The mechanism of action of chlorhexidine

Kuyyakanond, Thicumporn; Quesnel, L. B.

doi:10.1111/j.1574-6968.1992.tb14042.x

Cited by 79 publications

(11 citation statements)

References 8 publications

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“…Thus, at low concentrations, chlorhexidine has bacteriostatic action (inhibits bacterial growth) by disrupting the cell membrane. 13 At high concentrations, chlorhexidine causes the coagulation of cytoplasmic proteins, probably through denaturation; its action is bactericidal. 13 As the Gram-positive bacteria Streptococcus mutans are sensitive to chlorhexidine, chlorhexidine is the most widely used agent against dental plaque.…”

Section: Introductionmentioning

confidence: 99%

“…13 At high concentrations, chlorhexidine causes the coagulation of cytoplasmic proteins, probably through denaturation; its action is bactericidal. 13 As the Gram-positive bacteria Streptococcus mutans are sensitive to chlorhexidine, chlorhexidine is the most widely used agent against dental plaque. [14][15][16][17] Thus, chlorhexidine salts, especially the digluconate, are reported as not only being used as the active ingredient in mouthwashes, but also in shampoos, body lotions and face cleansers.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

Mihalache

Negreanu–Pîrjol

Dumitraşcu

et al. 2018

JSCS

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Six new coordination compounds of Ni(II), Pd(II) and Cr(III) with chlorhexidine, 1,1′-hexamethylenebis[5-(4-chlorophenyl)biguanide], were prepared, characterized and examined for their potential as antimicrobial agents, as well as for their antioxidant activity. The metal complexes correspond to the formulas: [Ni(CHX)]Cl 2 •2H 2 O, [Ni(CHX)]Br 2 •2H 2 O, [Ni(CHX)](CH 3 COO) 2 •C 2 H 5 OH, [Pd(CHX)][PdCl 4 ]•2H 2 O, [Pd(CHX)](CH3COO) 2 and [Cr(CHX)Cl 2 ](CH 3 COO), where CHX = chlorhexidine. Investigations on the in vitro antimicrobial activity of the complexes indicated that all have high activity against the tested bacteria, but are less active against fungi. Among the six complexes, those of Pd(II) showed the highest antibacterial activity, [Pd(CHX)][PdCl 4 ]•2H 2 O being more active against Gram-positive and Gram-negative bacteria than chlorhexidine diacetate. The antioxidant activity of the metal complexes was investigated by photochemiluminescence and the results showed that the palladium(II) complexes have high antioxidant activities.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

Mihalache

Negreanu–Pîrjol

Dumitraşcu

et al. 2018

JSCS

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“…CHX is a chemical antiseptic which is effective against Gram‐positive and Gram‐negative bacterial strains . The mechanisms of action of CHX are bactericidal as well as bacteriostatic causing membrane disruption . CHX is the “gold standard” and it is widely used and receives great attention in periodontal therapy due to its potency against bacterial plaque .…”

Section: Introductionmentioning

confidence: 99%

“…[16,17] The mechanisms of action of CHX are bactericidal as well as bacteriostatic causing membrane disruption. [18] CHX is the "gold standard" and it is widely used and receives great attention in periodontal therapy due to its potency against bacterial plaque. [19][20][21] For the prophylaxis against wound infections, CHX is used as pre-operative whole-body disinfection.…”

Section: Introductionmentioning

confidence: 99%

Chlorhexidine Loaded Cyclodextrin Containing PMMA Nanogels as Antimicrobial Coating and Delivery Systems

et al. 2016

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Antimicrobial nanogels, aggregates, and films are prepared by complexation of the antiseptic and bacteriostatic agent chlorhexidine (CHX) for medical and dental applications. A series of α-, β-, and γ-cyclodextrin methacrylate (CD-MA) containing hydrophobic poly(methyl methacrylate) (PMMA) based nanogels are loaded quantitatively with CHX in aqueous dispersion. The results show that CHX is enhancedly complexed by the use of CD-MA domains in the particles structure. β-CD-MA nanogels present the highest uptake of CHX. Furthermore, it is observed that the uptake of CHX in nanogels is influenced by the hydrophobic PMMA structure. CHX acts as external cross-linker of nanogels by formation of 1:2 (CHX:CD-MA) inclusion complexes of two β-CD-MA units on the surfaces of two different nanogels. The nanogels adsorb easily onto glass surfaces by physical self-bonding and formation of a dense crosslinked nanogel film. Biological tests of the applied CHX nanogels with regard to antimicrobial efficiency are successfully performed against Staphylococcus aureus.

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“…Its antimicrobial action can be attributed to a disruption of the bacterial cell membrane, thereby interfering with bacterial adhesion. [3] Consequently, there is a need to find effective methods of biomaterial surface modifications, which will allow them to be coated with antibacterial agents such as CHX that meet the specific demands of an application. [7 -9] A surface modification technique that shows promise is polymer spray coating, which has the advantage of control over the release kinetics through variations of the coating and its components.…”

Section: Introductionmentioning

confidence: 99%

The release behavior of CHX from polymer‐coated titanium surfaces

Kim

Lee

et al. 2008

Surface & Interface Analysis

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Titanium has been successfully used in dental implants due to its favorable biological response. However, implant failures caused by infection often occurred with a complex microbial exposure. Chlorhexidine (CHX) is effective against a wide variety of bacteria as well as fungi. The aim of the present study is to investigate the release behavior of CHX from CHX-containing polylactide (PLA)-coated titanium. Commercially, pure titanium was anodized with surfaces exposed to an anodic-forming voltage of 250 V for 3 min. The anodized titanium surfaces were then coated with a PLA/CHX solution. Topographic evaluation was performed using a SEM, and the antibacterial effect was evaluated. The concentrations of CHX were measured using a UV spectrophotometer. In the surface morphology analysis, the uncoated titanium surface showed a porous structure, but the surfaces coated with a polymer displayed nonporous structures and wrinkled surfaces. In addition, there were no differences in the surface roughness between the uncoated and coated surface. On the basis of the comparative analysis of both the UV absorbance of CHX and the surface characteristics, we concluded that the PLA coating can effectively control the release of CHX on anodized titanium surfaces.

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The mechanism of action of chlorhexidine

Cited by 79 publications

References 8 publications

Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

Chlorhexidine Loaded Cyclodextrin Containing PMMA Nanogels as Antimicrobial Coating and Delivery Systems

The release behavior of CHX from polymer‐coated titanium surfaces

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