The medicinal plant potential parts and species diversity as antipyretic: Ethnobotany study at Senduro Lumajang

Rahardjanto, Abdulkadir; Ikhtira, Dilla Anisa; Nuryady, Moh. Mirza; Pantiwati, Yuni; Widodo, Nur; Husamah, Husamah

doi:10.1063/5.0053124

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…Pemanfaatan tumbuhan tersebut berasal dari nenek moyang terdahulu. Namun, resep obat tradisional yang diturunkan secara turun-temurun tersebut hanya sebatas pengetahuan tradisional dan belum dibuktikan secara ilmiah, sehingga efektivitas dan toksisitas tumbuhan tersebut tidak diketahui secara pasti, meskipun obat-obatan dari bahan alam umumnya dianggap aman dan efektif (Rahardjanto et al, 2020).…”

Section: Pendahuluanunclassified

EVALUASI SENYAWA BIOAKTIF Nasturtium montanum Wall. SEBAGAI KANDIDAT AGEN ANTIPIRETIK TERHADAP RESEPTOR PROSTAGLANDIN SYNTASE 2 (PTGS2) SECARA IN SILICO [Evaluation of Bioactive Compounds of Nasturtium montanum Wall. as Antipyretic Agent Candidate Toward Prostaglandin Syntase 2 (PTGS2) Through in Silico]

Ikhtira,

Rohman,

Lestari

2023

Berita Biologi

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The inhibition of prostaglandin syntase 2 ( PTGS2 route is necessary in order to prevent an feverfever. Antipyretic drugs such as the Non steroids ( NSAIDs are fever medication which acts as non-selective inhibitor of PTGS2. NSAID overdose cases have led to herbal ingredients utilization as alternative remedies, such as the Nasturtium montanum leaves. This research aimed to observe the interaction of selected bioactive compounds within N. montanum with the PTGS2 target protein through molecular docking. In addition, this research used in silico approach conducted with molecular docking method trough several stages such as preparation of 3D ligand structure and protein, protein sterilization by PyMOL, docking compounds with PyRx and visualization of docking results via LigPlot+. Results obtained from this research shows the bond dissociation energy value of 1-O-sinapoyl-beta-D-glucose, kaempferol 3-O-sophoroside, patuletin 3-gentiobioside and quercetin 3-O-malonylglucoside substances are smaller compared to meclofenamic acid causing the four ligand tests more stable in their binding to PTGS2 receptor. Meclofenamic acid and 1-O-sinapoyl-beta-D-glucose both bind to PTGS2 receptor with the same amino acid residue as well as the same interaction. Whereas meclofenamic acid, kaempferol 3-O-sophoroside, patuletin 3-gentiobioside and quercetin 3-O-malonylglucoside bind to PTGS2 receptor with the same amino acid residue yet have different bond interaction.

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Section: Pendahuluanunclassified

EVALUASI SENYAWA BIOAKTIF Nasturtium montanum Wall. SEBAGAI KANDIDAT AGEN ANTIPIRETIK TERHADAP RESEPTOR PROSTAGLANDIN SYNTASE 2 (PTGS2) SECARA IN SILICO [Evaluation of Bioactive Compounds of Nasturtium montanum Wall. as Antipyretic Agent Candidate Toward Prostaglandin Syntase 2 (PTGS2) Through in Silico]

Ikhtira,

Rohman,

Lestari

2023

Berita Biologi

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“…Indonesia is known as a biodiverse country. Plant biodiversity supports the development of traditional community culture and daily life (Rahardjanto et al 2021; Van de Vuurst and Escobar 2020; Zeng et al 2022). In particular, the leaves and petioles of sungkai (Peronema canescens Jack.)…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antioxidant activity of endophytic fungi extracts isolated from the petiole of sungkai plant (Peronema canescens)

