The medical complications of obesity

Malnick, Stephen; Knobler, Hilla

doi:10.1093/qjmed/hcl085

Cited by 461 publications

(345 citation statements)

References 170 publications

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“…Obesity and overweight status are associated with the risk of suffering from chronic diseases such as cardiovascular disease or atherosclerosis (1). Middle-aged and elderly population is growing up in developed countries due to the increase of life expectancy.…”

Section: Introductionmentioning

confidence: 99%

Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet

Ibero-Baraibar

Abete

Navas-Carretero

et al. 2014

Nutrition, Metabolism and Cardiovascular Diseases

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Section: Introductionmentioning

confidence: 99%

Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet

Ibero-Baraibar

Abete

Navas-Carretero

et al. 2014

Nutrition, Metabolism and Cardiovascular Diseases

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“…incidence of certain forms of cancer, respiratory complications (obstructive sleep apnea), dyslipidemia, hypertension, atherosclerosis and vascular alterations 1,5 . Current guidelines strongly endorse weight loss for patients who are overweight or obese.…”

mentioning

confidence: 99%

Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

Nascimento¹,

Baptista²,

Pereira³

et al. 2011

Arq. Bras. Cardiol.

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“…Obesity rates in humans are increasing globally (Seidell and Halberstadt 2015;Swinburn et al 2011). Obesity is associated with numerous comorbidities such as hypertension, Type 2 diabetes mellitus, and coronary heart disease (Malnick and Knobler 2006;Pi-Sunyer 2002). Many studies have used 3T3-L1 and 3T3-F422A mouse cells or primary human adipocytes to study the metabolic changes that occur in individuals suffering from obesity-related illnesses (Farmer 2006;Lefterova and Lazar 2008;Ntambi and Kim 2000).…”

Section: Introductionmentioning

confidence: 99%

A protocol for the isolation and cultivation of brown bear (Ursus arctos) adipocytes

et al. 2016

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Brown bears (Ursus arctos) exhibit hyperphagia each fall and can become obese in preparation for hibernation. They do this without displaying the physiological problems typically seen in obese humans, such as Type 2 diabetes and heart disease. The study of brown bear hibernation biology could therefore aid in the development of novel methods for combating metabolic diseases. To this end, we isolated mesenchymal stem cells from subcutaneous fat biopsies, and culture methods were developed to differentiate these into the adipogenic lineage. Biopsies were taken from 8 captive male (N = 6) and female (N = 2) brown bears, ages 2-12 years. Plastic adherent, fibroblast-like cells were proliferated and subsequently cryopreserved or differentiated. Differentiation conditions were optimized with respect to fetal bovine serum content and time spent in differentiation medium. Cultures were characterized through immunostaining, RT-qPCR, and Oil red O staining to quantify lipid accumulation. Adiponectin, leptin, and glycerol medium concentrations were also determined over the course of differentiation. The culturing protocol succeeded in generating hormone-sensitive lipase-expressing, lipid-producing white-type adipocytes (UCP1 negative). Serum concentration and time of exposure to differentiation medium were both positively related to lipid production. Cells cultured to low passage numbers retained similar lipid production and expression of lipid markers PLIN2 and FABP4. Ultimately, the protocols described here may be useful to biologists in the field investigating the health of wild bear populations and could potentially increase our understanding of metabolic disorders in humans.

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The medical complications of obesity

Cited by 461 publications

References 170 publications

Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet

Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet

Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

A protocol for the isolation and cultivation of brown bear (Ursus arctos) adipocytes

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