The melatonin contained in beer can provide health benefits, due to its antioxidant, anti‐inflammatory and immunomodulatory properties

Maldonado, Mónica; Romero-Aibar, J.; Calvo, Juan R.

doi:10.1002/jsfa.12179

Cited by 13 publications

(8 citation statements)

References 116 publications

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“…Another important drug from the perspective of inflammation therapy in AD is N-acetyl-5-methoxytryptamine, otherwise known as melatonin. It exhibits properties that model the activity of inflammatory pathways [ 217 , 218 ]. Melatonin inhibits pro-inflammatory processes by slowing down the release of NO nitric oxide, activating cyclooxygenase-2 and the formation of the NLR-P3 inflammosome, which is the structure of cytosolic oligomers and is induced to activate the inflammatory response.…”

Section: Treatment Of Inflammation In Admentioning

confidence: 99%

Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review

Twarowski

Herbet

2023

IJMS

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Alzheimer’s disease is one of the most commonly diagnosed cases of senile dementia in the world. It is an incurable process, most often leading to death. This disease is multifactorial, and one factor of this is inflammation. Numerous mediators secreted by inflammatory cells can cause neuronal degeneration. Neuritis may coexist with other mechanisms of Alzheimer’s disease, contributing to disease progression, and may also directly underlie AD. Although much has been established about the inflammatory processes in the pathogenesis of AD, many aspects remain unexplained. The work is devoted in particular to the pathomechanism of inflammation and its role in diagnosis and treatment. An in-depth and detailed understanding of the pathomechanism of neuroinflammation in Alzheimer’s disease may help in the development of diagnostic methods for early diagnosis and may contribute to the development of new therapeutic strategies for the disease.

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Section: Treatment Of Inflammation In Admentioning

confidence: 99%

Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review

Twarowski

Herbet

2023

IJMS

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“…In addition, we discovered that the association between DII and anemia risk was not significant, which may be due to the anti-inflammatory effects of moderate alcohol consumption. [ 48 ] This also explains why participants with a drinking history were excluded, but participants with a smoking history were included in a cross-sectional study that investigated the correlation between DII and RA. [ 49 ] In addition, they considered that drinking alcohol might alter the nutritional status of patients.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of anemia in patients with rheumatoid arthritis and its association with dietary inflammatory index: A population-based study from NHANES 1999 to 2018

Song,

Zhang,

et al. 2024

Medicine

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Anemia is common in patients with rheumatoid arthritis (RA), and it is unknown whether the dietary inflammatory index (DII) is linked to anemia. This study aimed to clarify the prevalence of anemia in RA patients and its association with the DII. The data utilized in this study were collected from the National Health and Nutrition Examination Survey database from 1999 to 2018. The prevalence of anemia in RA patients was estimated by ethnicity, sex, and age. Weighted multivariate logistic regression was utilized to explore the correlation between anemia risk and DII. The most crucial dietary factors related to the risk of anemia in RA patients were screened by stepwise regression. A nomogram model was established according to key dietary factors. A total of 10.25% (confidence interval, 8.58–11.92%) of RA patients will develop anemia, with the lowest prevalence around the age of 60. In addition, higher DII levels were discovered in anemic patients than in nonanemic patients. In multivariate regression models, an important positive association was revealed between anemia and growing quartiles of DII (Q4 vs Q1: odds ratio = 1.98; confidence interval, 1.25–3.15). In the subgroup analysis, the adjusted relation of DII with anemia in females, Mexicans, smokers, nondrinkers, and age groups ≥ 60 years was statistically significant. The same association was observed in the sensitivity analysis. A nomogram model based on stepwise regression screening of key dietary factors showed good discriminatory power to identify anemic risk in RA patients (area under the curve: 0.707). In patients with RA, high DII levels were associated with the risk of anemia. More attention should be given to controlling dietary inflammation to better prevent and treat anemia.

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“…Melatonin has been recognized for its natural hormone secretion by the pineal gland [ 10 ]. Furthermore, it has been found to possess significant anti-inflammatory properties [ 11 ] and has been utilized as a means to reduce blood loss during surgical procedures, particularly during cesarean delivery [ 3 ]. “Postpartum hemorrhage” (PPH) refers to excessive bleeding following childbirth, typically defined as blood loss of 1000 mL or more after a cesarean delivery [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Alkhfaji,

Kahloul,

Askar

et al. 2023

Anesthesiology Research and Practice

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Background. Postpartum hemorrhage (PPH) is a serious postdelivery condition with a high incidence of morbidity and mortality for women who undergo childbirth with or without a caesarean section. Melatonin has been suggested to increase the contractility of myometrium and reduce the pain score postoperatively, therefore it is believed that the use of melatonin before surgery may decrease blood loss, reduce pain score, and decrease the need for postoperative opioids. Objectives. The main objectives of this study are focused on the investigation of melatonin as a premedication agent to reduce blood loss and decrease pain score postoperatively in patients undergoing cesarean section under spinal anesthesia. Methods. 80 patients were scheduled for spinal anesthesia-based cesarean sections and randomly assigned to two groups, melatonin group (M) 40 patients and placebo group (P) 40 patients to receive either 10 mg of sublingual melatonin or a placebo of 90 minutes preoperatively. Hemoglobin levels were been measured preoperative and 12 hrs. Postoperatively, blood loss volume was calculated by measuring both the weight of used materials before and after the surgery and the volume sucked in the suction bottle after placental delivery. Postoperative visual pain score and analgesic requirements were used to evaluate pain levels. Results. Analyzed collected data showed a significant decrease in blood loss in the melatonin group in comparison with the placebo group as measured by the hemoglobin level. On the other hand, there is a significant decrease in pain score and analgesia requirement with the melatonin group compared to the placebo group. Conclusion. Melatonin is a promising premedication drug that has a significant impact on postpartum hemorrhage by reducing blood loss and pain levels of mothers who have undergone C-sections.

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The melatonin contained in beer can provide health benefits, due to its antioxidant, anti‐inflammatory and immunomodulatory properties

Cited by 13 publications

References 116 publications

Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review

Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review

Prevalence of anemia in patients with rheumatoid arthritis and its association with dietary inflammatory index: A population-based study from NHANES 1999 to 2018

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

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