The Mechanism of Ameliorating the Metabolism by the Medium-chain Fatty Acid via Pathways Related to Energy Production and the Epigenetics

Mochizuki, Kazuki; Kimura, Mayu; Kawamura, Musashi; Hariya, Nastuyo; Goda, Toshinao

doi:10.5650/oleoscience.18.375

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…The improvement in EE digestibility agreed with the results observed in ducks during days 18-38, following the increasing inclusion levels of defatted BSFM (7). A recent study revealed that the fat derived from BSFM is rich in mediumchain fatty acids that can have a positive effect on increasing the energy availability in the intestine (17,25), thus promoting growth performance. However, full-fatted BSFM meal included in duck diets by as much as 9% displayed an inhibited effect on the digestibility of CP and EE of chickens at 42 days of age.…”

Section: Discussionsupporting

confidence: 84%

Evaluation of the Low Inclusion of Full-Fatted Hermetia illucens Larvae Meal for Layer Chickens: Growth Performance, Nutrient Digestibility, and Gut Health

Xiao-hua

Wang

et al. 2020

Front. Vet. Sci.

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Substitution of feed protein source with defatted black soldier fly larvae meal (BSFM) has been evaluated intensively in poultry, but information about full-fatted BSFM is still very limited. The aim of the present study was to investigate the effect of dietary low inclusion of full-fatted BSFM on the growth performance, plasma antioxidant ability, nutrient digestibility, and gut health of layer chickens during 1–42 days of age. A total of 480 female 1-day-old Hy-Line Brown chickens were divided into four dietary treatments, with the inclusion of 0, 3, 6, and 9% of full-fatted BSFM. Each treatment included six replicates and 20 birds per replicate. As dietary full-fatted BSFM inclusion levels increased, there was a quadratic increase in final weight and average daily gain and a quadratic decrease in feed/gain ratio. Dietary full-fatted BSFM inclusion levels increased the digestibility of crude protein and ether extract quadratically as well as ileum mucosal sIgA concentration linearly, but these had no effect on intestinal morphology. Additionally, an increase in dietary full-fatted BSFM inclusion levels resulted in a linear increase in glutathione peroxidase and total superoxide dismutase activities and a linear decrease in malondialdehyde content in plasma. The encouraging results of the improvement of growth performance, nutrient digestibility, antioxidant ability, and gut health parameters suggested that partially full-fatted BSFM inclusion can be suitable protein ingredients for layer chickens' diets at the starter period.

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Section: Discussionsupporting

confidence: 84%

Evaluation of the Low Inclusion of Full-Fatted Hermetia illucens Larvae Meal for Layer Chickens: Growth Performance, Nutrient Digestibility, and Gut Health

Xiao-hua

Wang

et al. 2020

Front. Vet. Sci.

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“…MCFAs are absorbed through the portal system and quickly provide energy to the liver, thereby inhibiting hepatic fat accumulation as well as the development of dyslipidemia [16]. MCFAs have also been reported to activate energy metabolism by themselves, and their metabolites modify histone acetylation [43,44]. RJ contains several characteristic MCFAs.…”

Section: Discussionmentioning

confidence: 99%

Effects of Royal Jelly on Gut Dysbiosis and NAFLD in db/db Mice

et al. 2023

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Royal jelly (RJ) is a naturally occurring substance synthesized by honeybees and has various health benefits. Herein, we focused on the medium-chain fatty acids (MCFAs) unique to RJ and evaluated their therapeutic efficacy in treating non-alcoholic fatty liver disease (NAFLD). We examined db/m mice that were exclusively fed a normal diet, db/db mice exclusively fed a normal diet, and db/db mice fed varying RJ quantities (0.2, 1, and 5%). RJ improved NAFLD activity scores and decreased gene expression related to fatty acid metabolism, fibrosis, and inflammation in the liver. RJ regulated innate immunity-related inflammatory responses in the small intestine and decreased the expression of genes associated with inflammation and nutrient absorption transporters. RJ increased the number of operational taxonomic units, the abundance of Bacteroides, and seven taxa, including bacteria that produce short-chain fatty acids. RJ increased the concentrations of RJ-related MCFAs (10-hidroxy-2-decenoic acid, 10-hydroxydecanoic acid, 2-decenedioic acid, and sebacic acid) in the serum and liver. These RJ-related MCFAs decreased saturated fatty acid deposition in HepG2 cells and decreased the gene expression associated with fibrosis and fatty acid metabolism. RJ and RJ-related MCFAs improved dysbiosis and regulated the expression of inflammation-, fibrosis-, and nutrient absorption transporter-related genes, thereby preventing NAFLD.

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The Mechanism of Ameliorating the Metabolism by the Medium-chain Fatty Acid via Pathways Related to Energy Production and the Epigenetics

Cited by 2 publications

References 7 publications

Evaluation of the Low Inclusion of Full-Fatted Hermetia illucens Larvae Meal for Layer Chickens: Growth Performance, Nutrient Digestibility, and Gut Health

Evaluation of the Low Inclusion of Full-Fatted Hermetia illucens Larvae Meal for Layer Chickens: Growth Performance, Nutrient Digestibility, and Gut Health

Effects of Royal Jelly on Gut Dysbiosis and NAFLD in db/db Mice

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