The medicinal properties of Cassia fistula L: A review

Mwangi, R. W.; Macharia, John M.; Wagara, I. N.; Raposa, László Bence

doi:10.1016/j.biopha.2021.112240

Cited by 53 publications

(29 citation statements)

References 47 publications

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“…Cassia fistula is ethnomedicinally used to treat anorexia, dermal contaminations, jaundice, ulcers, and inflammatory circumstances like rheumatism [7]. It is also used as anthelmintic, purgative, carminative, antipyretic, expectorant, analgesic, laxative, antiseptic, bronchitis, and antidote against snake poison [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Stem bark of Cassia fistula contains β-sitosterol, fistucacidin (3, 4, 7, 8, 4′-pentahydroxyflavon), leucocyanidin, lupeol, oxyanthraquinone, dihydroxyanthraquinone, and flavonol glycosides (Figure 1), and hexacosanol [12][13][14]. In numerous in vitro and in vivo experiments, these phytocompounds have exhibited considerable pharmacological activities including antioxidant, anti-inflammatory [15], antimicrobial [16], antiviral, anticancer [17], hepatoprotective [18], antidiabetic [19], hypolipidemic, antileishmaniatic [20], antipyretic, purgative, and wound healing potential in preclinical studies [9]. e plant genus Cassia has been indexed as an important constituent of various traditional herbal medicines due to its strong cardioprotective and antioxidant potentials.…”

Section: Introductionmentioning

confidence: 99%

“…Tree, namely, bark, heartwood, flowers, leaves, and seed kernels are attributed with medicinal properties. The high medicinal prominence of Cassia fistula is due to the presence of many bioactive phytocomponents particularly anthraquinone glycosides, lignans, flavonoids, alkaloids, tannins, resins, sesquiterpenes, and fatty acids [ 9 ]. Stem bark of Cassia fistula contains β -sitosterol, fistucacidin (3, 4, 7, 8, 4′-pentahydroxyflavon), leucocyanidin, lupeol, oxyanthraquinone, dihydroxyanthraquinone, and flavonol glycosides ( Figure 1 ), and hexacosanol [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Activity of Cassia fistula L. Bark Extract in Isoproterenol-Induced Myocardial Infarction Rat Model

Kushwah¹,

Mittal²,

Kumar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cassia fistula Linn, generally recognized as Indian laburnum, is one of the ancient trees in the Indian subcontinent used for its ornamental and diverse medicinal properties. It is known for its ethnic medicinal uses in inflammatory and infectious pathologies such as antihelmintic, purgative, carminative, antipyretic, expectorant, analgesic, laxative, antiseptic, and antidote against snake poison. The Cassia bark is rich in anthraquinones, flavanols glycosides, and sitosterols, which renders it cardioprotective properties. The existing experiments were designed to assess the potential of Cassia fistula bark against isoproterenol (ISP)-induced cardiotoxicity in rats, which has not been validated yet. The bark was successively extracted with five different solvents, and each extract was subjected to in vitro antioxidant studies. Further acute oral toxicity assays were carried out preceding in vivo myocardial studies. Cardiotoxicity-inducing agent, ISP, was administrated to the rats for two consecutive days (8th and 9th). Based on in vitro studies, the Cassia fistula methanolic extract (CFME) was administered in two doses: CFME-LD (lower dose 250 mg/kg) and CFME-HD (high dose 500 mg/kg) separately. It was found that CFME produced a substantial decrease in lipid peroxidation and an increase in antioxidants in myocardial tissues. CFME abrogated the levels of triglyceride and total cholesterol with a decrease in alanine transaminase (ALT) and aspartate transaminase (AST) activity in serum at both doses. 2,3,5-Triphenyltetrazolium chloride (TTC) staining and histopathology also revealed the protective effects of CFME against ISP-induced myocardial infarction. The study showed the significant role of the CFME as a strong antioxidant and cardioprotective action in ISP-induced toxicity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Activity of Cassia fistula L. Bark Extract in Isoproterenol-Induced Myocardial Infarction Rat Model

Kushwah¹,

Mittal²,

Kumar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Suas sementes são usadas para distúrbios intestinais e doenças dermatológicas, IST-Infecção Sexualmente Transmissível (sífilis), hanseníase e doenças pulmonares (Mwangi, et al, 2021) antifúngicas e antibacteriana (Brigida et al, 2015). Seus metabolitos secundários presentes incluem saponinas, flavonoides, triterpeno, quercetina, cineol, alcanfor, farnesol, sais minerais entre diversos outros já estudados (Bylka et al, 2014).…”

