The metabolic consequences of sleep deprivation

Knutson, Kristen L.; Spiegel, Karine; Penev, Plamen D.; Cauter, Eve Van

doi:10.1016/j.smrv.2007.01.002

Cited by 1,112 publications

(877 citation statements)

References 102 publications

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“…The finding that genetic variation within the MTNR1B gene region affects glucose levels and risk of type 2 diabetes is not surprising, given that melatonin has an inhibitory effect on insulin release and that MTNR1B is transcribed in human pancreatic islets [3,9]. Furthermore, sleep disturbances and altered circadian rhythm have previously been linked to metabolic dysfunction, including type 2 diabetes [7,8]. These recent studies have provided additional knowledge regarding the mechanisms by which the melatonin system contributes to this pathogenic process [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…As a highly lipophilic circulating hormone, melatonin easily reaches and penetrates all cells and, in addition to controlling circadian rhythm, it has the ability to neutralise reactive oxygen and nitrogen species and activate the immune system [6]. Several studies have shown a link between disturbances of circadian rhythm and metabolic diseases, including diabetes [7,8], as well as a clear relationship between insulin and melatonin [9]. Two distinct G proteincoupled receptors, MTNR1A and MTNR1B, mediate the effects of melatonin.…”

Section: Introductionmentioning

confidence: 99%

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A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

et al. 2009

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Aims/hypothesis Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in populations of European ancestry. In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect. Methods The MTNR1B variant rs10830963 was genotyped in 1,165 type 2 diabetic patients and 1,105 normoglycaemic control individuals of southern Han Chinese ancestry who were residents of the metropolitan area of Shanghai. The risk of developing type 2 diabetes was calculated using a logistic regression model adjusted for age, sex and BMI. A possible association with fasting plasma glucose was analysed in the normoglycaemic control individuals using a multiple linear regression analysis with adjustments for age, sex and BMI. Results The genetic variant rs10830963 was associated with an increased risk of type 2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p=0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p=4×10 −5 ) per risk allele. Conclusions/interpretation A common variant in the MTNR1B gene is associated with an increased risk of type 2 diabetes and increased fasting plasma glucose in Han Chinese, suggesting an important role for this polymorphism in populations of different ethnic and environmental backgrounds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

et al. 2009

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“…The mechanisms underlying the association between short or long sleep duration and cancer risk are not fully understood. Two potential biological mechanisms have been proposed to explain how short sleep duration directly influenced cancer incidence, including impaired immune function and metabolic pathways related to obesity (Knutson et al, 2007;Marshall et al, 2008). Moreover, the altered melatonin secretion has also been shown as a potential risk factor of cancer (Stevens et al, 2007;Benke et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Sleep Duration and Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies

Zhao¹,

Yin²,

Yang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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To assess the risk of cancers associated with sleep duration using meta-analysis of published cohort studies, we performed a comprehensive search using PubMed, Embase and Web of Science through October 2013. We combined hazard ratios (HRs) from individual studies using meta-analysis approaches. A random effect dose-response analysis was used to evaluate the relationship between sleep duration and cancer risk. Subgroup analyses and sensitivity analyses were also performed. Publication bias was evaluated using Funnel plots and Begg's test. A total of 13 cohorts from 12 studies were included in this meta-analysis, which included 723, 337 participants with 15, 156 reported cancer outcomes during a follow-up period ranging from 7.5 to 22 years. The pooled adjusted HRs were 1.06 (95% CI: 0.92, 1.23; P for heterogeneity =0.003) for short sleep duration, 0.91 (95% CI: 0.78, 1.07; P for heterogeneity <0.0001) for long sleep duration. In subgroup analyses stratified by cancer type, long duration of sleep showed an inverse relation with hormone-related cancer (HR=0.79; 95% CI: 0.65, 0.97; P for heterogeneity =0.009) and a greater risk of colorectal cancer (HR=1.29; 95% CI: 1.09, 1.52; P for heterogeneity =0.346). Further meta-analysis on dose-response relationships showed that the relative risks of cancer were 1.00 (95% CI: 0.99, 1.01; P for linear trend=0.9151) for one hour of sleep increment per day, and 1.00 (95% CI: 0.98, 1.01; P for linear trend=0.7749) for one hour of sleep increment per night. No significant dose-response relationship between sleep duration and cancer was found on non-linearity testing (P=0.5053). Our meta-analysis suggests a positive association between long sleep duration and colorectal cancer, and an inverse association with incidence of hormone related cancers like those in the breast. Studies with larger sample size, longer follow-up times, more cancer types and detailed measure of sleep duration are warranted to confirm these results.

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“…Estudos experimentais têm demonstrado que a privação parcial do sono pode levar a alterações hormonais, as quais podem retornar a um nível mais normal e funcional após um período de recuperação de sono 21 . Outra forma de compensação das horas de sono perdidas pode ser a sesta.…”

Section: Discussionunclassified

Fatores associados à qualidade do sono em estudantes de Fisioterapia

et al. 2012

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RESUMO | A privação de sono é uma situação comum entre os estudantes e pode causar problemas de saúde e de aprendizagem. Dessa forma, o objetivo deste estudo foi analisar o padrão de sono de estudantes universitários do curso de fisioterapia e os fatores associados à qualidade de sono. Participaram do estudo 199 alunos do curso de Fisioterapia. Para avaliação da qualidade do sono, foi utilizado o Índice de Qualidade do Sono de Pittsburgh. Variáveis ambientais, biológicas e sociais foram obtidas e sua relação com qualidade de sono foi analisada. Pode-se observar que 51,75% dos estudantes apresentaram qualidade do sono ruim, a qual estava associada com a menor duração do sono (p<0,01) e hora de acordar mais cedo em dias de semana (p<0,01), dois turnos de trabalho (p<0,01) e maior sonolência diurna (p<0,01). Concluiu-se que 51,75% dos estudantes universitários avaliados apresentaram qualidade de sono ruim e essa pode ter causa multifatorial.Descritores | privação do sono; estudantes; fatores de risco.ABSTRACT | Sleep deprivation is a common situation among students and can cause health problems and learning difficulties. On this way, the aim of the study was to analyze the sleep pattern of physical therapy university students, as well as the associated factors with quality of sleep. A total of 199 physical therapy students participate of the study. To asses sleep quality, the Pittsburgh Sleep Quality Index was used. Environmental, biological and social variables were investigated and their relations to sleep quality were analyzed. It was shown that 51.75% of the students showed poor sleep quality, which has been associated with shorter sleep duration (p<0.01) and earlier wake-up time in weekdays (p<0.01), double work shift (p<0.01) and increased daytime sleepiness (p<0.01). It was concluded that the quality of sleep was poor in 51.75% of the evaluated students and this may have multifactorial cause.

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The metabolic consequences of sleep deprivation

Cited by 1,112 publications

References 102 publications

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

Sleep Duration and Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies

Fatores associados à qualidade do sono em estudantes de Fisioterapia

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