The mechanisms of cytotoxicity of urethane dimethacrylate to Chinese hamster ovary cells

The cytotoxicity of methacryloxylethyl cetyl ammonium chloride, a cationic antibacterial monomer, is related to oxidative stress and the intrinsic mitochondrial apoptotic pathway

“…Recent invetigations have indicated that the disturbance of cellular redox balance is involved in dental monomer-related cytotoxicity (14)(15)(16)(17). However, to our knowledge, no report concerning the involvement of ROS overproduction in antibacterial monomer-related cytotoxicity has been published.…”

The role of reactive oxygen species and hemeoxygenase-1 expression in the cytotoxicity, cell cycle alteration and apoptosis of dental pulp cells induced by BisGMA

“…After 24-h of cell attachment, they were exposed to fresh medium comprising solvent or different concentrations of BisGMA (0.01e0.25 mM) for 24 h. Thereafter, both floating and attached cells were collected [9,21]. Cells were then stained with trypan blue and viable cells that excluded the dye were counted for estimation the cytotoxicity of BisGMA as described previously [20,22].…”

Cytotoxic effects of acrylic acid, methacrylic acid, their corresponding saturated carboxylic acids, HEMA, and hydroquinone on fibroblasts derived from human pulp

“…However, it has been pointed out that such materials occasionally cause pulp irritation [1][2][3][4][5] . Furthermore, there are many reports on the cytotoxic effects of the hydrophobic compounds included in composite resins, such as Bis-GMA and TEGDMA or their analogues [6][7][8][9][10][11][12][13][14][15][16][17][18][19] , which is also related to the problem of environmental estrogens by bisphenol A. The relationship between the three-dimensional structure of environmental estrogens and the toxicity (biological activity) has been studied 20,21) .…”