OKTIANSYAH,

ELFITA,

WIDJAJANTI

et al. 2023

Biodiversitas

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Abstract. Oktiansyah R, Elfita, Widjajanti H, Salni, Setiawan A. 2023. Antibacterial and antioxidant activity of endophytic fungi extracts isolated from the petiole of sungkai plant (Peronema canescens). Biodiversitas 24: 6516-6526. Indonesia has a diverse number of medicinal plants that are very helpful in preventing infectious diseases. Sungkai (Peronema canescens) is a medicinal plant of the family Verbenaceae that is often used and found in Indonesia. Its leaves possessed antibacterial and antioxidant properties that boost immunity and lessen the signs of infectious disorders. This study explored the types of endophytic fungi found in sungkai petioles and examined their relationship to previously reported sungkai leaf endophytic fungal isolates and spectrum of compounds contained them. Endophytic fungal were isolated from fresh leaf petioles of host plants, and their morphological and molecular characteristics were determined. Endophytic fungal extracts were tested for antibacterial and antioxidant properties. Utilizing the paper disk diffusion technique, the antibacterial characteristics were ascertained, while the DPPH method was used to determine antioxidant activity. Molecular identification was carried out on the fungal isolate with the most potential, and chemical compounds were isolated using column chromatography. The structures of the compounds were determined using spectroscopy, including 1D and 2D NMR. Eight endophytic fungal isolates were obtained from sungkai leaf stalks (RA1-RA8) of various species of the genus Trichoderma. Differences in the diversity of endophytic fungi found in leaf stalks and endophytic fungi from leaves were identified. RA1 showed the strongest antibacterial and antioxidant activity and was molecularly identified as T. harzianum. Spectroscopic analysis showed that the pure compound contained within was 9-hydroxy-7-methylenebenzo[c]oxepin-3(7H)-one (1), which had never previously been found in sungkai plants and endophytic fungi. The antibacterial activity of Compound 1 is in the strong category (MIC = 64 µg/mL) but is not active as an antioxidant. In terms of producing medicinal ingredients from endophytic fungi, T. harzianum in extract form has more potential to be developed.

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“…As a country with immense biodiversity, Indonesia has an abundance of medicinal plants. Studies have emphasised the importance of biodiversity to human health, with one of its most apparent advantages being the pharmaceuticals derived from the natural world [19][20][21]. More than 50% of commercially available pharmaceuticals are based on plant bioactive compounds [22,23].…”

Section: Introductionmentioning

confidence: 99%

Biological potential of eight medicinal plants collected in the restored landscape after mining in South Kalimantan

Wiraswati,

Pradini,

Fauziah

et al. 2024

Discov Appl Sci

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Land restoration is expected to enhance the supply of valuable ecosystem resources such as herbaceous bushes and weeds. This study aimed to determine the primary phytochemical constituents and bioactivities of methanol extracts from eight bushes and weeds collected from a restored post-mining landscape in South Kalimantan, Indonesia. Qualitative phytochemical analysis showed the presence of phenolic compounds, flavonoids, tannins, alkaloids, steroids, terpenoids and saponins in the methanol extracts of herbaceous plants. Their antioxidant activity was measured by using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate assay. Their superoxide dismutase (SOD) activity was also measured. In addition, selected plant extracts were screened against the common human pathogens Staphylococcus aureus and Candida albicans. Phytochemical analysis showed that the methanol extracts contained all the bioactive compounds examined in this study except the one from Lycopodium cernuum, which lacked flavonoids and alkaloids. Further investigation revealed that all methanol extracts except the one from L. cernuum had promising antioxidant potential. The methanol extracts from Chromolaena odorata (stem), Trema micrantha, Melastoma malabathricum (flower and leaf) and Thypa angustifolia exhibited effective antibacterial activity. In addition, the methanol extracts from M. malabathricum (flower and leaf), T. micrantha, Scleria sumatrensis and Breynia cernua (leaf) exhibited effective antifungal activity. M. malabathricum (flower and leaf) has the greatest potential as a herbaceous plant since its methanol extract exhibits the most potent antioxidant, antibacterial and antifungal activities.

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The medicinal plant potential parts and species diversity as antipyretic: Ethnobotany study at Senduro Lumajang

Cited by 8 publications

References 14 publications

Antibacterial and antioxidant activity of endophytic fungi extracts isolated from the petiole of sungkai plant (Peronema canescens)

Biological potential of eight medicinal plants collected in the restored landscape after mining in South Kalimantan

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