The Mechanism Adapting the Oxygen Capacity of the Blood to the Requirements of the Tissues

Dallwig, H. C.; Kolls, A. C.; Loevenhart, A. S.

doi:10.1152/ajplegacy.1915.39.1.77

Cited by 33 publications

(10 citation statements)

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“…I f then we may regard the marrow as an organ, we have an instance of the hypertrophy of* an organ in man brought about by a climatic change, namely, exposure to low barometric pressure. In animals it has been observed by Zuntz and his colleagues (10) on Monte Rosa, and by Dali wig, Rolls and Loevenhart in chamber experiments (32). *…”

Section: Anglosaxons Atmentioning

confidence: 79%

VIII.—Observations upon the effect of high altitude on the physiological processes of the human body, carried out in the Peruvian Andes, chiefly at Carro de Pasco. - Report to the Peru High-Altitude Committee

Barcroft

Binger

Bock

et al. 1923

Phil. Trans. R. Soc. Lond. B

166

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What is reported in the following pages is an example of work achieved in a relatively short time by the co-operation of a sufficient number of institutions and individuals. The venue of this research was in the Andes, and the work was carried out in the winter 1921-1922, yet its organisation only commenced definitely in the early summer of 1921, when a group of British and American physiologists secured the support of the various universities or other institutions to which they were attached. This support was given in the most ungrudging way. It included the liberation from immediate duty of the members of the party, often at considerable inconvenience to those who remained at home, the loan of apparatus, the contribution of substantial funds, and a great body of goodwill, which was perpetually translating itself into increased efficiency of the work actually accomplished. The following collaborated in one or more of the ways indicated above:— The Department of Physical Chemistry of Harvard University. The Proctor Fund of Harvard University. The Elizabeth Thompson Fund. The Rockefeller Institute of Medical Research, New York City. Columbia University.—From a fund, to which contributions were made by Dr. Walter B. James, Mr. Cleveland H. Dodge, and a contributor who wishes to withhold his name, but to whom thanks are none the less due. The Royal Society of London. The Research Grant to the Physiological Department of the University of Toronto. The Moray Fund, Edinburgh. The Carnegie Fund, Edinburgh. Sir Robert Hadfield, Bart., F. R. S. Sir Peter Mackie, Bart.

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Section: Anglosaxons Atmentioning

confidence: 79%

VIII.—Observations upon the effect of high altitude on the physiological processes of the human body, carried out in the Peruvian Andes, chiefly at Carro de Pasco. - Report to the Peru High-Altitude Committee

Barcroft

Binger

Bock

et al. 1923

Phil. Trans. R. Soc. Lond. B

166

View full text Add to dashboard Cite

show abstract

“…The recent arrivals (two weeks) had the smallest average increase above normal, the group of white residents who had lived at high altitudes for a year or more had a greater response, while the natives, who had lived all their lives in the high Andes, exhibited, on the average, the highest red cell counts and hemoglobin concentrations of all. The studies which have been made upon animals also indicate wide individual variation in the erythropoietic response to a given lowering of oxygen pressure (22).…”

Section: Discussionmentioning

confidence: 96%

Pulmonary Gas Diffusion in Polycythemia Vera

Harrop

Heath²,

Schaub³

1927

J. Clin. Invest.

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“…Similarly Douglas, Haldane, Henderson, and Schneider (19) in the Pike's Peak expedition mention no nucleated red cells, though polycythemia was pronounced. Lastly, Loevenhart and his collaborators (20) have made accurate examinations of the effects of low partial pressures of oxygen with normal and with reduced barometric pressures. They obtained polycythemia together with marked marrow hyperplasia "Blood smears from animals showing increased blood counts after exposure to atmospheres poor in oxygen when stained with Jenner stain show a number of basophilic erythrocytes.…”

Section: Nudeated Red Cells In Conditions Not Preceded By Blood Lossmentioning

confidence: 99%

“…And it is to be remembered that Schauman and Rosenqvist (22) by sudden reduction of pressure with no other change in the condition of the animal did find blast extrusion in two cases. Loevenhart and his associates (20) found it impossible to keep animals at oxygen percentages below 7.0. They, however, brought several animals to this minimum, kept them there a week, and include them in their statement as to the blood morphology; i.e., many bluish-stalning forms, no mention of blasts.…”

Section: Nudeated Red Cells In Conditions Not Preceded By Blood Lossmentioning

confidence: 99%

The Factors Concerned in the Appearance of Nucleated Red Blood Corpuscles in the Peripheral Blood

Drinker

Kreutzmann

1918

Journal of Experimental Medicine

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During the winter of 1915-16, while developing a method for isolating the circulation through the tibia of the dog (1), two of us became interested in the active vasomotor control which the vessels of the marrow were shown to possess. At this time we undertook to determine what factors of coagulation (2) arose in the bone marrow, and in order not to complicate conditions physiological salt solution, Ringer's solution, and physiological salt solution containing small amounts of sodium oxalate were used as perfusion fluids. These solutions were delivered to the bone by means of a simple constant pressure apparatus and though usually oxygenated as thoroughly as is possible with such fluids, still it must be considered that they were relatively oxygen-free. Under the conditions of the experiments it was found at once that various characteristic marrow cells appeared in the effluent. Thus, nucleated red blood corpuscles, occasional myelocytes, and even at times megakaryocytes could be identified. Our attention was directed to the question of cellular egress by the observation that vasoconstriction, produced by the addition of small amounts of adrenin to the perfusing fluid, resulted in instant diminution of the number of cells leaving the marrow, and with the characteristic vasodilatation which concludes the reaction a large increase in the number of cells was noted. These findings paralleled those made

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The Mechanism Adapting the Oxygen Capacity of the Blood to the Requirements of the Tissues

Cited by 33 publications

References 0 publications

VIII.—Observations upon the effect of high altitude on the physiological processes of the human body, carried out in the Peruvian Andes, chiefly at Carro de Pasco. - Report to the Peru High-Altitude Committee

VIII.—Observations upon the effect of high altitude on the physiological processes of the human body, carried out in the Peruvian Andes, chiefly at Carro de Pasco. - Report to the Peru High-Altitude Committee

Pulmonary Gas Diffusion in Polycythemia Vera

The Factors Concerned in the Appearance of Nucleated Red Blood Corpuscles in the Peripheral Blood

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