The mechanism of 67Ga localization in malignant disease

Weiner, Ronald E.

doi:10.1016/0969-8051(96)00119-9

Cited by 74 publications

(60 citation statements)

References 44 publications

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“…Gallium uptake, now known to be through TFRC1, has been used clinically to image lymphomas in patients (17,55). Since c-Myc is known to play an important role in lym- phomagenesis and both c-Myc and TFRC1 have been linked to the development of aggressive diffuse large B-cell lymphoma (2,32), it is not surprising that TFRC1 has served as a useful clinical marker.…”

mentioning

confidence: 99%

Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

O’Donnell

Zeller

et al. 2006

Molecular and Cellular Biology

217

166

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mentioning

confidence: 99%

Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

O’Donnell

Zeller

et al. 2006

Molecular and Cellular Biology

217

166

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“…In the present study, the Spearman's rho values of less than 0.9 between iron and gallium signals from treated mice suggest that, in the bladder, gallium is partially distributed via mechanisms that do not involve iron. Observations in bone marrow, liver, spleen, and tumor tissues have similarly indicated that gallium and iron are not identically distributed in tissues (15). The positive values obtained for Spearman's rho suggest that inhibition of one metal's distribution by the other is not a large component of the relationship between gallium and iron in the bladder.…”

Section: Discussionmentioning

confidence: 62%

“…This is consistent with a common high-capacity transport system coupled with additional specific pathways to account for the differences in distribution. The common distribution pathway may include transferrin and transferrin receptors, as previously described, while the greater aqueous solubility of gallium than of iron at physiological pH may explain differences in the distribution of non-protein-bound gallium and iron (15).…”

Section: Discussionmentioning

confidence: 97%

“…While gallium distribution has been described in a limited number of tissues, its distribution in the urinary bladder is unknown (15,20). Confirmation of gallium distribution to the transitional epithelium following oral administration of gallium maltolate will support further investigation of gallium maltolate as a new antimicrobial therapy for UTIs caused by UPEC.…”

mentioning

confidence: 99%

“…Unlike iron(III), gallium(III) is not known to undergo reduction under physiological conditions (14). Gallium binds readily to transferrin, and its transport in mammalian tissues is thought to depend on transferrin receptor pathways (15). The similarities between gallium and iron also affect bacterial systems.…”

mentioning

confidence: 99%

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Synchrotron X-Ray Fluorescence Microscopy of Gallium in Bladder Tissue following Gallium Maltolate Administration during Urinary Tract Infection

Ball

Sampieri

Chirino

et al. 2013

Antimicrob Agents Chemother

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A mouse model of cystitis caused by uropathogenic Escherichia coli was used to study the distribution of gallium in bladder tissue following oral administration of gallium maltolate during urinary tract infection. The median concentration of gallium in homogenized bladder tissue from infected mice was 1.93 g/g after daily administration of gallium maltolate for 5 days. Synchrotron X-ray fluorescence imaging and X-ray absorption spectroscopy of bladder sections confirmed that gallium arrived at the transitional epithelium, a potential site of uropathogenic E. coli infection. Gallium and iron were similarly but not identically distributed in the tissues, suggesting that at least some distribution mechanisms are not common between the two elements. The results of this study indicate that gallium maltolate may be a suitable candidate for further development as a novel antimicrobial therapy for urinary tract infections caused by uropathogenic E. coli.

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Tyrosine Hydrogen Bond Properties for the Two Binding Sites of Apoovotransferrin

Qiao

Yang

et al. 2005

Chin. J. Chem.

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The interaction of gallium(III) with the ligands containing phenolic group(s), such as salicylic acid, N, N,glycine (EHPG), and ovotransferrin, was studied, respectively, by means of fluorescence in 0.01 mol/L Hepes at pH 7.4 and room temperature. Fluorescence intensity showed an increase when gallium(III) was bound to 8-hydroxyquinoline and HBED. In contrast, it was decreased with the interaction of gallium(III) with salicylic acid and EHPG. At pH 7.4, there was N…H-O type intramolecular hydrogen bond in the former, and the latter existed O…H-O type intramolecular hydrogen bond. Fluorescence titration of apoovotransferrin with gallium(III) displayed that the fluorescence intensity was decreased at the N-terminal binding site, while enhanced at the C-terminal binding site. It can account for the O…H-O type intramolecular hydrogen bonds for the phenolic groups of Tyr92 and Tyr191 residues at the N-terminal binding site. And there are N…H-O type intramolecular hydrogen bonds for Tyr431 and Tyr524 residues at the C-terminal binding site. In addition, under the same conditions, the conditional binding constant of gallium(III) with EHPG or HBED determined by fluorescence method is lg K Ga-EHPG ＝19.18 or lg K Ga-HBED ＝19.08.

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The mechanism of 67Ga localization in malignant disease

Cited by 74 publications

References 44 publications

Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

Synchrotron X-Ray Fluorescence Microscopy of Gallium in Bladder Tissue following Gallium Maltolate Administration during Urinary Tract Infection

Tyrosine Hydrogen Bond Properties for the Two Binding Sites of Apoovotransferrin

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