The mechanism of acacetin-induced apoptosis on oral squamous cell carcinoma

Identification of 7,8-Diacetoxy-3-Arylcoumarin Derivative as a Selective Cytotoxic and Apoptosis-inducing Agent in a Human Prostate Cancer Cell Line

“…It has also been reported that the interaction between Bcl2 family members, XIAP and Smac/DIABLO, plays a major role in the intrinsic apoptotic pathway (32). Furthermore, activation of Caspase-3, -8, and -9 are the most common processes occurring in the apoptotic signaling events (34,35). The result from our Caspases measurement showed increase in the cells viability with either Caspase 3 (Z-DEVD-fmk) or Caspase 8 (Z-IETD-fmk) inhibitors pretreatment ( Figure 4); indicating the involvement of Caspases 3/8 in compound 5f induced apoptotic cell death of PC-3 cells.…”

Luteoloside Inhibits Proliferation of Human Chronic Myeloid Leukemia K562 Cells by Inducing G2/M Phase Cell Cycle Arrest and Apoptosis

“…High expression of pro-apoptotic Bcl-2 family proteins can enhance the permeability of outer mitochondrial membrane and the consequent translocation of cytochrome c from the mitochondria to the cytoplasm, which provokes the downstream apoptotic events, while the anti-apoptotic Bcl-2 family proteins oppose the pro-apoptotic Bcl-2 family proteins [25][26][27]. Increasing Bax/Bcl-2 ratio often accompanies phytochemical-induced apoptosis through mitochondrial pathway in cancer cells [28][29][30].…”

Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

“…Acacetin inhibits cell proliferation and induces cell apoptosis in breast cancer cells (Shim et al, ), prostate cancer cells (Shen et al, ; Singh, Agrawal, Yim, Agarwal, & Agarwal, ), nonsmall cell lung cancer cells (Hsu, Kuo, Liu, & Lin, ), hepatocellular carcinoma cells (Hsu, Kuo, & Lin, ), gastric carcinoma cells (Pan, Lai, Hsu, & Wang, ), and oral squamous cell carcinoma cells (Kim, Cha, Li, & Cha, ). It has been reported that the acacetin‐induced apoptosis of oral squamous cell carcinoma cell line is closely related to the activation of the MAPK‐mediated signaling pathways with the subsequent induction of a mitochondria‐ and caspase‐dependent mechanism (Kim et al, ). Herein, our results showed that acacetin is effective on HNSCC cell lines, inhibiting cell viability and inducing apoptosis.…”