The mediation of central cyclooxygenase and lipoxygenase pathways in orexin-induced cardiovascular effects

Altınbaş, Burçin; Guvenc-Bayram, Gokcen; Yalçın, Murat

doi:10.1016/j.brainres.2020.147239

“…The i.c.v. injection of OX increased MAP and HR, resulting in a cardiovascular effect similar to the effect we reported previously(Altinbas et al 2021). First,Samson et al and Shirasaka et al 1999 reported that OX -induced cardiovascular effects.…”

supporting

confidence: 88%

The Intermediation Role of Central Cyclooxygenase Products TXA2, PGF2α, PGE, and PGD in Orexin-evoked Cardiovascular Effects

Altınbaş¹,

Bayram²,

Yalçın³

2021

Preprint

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Centrally injected some prostaglandins (PG) and orexin (OX) produce similar cardiovascular responses. We have recently reported that both central cyclooxygenase (COX) and central lipoxygenase (LOX) enzymes mediate the cardiovascular effects of OX. In the current study, we aimed to investigate the mediating effects of thromboxane (TX) A2, PGD, PGE, and PGF2a, as COX pathway subproducts known to be active in cardiovascular control, on cardiovascular responses elicited by OX. Intracerebroventricular (i.c.v.) injection of OX increased cardiovascular levels in normotensive male Sprague Dawley rats. Moreover, central pretreatment with the TXA2 synthesis inhibitor furegrelate, PGF2α receptor antagonist, PGF2α-dimethylamine, PGE, and PGD receptor antagonist AH6809 partially attenuated the centrally administered OX -induced pressor and tachycardic cardiovascular responses in rats. In conclusion, our results show that i.c.v. injection of OX increases blood pressure and heart rate. Moreover, TXA2, PGF2α, PGE, and PGD mediate, at least in part, the centrally applied OX -evoked pressor and tachycardic responses. The results suggest that centrally injected OX -evoked pressor and tachycardia responses may also be mediated by arachidonic acid metabolites other than TXA2, PGF2α, PGE, and PGD.

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“…Our recent study suggested that there is an interaction between the central OX and AA cascade (Altinbas et al 2021). In this study, we showed that i.c.v.…”

Section: Discussionsupporting

confidence: 51%

“…injected normotensive rats. The dose of OX was chosen from the effective dose used in our previous study (Altinbas et al 2021).…”

Section: Experimental Protocolsmentioning

confidence: 99%

The Intermediation Role of Central Cyclooxygenase Products Txa2, Pgf2α, Pge, and PGD in Orexin-Evoked Cardiovascular Effects

Altınbaş

¹

2021

Izmir Democracy University Health Sciences Journal

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Centrally injected some prostaglandins (PG) and orexin (OX) produce similar cardiovascular responses.We have recently reported that both central cyclooxygenase (COX) and central lipoxygenase (LOX) enzymes mediate the cardiovascular effects of OX. In the current study, we aimed to investigate the mediating effects of thromboxane (TX) A 2 , PGD, PGE, and PGF 2a , as COX pathway subproducts known to be active in cardiovascular control, on cardiovascular responses elicited by OX. Intracerebroventricular (i.c.v.) injection of OX increased cardiovascular levels in normotensive male Sprague Dawley rats. Moreover, central pretreatment with the TXA 2 synthesis inhibitor furegrelate, PGF 2α receptor antagonist, PGF 2α -dimethylamine, PGE, and PGD receptor antagonist AH6809 partially attenuated the centrally administered OX -induced pressor and tachycardic cardiovascular responses in rats.In conclusion, our results show that i.c.v. injection of OX increases blood pressure and heart rate. Moreover, TXA 2 , PGF 2α , PGE, and PGD mediate, at least in part, the centrally applied OX -evoked pressor and tachycardic responses. The results suggest that centrally injected OX -evoked pressor and tachycardia responses may also be mediated by arachidonic acid metabolites other than TXA 2 , PGF 2α , PGE, and PGD. HighlightsCentral injection of OX augments MAP and HR.The TXA 2 mediates the OX-produced cardiovascular responses.The central PGF 2a intermediates the OX-produced cardiovascular responses.The central PGE and PGD are involved in the OX-produced cardiovascular responses. et al. 1999). On the other hand, previous studies in this research area have reported that the OX-evoked cardiovascular effects are mediated by the vasopressinergic (Al-Barazanji et al. 2001), renin-angiotensin (Lin et al. 2002), cholinergic (Antunes et al. 2001), and histaminergic systems (Jochem 2009.AA released from membrane phospholipids by activation of phospholipase A 2 (PLA 2 ) forms prostaglandins (PG) or leukotrienes via the COX or lipoxygenase LOX enzyme pathway (Smith et al. 2000;Wlodawer and Samuelsson 1973). In previous studies, researchers have documented that AA and its metabolites are involved in cardiovascular control (Tassoni et al. 2008). Centrally injected melittin, PLA 2 activator and AA increased arterial pressures in normotensive and hypotensive rats (Yalcin and Erturk 2007; Yalcin and Aydin 2009;). It could be considered that centrally injected melittin-or AA -induced cardiovascular responses are the result of possibly central COX pathway products. This is because it is known that as AA -COX pathway products centrally PGE 2 ,

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Salvia africana-lutea L.: a review of ethnobotany, phytochemistry, pharmacology applications and future prospects

Ezema,

Aguchem,

Aham

et al. 2023

ADV TRADIT MED (ADTM)

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Plants are nature’s reserve for vitality and health-boosting agents. Despite ever-rising interest and research on plant medicinal chemistry, many stones are still being left unturned. Moreover, many traditional medicinal plants are yet to be discovered or functionally characterized. This study presented an up-to-date review of a poorly explored member of the Salvia genus indigenous to Africa—Salvia africana-lutea L. (synonymous with Salvia aurea L.) with details on its geographical distribution, ethnobotany, and pharmacological applications. We reviewed all literature published on Salvia africana-lutea up to January 2023, retrieved from PubMed, Scopus, and ScienceDirect as primary databases and google scholar as the secondary source. From our literature search, we found 38 documents published on S. africana-lutea, despite the popularity of the Salvia genus as a medicinal plant (having over 15,000 articles published to date). From the retrieved literature, only a few studies focused on exploiting the ethnobotanical features of the plants, such as the morphology, flowering and existence, and nature of its trichomes. Some studies have reported S. africana-lutea as an excellent source of essential oils trapped within their leaf trichomes with numerous phytochemicals and bioactivities. Other studies have reported some interesting pharmacological activities of plant extracts and isolated phytochemicals, such as their antimicrobial, anti-oxidative, analgesic, antipyretic, anticancer, cytotoxic, and other bioactivities. We identified some limitations of the few published studies, highlighting future research needs that should draw more scientific interest to foster more study on this under-explored and valuable plant species of Salvia, to harness its medicinal and industrial potential fully.

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The mediation of central cyclooxygenase and lipoxygenase pathways in orexin-induced cardiovascular effects

Cited by 6 publications

References 49 publications

The Intermediation Role of Central Cyclooxygenase Products TXA2, PGF2α, PGE, and PGD in Orexin-evoked Cardiovascular Effects

The Intermediation Role of Central Cyclooxygenase Products TXA2, PGF2α, PGE, and PGD in Orexin-evoked Cardiovascular Effects

The Intermediation Role of Central Cyclooxygenase Products Txa2, Pgf2α, Pge, and PGD in Orexin-Evoked Cardiovascular Effects

Salvia africana-lutea L.: a review of ethnobotany, phytochemistry, pharmacology applications and future prospects

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