The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy

Duan, Hongwei; Yang, Shanshan; Yang, Shuai; Zeng, Jianlin; Yan, Zhenxing; Zhang, Lihong; Ma, Xiaofei; Dong, Weitao; Zhang, Yong; Zhao, Xingxu; Hu, Junjie; Xiao, Longfei

doi:10.1016/j.phymed.2024.155468

Phytomedicine

2024

DOI: 10.1016/j.phymed.2024.155468

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The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy

Hongwei Duan,

Shanshan Yang,

Shuai Yang

et al.

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2024

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Cited by 3 publications

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Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Wu,

Guo,

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Wu,

Guo,

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Proanthocyanidins protects 3-NPA-induced ovarian function decline by activating SESTRIN2-NRF2-mediated oxidative stress in mice

Huang,

Cui,

Huang

et al. 2024

Sci Rep

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Abnormal apoptosis of ovarian cells caused by oxidative stress is an important cause of premature ovarian failure (POF). Previous studies revealed that proanthocyanidins (PCs) are powerful natural antioxidants that can safely prevent oxidative damage in humans. However, the protective effect and mechanism of PCs on ovarian function during the course of POF remain unknown. In this study, female mice were injected with 3-nitropropionic acid (3-NPA) to establish an ovarian oxidative stress model; at the same time, the mice were treated with PC via gavage. Thereafter, the expression of various apoptosis genes, hormones, and related molecules was assessed. Compared with those in the control group, the ovarian index, follicle count at all levels, expression of MVH, PCNA and BCL2, and estradiol (E2) and progesterone (P) levels were significantly lower in the POF group, but significant recovery was observed in terms of MVH and PCNA expression and E2 and P levels in the POF + PCs group. The apoptosis marker genes BAX and ROS were significantly increased in the POF group but were notably restored in the POF + PCs group. In addition, the expression of Sestrin2, an antiapoptotic protein, was significantly increased in the PCs treatment group, as were the upstream and downstream regulatory factors NRF2 and SOD2, and the indices of the Sestrin2 overexpression group were similar to those of the PCs treatment group. In summary, these findings suggest that PCs have potential as innovative therapeutic agents for preventing and treating POF by activating the protective SESTRIN2-NRF2 pathway against oxidative stress.

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Natural plant polyphenols contribute to the ecological and healthy swine production

Mei,

Li,

et al. 2024

J Animal Sci Biotechnol

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The absence of trace amounts of natural bioactive compounds with important biological activities in traditional dietary models for global farm animals, coupled with an incomplete theoretical system for animal nutrition, has led to unbalanced and inadequate animal nutrition. This deficiency has adversely impacted animal health and the ecological environment, presenting formidable challenges to the advancement of the swine breeding industry in various countries around the world toward high-quality development. Recently, due to the ban of antibiotics for growth promotion in swine diets, botanical active compounds have been extensively investigated as feed additives. Polyphenols represent a broad group of plant secondary metabolites. They are natural, non-toxic, pollution-free, and highly reproducible compounds that have a wide range of physiological functions, such as antioxidant, anti-inflammatory, immunomodulatory, antiviral, antibacterial, and metabolic activities. Accordingly, polyphenols have been widely studied and used as feed additives in swine production. This review summarizes the structural characteristics, classification, current application situation, general properties of polyphenols, and the latest research advances on their use in swine production. Additionally, the research and application bottlenecks and future development of plant polyphenols in the animal feed industry are reviewed and prospected. This review aims to stimulate the in-depth study of natural plant polyphenols and the research and development of related products in order to promote the green, healthy, and high-quality development of swine production, while also providing ideas for the innovation and development in the theoretical system of animal nutrition.

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The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy

Cited by 3 publications

References 54 publications

Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Proanthocyanidins protects 3-NPA-induced ovarian function decline by activating SESTRIN2-NRF2-mediated oxidative stress in mice

Natural plant polyphenols contribute to the ecological and healthy swine production

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