The Mechanism by Which Alcohol Stimulates Acid Secretion

Relationship of Antral Motility to Gastrin Activity in Surgically Prepared Dogs

“…On this basis it would appear that a positive relationship exists between gastrin release and antral motility. However, the mechanism of the gastric secretory response to ethyl alcohol is complex and may include histamine release ( 18), gastrin release (19), central vagal stimulation (20), and direct stimulation of the parietal cells (19). The acid secretion elicited from the vagally-denervated pouch, following the intubation of ethyl alcohol into the main stomach may therefore have involved any one or a combination of the factors cited.…”

Stimulation of Gastric Acid Secretion by Acetate

“…Dragstedt et aZ (2) observed that perfusion of organs with dilute alcohol solution resulted in histamine-like activity in the perfusate. Irvine, Watkin and Will i a m (6) , although confirming the gastrin releasing effect of ethanol, did not believe that gastrin was the major factor mediating the acid response to oral or intravenous alcohol. However, Irvine, Watkin and Williams(6) did not detect a rise in free histamine concentration in the urine during alcohol stimulation but a histamine infusion producing equivalent acid response raised urinary histamine levels.…”

“…Radioactive tracer techniques have been used for the study of placental transport of the essential nutrient, calcium, in mice, rats, rabbits and cattle (1)(2)(3)(4). Pregnant monkeys were chosen because of the close similarity of their placental structure to that of humans ( 6,7). This report concerns the simultaneous transfer of isotopi- of California at Los Angeles cally labeled calcium across the placenta from mother to fetus and in the reverse direction.…”

“…Polyethylene catheters were placed in a maternal femoral vein, an interplacental vessel of the: fetus and the amniotic sac in a manner previously described (6). Each of 3 pregnant rhesus monkeys was anesthetized -with intramuscular piperidine HCl (4 mgJkg supplemented with pentobarbital 10 mg/kg body weight).…”

Ethanol-stimulated acid secretion in the isolated whole stomach of the rat

“…Kondo & Magee (1977) have reported that in the conscious dog ethanol-stimulated acid secretion is mediated by the release of antral gastrin, although other workers (Woodward et al 1957;Irvine et al 1960) have found that antrectomy does not abolish this response. Kondo & Magee (1977) have reported that in the conscious dog ethanol-stimulated acid secretion is mediated by the release of antral gastrin, although other workers (Woodward et al 1957;Irvine et al 1960) have found that antrectomy does not abolish this response.…”