The mechanism behind the antileishmanial effect of zinc sulphate. II. Effects on the enzymes of the parasites

Hummadi, Yassir M. Al-Mulla; Al-Bashir, Nada M.; Najim, Rafid A.

doi:10.1179/136485905x19937

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Several modes of action for Zn(II) complexes with anti-leishmanial properties have been discussed in the literature: some compounds have been reported to inhibit enzymes essential for the parasite's carbohydrate metabolism, such as those involved in the Embden-Meyerhof pathway. 48 Some studies have indicated that Zn(II) complexes selectively recognize anionic cell surfaces through a combination of electrostatic attraction and specific coordination of the zinc cations with phospholipids in the cell membrane. 49,50 Given the changes in parasite morphology effected by the Zn(II) complexes described herein resulting in loss of the distinct shape of the parasite, a structural component of the parasite membrane could be proposed as a plausible target.…”

Section: -Esi †)mentioning

confidence: 99%

Glycosylated metal chelators as anti-parasitic agents with tunable selectivity

et al. 2017

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Trypanosoma cruzi and Leishmania amazonensis are the causative agents of Chagas' disease and leishmaniasis, respectively. These conditions affect millions of people worldwide, especially in developing countries. As such, there is an urgent need for novel, efficient and cost-effective treatments for these diseases, given the growing resistance and side-effects of current therapies. This work details the synthesis and evaluation of the anti-parasitic activity of novel amino- and iminopyridyl metal chelators, their glycosylated derivatives and some of their metal complexes. Our results revealed the potent and metal-dependent activity for the aminopyridyl compounds: Cu(ii) complexes were most effective against T. cruzi trypomastigotes, while Zn(ii) complexes presented excellent activity against L. amazonensis promastigotes. In addition, the compounds showed excellent selectivity indexes and very low relative toxicity as judged by in vitro and in vivo studies, respectively, using RAW macrophages and Galleria mellonella larvae model.

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Section: -Esi †)mentioning

confidence: 99%

Glycosylated metal chelators as anti-parasitic agents with tunable selectivity

et al. 2017

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“…Zinc level is important for T cell, neutrophil, and natural killer cell function. The antileishmanial effect of zinc may result from the inhibition of enzymes that are necessary for the parasites, and these effects are dose dependent [13]. Our study results showed that both treatments (ZS and MA) have moderate cure rate in CL.…”

Section: Discussionmentioning

confidence: 67%

Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

Yazdanpanah

Banihashemi

Pezeshkpoor

et al. 2011

Dermatology Research and Practice

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The purpose of this study was to investigate comparison between oral zinc sulfate and meglumine antimoniate in the treatment of cutaneous leishmaniasis (CL). So 100 patients with CL were included and randomly divided into two groups. The first group was treated with oral zinc sulfate (10 mg/kg/day during 45 days period), and the second group was treated with systemic meglumine antimoniate (20 mg/kg/day intramuscularly for 20 days). Acceptable cure after completing 45 days of followup occurred in 30.2% of lesions in first group, while this was 35.5% for the second group. There is not any significant difference between the two treatment groups (P = 0.42). Serious side effects resulting in treatment discounting occurred in only meglumine antimoniate group. Although cure rate of systemic meglumine antimoniate group was better the treatment with zinc sulfate is much easier, cheaper, more convenient in consumption, safer, and nearly close cure percentage to systemic meglumine antimoniate injections without serious side effect.

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“…In CL, macrophages engulf Leishmania amastigotes which divide inside them [19]. Zinc is known to influence macrophage function [20].…”

Section: Role Of Zinc In Host Immunitymentioning

confidence: 99%

“…Zinc sulfate has a significant inhibitory effect on key enzymes involved in the carbohydrate metabolism and virulence of L. major and L.tropica [20]. The Embden-Meyerhof pathway is one of the important pathways in carbohydrate metabolism.…”

Section: Role Of Zinc In Parasite Metabolism Pathwaymentioning

confidence: 99%

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Anti-Leishmanial Effect of Oral Zinc Sulfate in Acute Cutaneous Leishmaniasis: A Mini-review

Salih¹,

Yousef

2021

IJTDH

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Cutaneous Leishmaniasis (CL) is an endemic parasitic infection caused by various Leishmania species, with a specific predisposition of each species into a particular geographical area. Cutaneous lesions can either be a single, limited skin lesion or multiple, large, locally destructions skin lesions. Several therapies are proposed for CL, but severe side effects, high costs, and incomplete efficacy make researchers find replaceable therapies. Since the usage of zinc sulfate as a therapeutic agent has a long history in treating of various dermatological diseases, Zinc plays an essential role in the development and function of innate immunity cells (neutrophils and natural killer cells), which play significant roles in killing parasites. It also has a significant inhibitory effect on key enzymes involved in the carbohydrate metabolism and virulence of L. major and L.tropica. Therefore, its use as an oral therapy for CL might represent a significant addition to the armamentarium of anti-leishmanial medications. This review summarizes and discusses previous and recent findings regarding the therapeutic roles of oral zinc sulfate in cutaneous leishmaniasis therapy.

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The mechanism behind the antileishmanial effect of zinc sulphate. II. Effects on the enzymes of the parasites

Cited by 10 publications

References 19 publications

Glycosylated metal chelators as anti-parasitic agents with tunable selectivity

Glycosylated metal chelators as anti-parasitic agents with tunable selectivity

Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

Anti-Leishmanial Effect of Oral Zinc Sulfate in Acute Cutaneous Leishmaniasis: A Mini-review

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