of the collagen matrix,89 while surface irregularities have been reported for UV‐irradiated rat tail tendon fibers 90. The interfiber space, however, was found consistently filled, which is in agreement with previous observations for collagen fibers,91 composite fibers92 and elastin based materials 93. The fracture modes identified are in accord with previous publications,30, 94–96 where their relative occurrence was attributed to the handling of the fibers while in the wet state; to the strain rate; or even to flaws within the fiber structure.…”

Section: Discussionsupporting

confidence: 89%

One‐step synthesis of triarm block copolymers via simultaneous reversible‐addition fragmentation chain transfer and ring‐opening polymerization

Öztürk

Göktaş

Hazer

2010

J of Applied Polymer Sci

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One‐step synthesis of star copolymers by reversible addition–fragmentation chain transfer (RAFT) and ring‐opening polymerization (ROP) by using a novel dual initiator is reported. Triarm block copolymers comprising one polystyrene (or polyacrylamide) arm and two poly(β‐butyrolactone) arms were synthesized in one‐step by simultaneous RAFT polymerization of styrene (St) (or acrylamide, designated as AAm) and ROP of β‐butyrolactone (BL) in the presence of a novel trifunctional initiator, 1,2‐propanediol ethyl xanthogenate (RAFT‐ROP agent). This dual initiator was obtained through the reaction of 3‐chloro‐1,2‐propanediol with the potassium salt of ethyl xanthogenate. The principal parameters such as monomer concentration, initiator concentration, and polymerization time that affect the one‐step polymerization reaction were evaluated. The characterization of the products was achieved using Fourier‐transform infrared spectroscopy (FTIR), 1H‐nuclear magnetic resonance (1H‐NMR), 13C‐nuclear magnetic resonance (13C‐NMR), Gas chromatography–mass spectrometry (GC–MS), gel‐permeation chromatography (GPC), thermogravimetric analysis (TGA), and fractional precipitation (γ) techniques. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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“…Although it was not investigated during the current study, this yielding mechanism would imply some form of flow occurring within the fibrous structure, possibly interfibrillar slippage. In vivo, this mechanism is very important in the tensile deformation of connective tissues such as tendon, skin and pericardium [54][55][56]. Similar stress-strain curves have also been reported previously for collagenbased biomaterials [57][58][59][60][61][62][63][64] and nano-fibrous meshes [65][66][67].…”

Section: Discussionsupporting

confidence: 75%

Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions

English

Azeem

Gaspar

et al. 2011

J Mater Sci: Mater Med

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Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, osteoblasts and corneal fibroblasts to the topographies created through electro-spinning and solvent casting. We also evaluated the influence of topography on mechanical properties. At day 14, human osteoblasts seeded on aligned orientated electro-spun mats exhibited the lowest metabolic activity (P \ 0.001). At day 5 and at day 7, no significant difference was observed in metabolic activity of human corneal fibroblasts and bovine tenocytes respectively seeded on different scaffold conformations (P [ 0.05). Osteoblasts and corneal fibroblasts aligned parallel to the direction of the aligned orientated electro-spun mats, whilst tenocytes aligned perpendicular to the aligned orientated electro-spun mats. Mechanical evaluation demonstrated that aligned orientated electro-spun fibres exhibited significant higher stress at break values than their random aligned counterparts (P \ 0.006) and random orientated electro-spun fibres exhibited significant higher strain at break values than the aligned orientated scaffolds (P \ 0.006). While maintaining fibre structure, we also developed a co-deposition method of spraying and electro-spinning, which enables the incorporation of microspheres within the three-dimensional structure of the scaffold.

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The mechanical properties of composites manufactured from tendon fibres and pearl glue (animal glue)

Cited by 14 publications

References 8 publications

Factors influencing the properties of reconstituted collagen fibers prior to self‐assembly: Animal species and collagen extraction method

Factors influencing the properties of reconstituted collagen fibers prior to self‐assembly: Animal species and collagen extraction method

One‐step synthesis of triarm block copolymers via simultaneous reversible‐addition fragmentation chain transfer and ring‐opening polymerization

Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions

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