The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management

Fuad, Aalina Sakiinah Mohd; Amran, Nurul Aqilah; Nasruddin, Nurrul Shaqinah; Burhanudin, Nor Aszlitah; Dashper, Stuart; Arzmi, Mohd Hafiz

doi:10.1007/s12602-022-09985-7

Cited by 22 publications

(16 citation statements)

References 78 publications

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“…Moreover, these practices have the potential to improve treatment-related dysbiosis in other parts of the alimentary canal: the oral cavity, for example. 129 – 135 …”

Section: Discussionmentioning

confidence: 99%

Manipulating the Gut Microbiome as a Therapeutic Strategy to Mitigate Late Effects in Childhood Cancer Survivors

Rahman

Dubinsky

et al. 2023

Technol Cancer Res Treat

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Recent studies have identified causal links between altered gut microbiome, chronic inflammation, and inflammation-driven conditions such as diabetes and cardiovascular disease. Childhood cancer survivors (CCS) show late effects of therapy in the form of inflammaging-related disorders as well as microbial dysbiosis, supporting a hypothesis that the conditions are interconnected. Given the susceptibility of the gut microbiome to alteration, a number of therapeutic interventions have been investigated for the treatment of inflammatory conditions, though not within the context of cancer survivorship in children and adolescents. Here, we evaluate the potential for these interventions, which include probiotic supplementation, prebiotics/fiber-rich diet, exercise, and fecal microbiota transplantation for prevention and treatment of cancer treatment-related microbial dysbiosis in survivors. We also make recommendations to improve adherence and encourage long-term lifestyle changes for maintenance of healthy gut microbiome in CCS as a potential strategy to mitigate treatment-related late effects.

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“…Moreover, these practices have the potential to improve treatment-related dysbiosis in other parts of the alimentary canal: the oral cavity, for example. 129 – 135 …”

Section: Discussionmentioning

confidence: 99%

Manipulating the Gut Microbiome as a Therapeutic Strategy to Mitigate Late Effects in Childhood Cancer Survivors

Rahman

Dubinsky

et al. 2023

Technol Cancer Res Treat

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“…As a result, postbiotics can be presented as potential treatments for diarrhea that are free from major adverse effects. Salmonella induced inflammatory bowel disease (IBD) was demonstrated to be protected from postbiotic Lactobacillus paracasei ( B21060 ) (Mohd Fuad et al, 2022).…”

Section: The Impact Of Postbiotics In Immunomodulationmentioning

confidence: 99%

“…In the meantime, the word symbiotics were collected to elucidate the probiotics and prebiotics relationship that assists the host by promoting microbial colonization and survival in the gut (Vrese & Schrezenmeir, 2008). Additionally, a study revealed that the use of prebiotics, probiotics, and synbiotics (a combination of prebiotics and probiotics) could influence the yields of chemical messengers (hormone levels and neurotransmitters) and inflammatory components, interfering with the eating plan which leads to obesity (Mohd Fuad et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Probing the functional and therapeutic properties of postbiotics in relation to their industrial application

Asif,

Afzaal,

Shahid

et al. 2023

Food Science & Nutrition

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Functional foods are gaining significant research attention of researchers due to their health‐endorsing properties due to their bioactive components either living cells (probiotics) or nonviable cells (prebiotics). The term “postbiotic” specifies the soluble substances, such as enzymes, peptides, teichoic acids, muropeptides derived from peptidoglycans, polysaccharides, cell surface proteins, and organic acids, that are secreted by living bacteria or released after bacterial lysis. Due to various signaling molecules which may have antioxidant, immunomodulatory, antiinflammatory, antihypertensive, and antiproliferative activities, postbiotics offer great potential to be used in pharmaceutical, food, and nutraceutical industries, to promote health and ailment prevention. This recent review is a landmark of information relevant to the production of postbiotics along with salient features to use in various fields ranging from food to immunomodulation and selective and effective therapy. It also puts forward the concept that postbiotics are way more effective than probiotics in the veterinary, food as well as medical field which ultimately helps in reducing the disease burden along with human health.

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“…Numerous reports have also highlighted the use of synbiotics in human cancer treatment (Rafter et al, 2007;Fotiadis et al, 2008;Mego et al, 2013;Scott et al, 2018;Alam et al, 2022;Fuad et al, 2022), with studies conducted by Gibson and Roberfroid (2008), Beski and Al-Sardary (2015), Kvakova et al (2021) indicating that synbiotics better protected consumers from carcinogenic compounds when compared to probiotics and prebiotics used separately.…”

Section: Health-promoting Propertiesmentioning

confidence: 99%

Feed Additives of Bacterial Origin as an Immunoprotective or Immunostimulating Factor – A Review

Szuba-Trznadel

Rząsa

2023

Annals of Animal Science

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Since January 2006 when using antibiotics as growth promoters in animal feed have been banned scientists are looking for the best resolution to apply alternative substances. Extensive research into the health-promoting properties of probiotics and prebiotics has led to significant interest in the mechanisms of action of the combined administration of these feed additives as a synbiotic. Subsequent research has led to the development of new products. Among the most important health benefits of additives are, inhibiting the growth of pathogenic bacteria in the GI tract, maintenance of homeostasis, treatment of inflammatory bowel diseases, and increase in immunity. Specific immunomodulatory mechanisms of action are not well understood and the effect is not always positive, though there are no reports of adverse effects of these substances found in the literature. For this reason, research is still being conducted on their proper application. However, due to the difficulties of carrying out research on humans, evidence of the beneficial effect of these additives comes mainly from experiments on animals. The objective of the present work was to assess the effect of probiotics, prebiotics, and synbiotics, as well as new additives including postbiotics, proteobiotics, nutribiotics, and pharmabiotics, on specific immunomodulatory mechanisms of action, increase in immunity, the reduction of a broad spectrum of diseases.

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The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management

Cited by 22 publications

References 78 publications

Manipulating the Gut Microbiome as a Therapeutic Strategy to Mitigate Late Effects in Childhood Cancer Survivors

Manipulating the Gut Microbiome as a Therapeutic Strategy to Mitigate Late Effects in Childhood Cancer Survivors

Probing the functional and therapeutic properties of postbiotics in relation to their industrial application

Feed Additives of Bacterial Origin as an Immunoprotective or Immunostimulating Factor – A Review

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