Section: Extrato Alcoólicounclassified

Doença de alzheimer: atividade anticolinesterásica das plantas alimentícias não convencionais (PANC) uma revisão integrativa narrativa

Fernandes

Leite

Flores

et al. 2022

RSD

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Objetivo: Realizar uma revisão integrativa narrativa sobre plantas alimentícias não convencionais (PANC), que apresentam ação inibitória da enzima acetilcolinesterase, utilizando para isso as bases de dados mais consultadas na atualidade; Alencar os metabolitos identificados nas espécies alimentícias não convencionais com aplicação anticolinesterasica. Métodos: Levantamento de artigos que abordaram estudos de plantas nas bases de dados PubMed, Scielo, Tandfoline, Springer link, Scopus, ScienceDirect, e demais sites de busca acadêmica sem restrição de idioma e ano, utilizando os descritores e DeCS (Descritores em Ciências da Saúde). Resultados: Foram identificados 128 estudos, dos quais 22 foram selecionados para esta revisão. Conclusão: O caminho a ser percorrido é longo, até agora não sabemos em que momento um novo fármaco chegara para auxiliar no tratamento dessa doença, nesse meio tempo várias pesquisas surgem com proposito no tratamento, acessível da Doença de Alzheimer e essa pesquisa servira como base para futuros autores na busca de marcadores químicos para tratamento da Alzheimer e plantas alimenticias.

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“…Cassia fistula has been broadly recommended in conventional medicine in India. Almost all parts of Cassia fistula are accounted for anti-inflammatory, antitussive, antimicrobial, anticancerous, hepatoprotective, antioxidant, and antibacterial activity 9 .…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Cassia Fistula Bark Hexane Extract on Serum Insulin and Glucose Levels in Diabetic Rats

Zahid¹,

Saleem²,

Farooq³

et al. 2022

PJMHS

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Background: Cassia fistula (amaltas) is commonly found in Pakistan and is frequently used in medicines. Its leaves, bark and pods are conventionally used for the treatment of skin disorders, bacterial infection, constipation, colic, cirrhosis, urinary disorders, dysentery, leprosy, rheumatic conditions, jaundice, syphilis, heart diseases and diabetes mellitus (DM). Aim: To determine and compare the outcomes of cassia fistula bark (hexane extract) on serum insulin and blood glucose measures in high-fat diet-fed (HFD) and Streptozotocin-induced type 2 diabetic albino male rats.” Study design: Randomized control trial. Duration and setting: Services Institute of Medical Sciences (SIMS), Lahore from August 2016 to January 2017. Methods: The research was carried out on ninety male albino rats. Rats were induced with diabetes by giving high fat diet for 2 weeks and on fourteenth day, single injection of low dose streptozotocin (25mg/kg). The rats were categorized randomly into two groups, randomly, of 45 animals each. Group 1 was diabetic control (n=45) and group 2 was diabetic experimental and was given hexane extract of Cassia fistula bark (0.45g/kg) in 1ml of 0.3 % Carboximethyl cellulose solution by using intra gastric tube for once in a day for a month. On 31st day, 4-5 ml intra cardiac blood sample was collected. Biochemical parameters serum glucose and insulin were evaluated. Results: The diabetic rats treated with hexane extract of cassia fistula bark, exhibited significant (p=0.05) decrease in serum insulin and glucose levels. Conclusion: Hexane extract of cassia fistula bark possesses potent hypoglycemic effects. Keywords: Cassia fistula, Hypoglycemic effects, diabetic rat

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The medicinal properties of Cassia fistula L: A review

Cited by 53 publications

References 47 publications

Cardioprotective Activity of Cassia fistula L. Bark Extract in Isoproterenol-Induced Myocardial Infarction Rat Model

Cardioprotective Activity of Cassia fistula L. Bark Extract in Isoproterenol-Induced Myocardial Infarction Rat Model

Doença de alzheimer: atividade anticolinesterásica das plantas alimentícias não convencionais (PANC) uma revisão integrativa narrativa

Outcomes of Cassia Fistula Bark Hexane Extract on Serum Insulin and Glucose Levels in Diabetic Rats

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