The mechanism of adhesion and graft polymerization of a PNIPAAm thermoresponsive hydrogel to polypropylene meshes

Lanzalaco, Sonia; Turón, Pau; Weis, Christine; Alemán, Carlos; Armelín, Elaine

doi:10.1039/c9sm00412b

Cited by 30 publications

(58 citation statements)

References 42 publications

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“…Following the previous results, 11 in this section, we prove that the control of the polymerization time is of fundamental relevance to get not only iPP fibres with hydrogel covalently bonded to the PP matrix, but also with mesh pores free of hydrogel. Like in Section 3.1, the effects of the grafting time on the gel deposition and morphology were examined by using optical microscopy and SEM.…”

Section: Effect Of Grafting Time For the Deposition Of Pnipaam On Thesupporting

confidence: 81%

“…The pristine Optilene s Mesh LP was first activated with oxygen plasma (plasma power 250 W, purging pressure of 0.07 mbar, gas flow fixed for 180 s and 20 sccm). 11 After plasma treatment, all samples were stored under vacuum for a few days, if not used immediately for the deposition of the soft hydrogel PNIPAAm.…”

Section: Preparation Of the Pp Mesh Grafted Withmentioning

confidence: 99%

“…The aspect of the PP mesh after PNIPAAm/MBA covalent bonding is completely transparent, as shown in our previous study. 11…”

Section: Preparation Of the Pp Mesh Grafted Withmentioning

confidence: 99%

“…In a previous study, 11 we successfully prepared a novel surgical mesh, composed by a commercial light-weight PP substrate and a thermoresponsive hydrogel, poly(N-isopropylacrylamide-co-N,N 0methylene bis(acrylamide) (PNIPAAm-co-MBA). 12 The new hardsoft bilayer system was designed to reduce the problems of organ adhesion, discussed above, after mesh implantation.…”

Section: Introductionmentioning

confidence: 99%

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Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

et al. 2020

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Herein, a versatile bilayer system, composed by a polypropylene (PP) mesh and a covalently bonded poly(N-isopropylacrylamide) (PNIPAAm) hydrogel, is reported. The cell adhesion mechanism was successfully modulated by controlling the architecture of the hydrogel in terms of duration of PNIPAAm grafting time, crosslinker content, and temperature of material exposure in PBS solutions (below and above the LCST of PNIPAAm). The best in vitro results with fibroblast (COS-1) and epithelial (MCF-7) cells was obtained with a mesh modified with a porous iPP-g-PNIPAAm bilayer system, prepared via PNIPAAm grafting for 2 h at the lowest N,N 0 -methylene bis(acrylamide) (MBA) concentration (1 mM). Under these conditions, the detachment of the fibroblast-like cells was 50% lower than that of the control, after 7 days of cell incubation, which represents a high de-adhesion of cells in a short period. Moreover, the whole system showed excellent stability in dry or wet media, proving that the thermosensitive hydrogel was well adhered to the polymer surface, after PP fibre activation by cold plasma. This study provides new insights on the development of anti-adherent meshes for abdominal hernia repair.

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Section: Effect Of Grafting Time For the Deposition Of Pnipaam On Thesupporting

confidence: 81%

Section: Preparation Of the Pp Mesh Grafted Withmentioning

confidence: 99%

“…The aspect of the PP mesh after PNIPAAm/MBA covalent bonding is completely transparent, as shown in our previous study. 11…”

Section: Preparation Of the Pp Mesh Grafted Withmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

et al. 2020

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“…Additionally, plasma can easily treat objects with complex geometries and high surface areas. Numerous studies have therefore explored plasma surface treatments for surgical meshes (Avetta et al, 2014;Binnebösel et al, 2012Binnebösel et al, , 2010Gorgieva et al, 2015;Hu et al, 2017;Junge et al, 2007;Kulaga et al, 2014;Kumar et al, 2013;Labay et al, 2015;Lanzalaco et al, 2019;Lu et al, 2019;Nisticò et al, 2017Nisticò et al, , 2015Nisticò et al, , 2013Nisticò et al, , 2012Paul et al, 2010;Rivolo et al, 2016;Sanbhal et al, 2019Sanbhal et al, , 2018bSannino et al, 2005;Zhang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Nonthermal plasma treatment of polymers modulates biological fouling but can cause material embrittlement

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Wilson

et al. 2019

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Plasma-based treatment is a prevalent strategy to alter biological response and enhance biomaterial coating quality at the surfaces of biomedical devices and implants, especially polymeric materials. Plasma, an ionized gas, is often thought to have negligible effects on the bulk properties of prosthetic substrates given that it alters the surface chemistry on only the outermost few nanometers of material. However, no studies to date have systematically explored the effects of plasma exposure on both the surface and bulk properties of a biomaterial. This work examines the time-dependent effects of a nonthermal plasma on the surface and bulk properties of polymeric implants, specifically polypropylene surgical meshes and sutures. Findings suggest that plasma exposure improved resistance to fibrinogen adsorption and Escherichia coli attachment, and promoted mammalian fibroblast attachment, although increased duration of exposure resulted in a state of diminishing returns. At the same time, it was observed that plasma exposure can be detrimental to the material properties of individual filaments (i.e. sutures), as well as the structural characteristics of knitted meshes, with longer exposures resulting in further embrittlement and larger changes in anisotropic qualities. Though there are few guidelines regarding appropriate mechanical properties of surgical textiles, the results from this investigation imply that there are ultimate exposure limits for plasma-based treatments of polymeric implant materials when structural properties must be preserved, and that the effects of a plasma on a given biomaterial should be examined carefully before translation to a clinical scenario.

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Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

et al. 2023

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Temperature‐sensitive (thermosensitive) hydrogels, which are part of the family of stimulus‐sensitive hydrogels, consist of water‐filled polymer networks that display a temperature‐dependent degree of swelling. Thermosensitive hydrogels, which can undergo phase transition or swell/de‐swell as temperature changes, have great potential in various technological and biomedical purposes for a number of reasons: their temperature response is reversible, hydrogels are stable and easy to prepare, they can be biocompatible and also be suitably combined with other organic and inorganic materials, resulting in new materials with outstanding properties. Among thermosensitive hydrogels poly(N‐isopropylacrylamide) (PNIPAAm) is the most extensively studied because it brings together the best properties of these materials. Consequently, in the past few years, a wide number of applications and new chemical processes to prepare PNIPAAm and their derivatives are being proposed. The objective of this review is to summarize the fundamentals of thermosensitive hydrogels and recent advances in preparation and both technological and biomedical applications of thermosensitive hydrogel, with a special focus on PNIPAAm and their derivatives. Special attention has been given to the discussion of challenges and future research perspectives based on new horizons not yet considered.

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The mechanism of adhesion and graft polymerization of a PNIPAAm thermoresponsive hydrogel to polypropylene meshes

Abstract: In this study, a commercial and fully flexible monofilament mesh has been used for the deposition of a thermosensitive hydrogel, generated by graft copolymerization of N-isopropylacrylamide (NIPAAm) and N,N′-methylene bis(acrylamide) (MBA) monomers.

Cited by 30 publications

References 42 publications

Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

Nonthermal plasma treatment of polymers modulates biological fouling but can cause material embrittlement

Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

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