The Mechanism of Liver Injury in Mice Caused by Lanthanoids

Fei, Min; Li, Na; Ze, Yuguan; Liu, Jie; Wang, Sisi; Gong, Xiuaolan; Duan, Yanmei; Zhao, Xiaoyang; Wang, Han; Hong, Fashui

doi:10.1007/s12011-010-8698-x

Cited by 28 publications

(16 citation statements)

References 22 publications

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“…However, whether 4f electronic shell and alterable valence characteristics of Ln exert special toxicity on animals has not been carefully investigated. Recently, our researches showed that exposure to Ln damaged spleen, lung, liver, and brain of mice, which was greatest in Ce 3+ treatment, medium in Nd 3+ treatment, and least in La 3+ treatment [11][12][13][14][15]. However, little is known about the effects of Ln on several organs damages simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Organ Histopathological Changes and its Function Damage in Mice Following Long-term Exposure to Lanthanides Chloride

Cheng

Cai

et al. 2011

Biol Trace Elem Res

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Due to increasing applications of lanthanides (Ln) in industry and daily life, numerous studies confirmed that Ln exposure may result in organ damages in mice and rats, while very few studies focused on several organs damages simultaneously. In order to compare the toxicity of Ln on organs, mice were exposed to LaCl(3), CeCl(3), and NdCl(3) of a dose of 20 mg/kg body weight for consecutive 60 days, respectively, then histopathological changes of liver, kidney, and heart, and their function were investigated. The results showed that long-term exposure to Ln caused cell necrosis and basophilia of liver, ambiguity of renal tubule architecture, congestion of blood vessel and capillary of kidney, and heart hemorrhage. The histopathological changes of liver, kidney, and heart in mice caused by Ce(3+) was most severe; the effect by Nd(3+) was slighter than Ce(3+) but more severe than La(3+). The assay of serum biochemical parameters suggested that Ln exposure severely impaired the functions of liver, kidney, and myocardium in mice. These findings suggested that long-term exposure to Ln resulted in histopathological changes of liver, kidney, and heart, and their function damages. Therefore, we thought that long-term application of the products containing Ln on human should be cautious.

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Section: Introductionmentioning

confidence: 99%

Organ Histopathological Changes and its Function Damage in Mice Following Long-term Exposure to Lanthanides Chloride

Cheng

Cai

et al. 2011

Biol Trace Elem Res

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“…Our previous studies demonstrated that abdominal exposure to La 3+ , Ce 3+ , and Nd 3+ at dose of 20 mg/kg BW for 14 days caused oxidative stress in the mouse spleen, liver, brain, and hepatic inflammatory responses. Among the three treatments, the Ce 3+ -treated group exhibited the most severe damage, next in the Nd 3+ -treated group, and the least in the La 3+ -treated group [13][14][15][16]. However, these studies did not refer to the neurotoxicity of cerium under this dosage.…”

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confidence: 99%

The Toxicological Effects in Brain of Mice Following Exposure to Cerium Chloride

Zhao

Cheng

et al. 2011

Biol Trace Elem Res

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Cerium (Ce) compounds are now widely applied in medicine, agriculture, animal breeding, and daily life; however, the effects of Ce on human body, especially on the central nervous system, are still unclear. In order to investigate whether Ce exposure cause neurotoxicological effects, ICR mice were exposed to CeCl(3) through intragastric administration at 0, 2, 10, and 20 mg/kg body weight doses everyday for 60 days. The behaviors of spatial recognition memory, brain histopathology, the brain elements and neurochemicals, as well as enzymes activities in mice were determined. The Y-maze test showed that CeCl(3) exposure could significantly impair the behaviors of spatial recognition memory. Specifically, in these Ln(3+)-treated mice, the contents of Ca, Mg, Na, K, Fe, and Zn in brain were significantly altered, the activities of Na(+)/K(+)-ATPase, Ca(2+)-ATPase, Ca(2+)/Mg(2+)-ATPase, acetylcholine esterase, and nitric oxide synthase were significantly inhibited; monoamines neurotransmitters such as norepinephrine, dopamine, and 5-hydroxytryptamine were significantly decreased, while the contents of acetylcholine, glutamate, and nitric oxide were significantly increased. These results indicated that CeCl(3) exposure could impair the learning ability, which is attributed to the disturbance of the homeostasis of trace elements, enzymes, and neurotransmitter systems in the mouse brain. Therefore, our study aroused the attention of Ln application and long-term exposure effects.

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“…Serum GPT, AST, ALP, LDH, and TG are all used for clinical indication of injuries of liver. 26 BUN is an important indicator of renal function. 27 Increased GPT, AST, ALP, LDH, TG, and HIS in MWWE-treated mice indicated that MWWE exposure resulted in dysfunction of liver.…”

Section: ■ Discussionmentioning

confidence: 99%

Evaluation of the Toxic Effects of Municipal Wastewater Effluent on Mice Using Omic Approaches

Zhang

Huang

Deng

et al. 2013

Environ. Sci. Technol.

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Municipal wastewater effluents (MWWE) contain a lot of trace organic pollutants, which will be a threat to environmental health. However, little information is available for the mixed toxicity of MWWE on mammals. In the present study, male mice were exposed to MWWE for 90 days, and then, histopathology and clinical biochemistry determination and transcriptomic and metabolomic profiling were conducted. The results showed that MWWE exposure resulted in injuries in liver and kidney. Combined transcriptomic and metabolomic data demonstrated that MWWE exposure induced perturbations of metabolism, including lipid, nucleotide, amino acid, and energy metabolism. Furthermore, dysregulation of signal transduction processes were also identified based on differentially expressed genes. These results suggested that chronic exposure to MWWE could induce hepatotoxicity and nephrotoxicity in mice and omic approaches are of practical value to evaluate the complex toxicity of MWWE.

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The Mechanism of Liver Injury in Mice Caused by Lanthanoids

Cited by 28 publications

References 22 publications

Organ Histopathological Changes and its Function Damage in Mice Following Long-term Exposure to Lanthanides Chloride

Organ Histopathological Changes and its Function Damage in Mice Following Long-term Exposure to Lanthanides Chloride

The Toxicological Effects in Brain of Mice Following Exposure to Cerium Chloride

Evaluation of the Toxic Effects of Municipal Wastewater Effluent on Mice Using Omic Approaches

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