The Mechanism of Nano-drug Delivery

Li, Siying; Wang, Hongda; Shan, Yuping

doi:10.1007/s40495-019-00205-5

Cited by 4 publications

(1 citation statement)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only a small fraction of drugs actually reaches their intended targets (cells or tissues). In recent years, nano-drugs have gained a great deal of popularity due to the fact that they can be used as delivery vehicles (Li et al, 2019). By encapsulating or attaching therapeutic medications to nanostructures they can be delivered to target tissues more precisely and released in a controlled manner (Mu et al, 2020).…”

Section: Methotrexate As Nanodrugmentioning

confidence: 99%

Potential Effects of Methotrexate on Health: A Review

Payal,

Girima

2023

Intern. J. Zool. Invest.

View full text Add to dashboard Cite

Methotrexate (MTX) is a metabolite that functions as an antifolate, impeding DNA synthesis, repair, and cell replication. Its clinical uses include rheumatoid arthritis treatment and cancer treatments due to its anti-folate mechanism of action. This medication serves as the primary disease-modifying antirheumatic drug (DMARD) for individuals afflicted with dermatological, inflammatory, and autoimmune conditions. Methotrexate has a unique mode of action, both in terms of its usage as a chemotherapeutic drug and as an immunosuppressant, in the management of autoimmune disorders. It can be combined with anti-TNF (Tumour Necrosis Factor) drugs and used as an off-label treatment for graft-versus-host disease. However, there are limitations to its usage, such as increased toxicity problems and brief plasma life. Methotrexate can be used as a nano-drug to decrease administration frequency while maximizing pharmacological effects and minimizing systemic side effects. The utilization of nanodrugs has been found to be more efficacious in comparison to intra-articular or oral delivery methods. Additionally, it has been determined that the co-loading of MTX-SPIONs (Superparamagnetic iron oxide nanoparticles) in NLC (Nanostructured lipid carriers) has been found to be a viable carrier for the delivery of MTX. The present review focuses on potential effects of methotrexate on health.

show abstract

Section: Methotrexate As Nanodrugmentioning

confidence: 99%