The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review

Li, Juan; Sun, Mingsheng; Ye, Jing; Li, Yuxi; Jin, Rongjiang; Zheng, Hui; Liang, Fanrong

doi:10.1155/2019/8676490

Cited by 37 publications

(27 citation statements)

References 98 publications

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“…Therefore, it's hard to say which of these two aspects (the flora and the host) is the direct target of acupuncture. A recent review [ 69 ] summarized the mechanism of acupuncture in treating hypertension and found that renin–angiotensin–aldosterone system (RAAS), vascular endothelium, oxidative stress response, neuroendocrine system are all involved in the antihypertensive mechanisms of acupuncture while these mechanisms themselves are influenced by gut microbiota. In addition, previous studies showed EA could stimulate more SCFAs and improve the digestion.…”

Section: Discussionmentioning

confidence: 99%

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

Wang

Yang

et al. 2021

Chin Med

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Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota. Results In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes. Conclusions Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture. Trial registration: Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726

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Section: Discussionmentioning

confidence: 99%

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

Wang

Yang

et al. 2021

Chin Med

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“…It has been suggested that induction of 2-AG release in endothelium occurs in parallel to nitric oxide (NO) and involves activation of cholinergic receptors 88 . Nitric oxide, the most effective endothelium derived relaxing factor (EDRF), and endothelial derived hyperpolarizing factor (EDHF) 89 have a close functional relationship with ET-1 in regulating the endothelial-dependent capillary and microvascular responses in the brain 90 .…”

Section: Ecb In Neuroinflammationmentioning

confidence: 99%

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2020

IJPSR

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In aerobic organisms, oxygen is essential for sufficient energy production but self-contradictory, produces chronic toxic stress in cells. So, protective techniques must exist for removal of toxic free radicals which are byproducts of oxygen. Diverse protective systems have evolved to enable adaptation of antioxidant activity. Tissues and organs have different rates of metabolic activity and oxygen consumption. Their levels of antioxidants are also different. Such is the case with glutathione (GSH) and cysteine, which are lower in the brain than the liver, kidney, or muscle. Investigations of oxidative responses in different complex organisms such as mammals, organs, and tissues which contain distinct antioxidant systems and this may form the basis for differential susceptibility to toxic agents. Notable advances have been made in our understanding of these distinct systems, with several antioxidant systems and their regulatory pathways being described at the cellular level, thus understanding the pathways leading to the induction of antioxidant responses will enable development of strategies to protect against oxidative damage.

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“…Network pharmacology is widely used in drug discovery, mechanism research and target prediction, especially in TCM [ 5 , 78 ]. Relevant studies have recently proved that acupuncture involves multiple systems of the human body and has multi-target therapeutic effects, therefore, it is urgent to introduce novel research ideas into the research of the potential mechanisms of acupuncture [ 41 ]. In this study, we aimed to reveal the molecular mechanisms of acupuncture against COVID-19 through bioinformatics, network topology and network pharmacology approach, in order to further deepen the current understanding of the therapeutic nature of acupuncture on COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Is acupuncture effective in the treatment of COVID-19 related symptoms? Based on bioinformatics/network topology strategy

Han

Zhang

Wang

et al. 2021

Briefings in Bioinformatics

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Acupuncture is an important part of Chinese medicine that has been widely used in the treatment of inflammatory diseases. During the coronavirus disease 2019 (COVID-19) epidemic, acupuncture has been used as a complementary treatment for COVID-19 in China. However, the underlying mechanism of acupuncture treatment of COVID-19 remains unclear. Based on bioinformatics/topology, this paper systematically revealed the multi-target mechanisms of acupuncture therapy for COVID-19 through text mining, bioinformatics, network topology, etc. Two active compounds produced after acupuncture and 180 protein targets were identified. A total of 522 Gene Ontology terms related to acupuncture for COVID-19 were identified, and 61 pathways were screened based on the Kyoto Encyclopedia of Genes and Genomes. Our findings suggested that acupuncture treatment of COVID-19 was associated with suppression of inflammatory stress, improving immunity and regulating nervous system function, including activation of neuroactive ligand–receptor interaction, calcium signaling pathway, cancer pathway, viral carcinogenesis, Staphylococcus aureus infection, etc. The study also found that acupuncture may have additional benefits for COVID-19 patients with cancer, cardiovascular disease and obesity. Our study revealed for the first time the multiple synergistic mechanisms of acupuncture on COVID-19. Acupuncture may play an active role in the treatment of COVID-19 and deserves further promotion and application. These results may help to solve this pressing problem currently facing the world.

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The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review

Cited by 37 publications

References 98 publications

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

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Is acupuncture effective in the treatment of COVID-19 related symptoms? Based on bioinformatics/network topology strategy

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