The Mechanism of the Action of Anaesthetics

Burge, W. E.; Neill, A. J.; Ashman, Richard

doi:10.1152/ajplegacy.1918.45.4.388

Cited by 6 publications

(1 citation statement)

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“…at low temperatures, to the fact that their Teilungskoefficienten (ratio of solubility in lipoid to solubility in water) are higher for high and low temperatures respectively. Burge, Neill and Ashman (8), from experiments with narcotics of widely different constitution, advance the theory "that narcosis is due to the direct destruction of catalase by the narcotic, with resulting decrease in oxidation, while recovery from anesthesia 1 is brought about by an increase in catalase due to the increased output from the liver, with resulting increase in oxidation." The Meyer-Overton theory of narcotics as lipoid solvents could in any case apply to the methane series alone.…”

Section: Physiology Of Nerve and Musclementioning

confidence: 99%

The physiology of nerve and muscle.

Holt¹

1920

Psychological Bulletin

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Different types of muscle and nerve cells can be excited or stimulated by many types of stimuli, and have the ability to respond to these stimuli. Physiology of the nerve The nervous system is divided into the central nervous system (CNS) which includes the brain and spinal cord, and the peripheral nervous system which includes the cranial nerves arising from the brain and the spinal nerves arising from the spinal cord. Neurons are the basic structural and functional units of the nervous system. They are specialized to respond to physical and chemical stimuli, conduct electrochemical impulses, and release chemical regulators. Most neurons cannot divide by mitosis. Neurons generally have 3 principle regions: (1) a cell body, (2) dendrites, and (3) an axon. Dendrites and axons are called processes. The cell body is the enlarged part of the neuron that contains the nucleus, Golgi complex, mitochondria, ribosomes, rough endoplasmic reticulum known as Nissl bodies. The dendrites are thin, branched processes that extend from the cytoplasm of the cell body. Dendrites provide a receptive area that transmits electrical impulses to the cell body. The axon is a longer process that conducts impulses away from the cell body. Axons vary in length. The origin of the axon near the cell body is an expanded region called the axon hillock, it is here that nerve impulses originate. It conducts impulses away from the cell body. Side branches called axon collaterals may extend from the axon. Functional classification of neurons 1-Sensory (afferent) neurons conduct impulses from sensory receptors into CNS. 2-Association neurons (interneurons) are located entirely within the CNS and serve the associative functions of the nervous system. 3-Motor (efferent) neurons conduct impulses out of the CNS to effector organs (muscles or glands). There are 2 types of motor neurons:

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Section: Physiology Of Nerve and Musclementioning

confidence: 99%