The wet grip performance of tire is one of the important performances affecting vehicle safety. The steering, acceleration, and braking of the vehicle are directly affected by the grounding characteristics between the radial tire and the ground. In order to study the influence of grounding characteristics of the tire on wet grip performance, ten 205/55R16 tires produced by different manufacturers were selected and tested. The grounding characteristics of the tires were tested using an optical test rig for tire grounding pressure distribution, considering inflation pressure distribution, load and wheel alignment. The tire-road contact area was subdivided into five parts, and 69 parameters were used to describe the grounding characteristics. A software was proposed to process the test results automatically, and 69 grounding characteristic parameters of each tire were obtained. Correlation analysis on tire wet grip performance and grounding characteristics was used for selecting the principal parameters. Finally, eight grounding characteristic parameters related to tire wet grip performance was obtained. Among them are five grounding characteristic parameters (central area rectangle ratio, central area width, internal shoulder length-to-width ratio, external and internal shoulder contact area ratio, external and internal shoulder impression area ratio) which have high correlation to tire wet grip performance, and three grounding characteristic parameters (external shoulder width, external shoulder length-to-width ratio, external and internal shoulder width ratio) which have low correlation to the wet grip performance of the tire. The principal component analysis method was used to analyze the highly correlated grounding characteristic parameters, and the regression equation for evaluating tire wet grip performance was fitted. The comparison of experimental and fitted values show that the errors are within 4%. The result demonstrates that, the method for evaluating wet grip performance of the radial tire through tire-road grounding characteristics was achieved.