The metabolism and excretion of Δ9-tetrahydrocannabinol in the rat

Klausner, Howard; Dingell, James V.

doi:10.1016/0024-3205(71)90245-1

Cited by 99 publications

(20 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sensitization may also be the result of the accumulation of THC in the brain. Due to the long half-life of THC [35], increased levels of THC or its metabolites may be present by the third day of dosing in this study (PND 38), leading to increased effects on locomotor activity.…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to difficulties in measuring robust withdrawal symptoms in a spontaneous withdrawal model [32;33;34], in part because of the long half-life of cannabinoids [35;36;37]. While hyperlocomotion and paw tremors have been identified as two somatic signs of precipitated withdrawal from THC [27; 30], humans do not typically undergo precipitated withdrawal.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Withdrawal from THC during adolescence: Sex differences in locomotor activity and anxiety

Harte‐Hargrove

Dow-Edwards

2012

Behavioural Brain Research

View full text Add to dashboard Cite

Research suggests that the use and abuse of marijuana can be especially harmful if it occurs during adolescence, a period of vast developmental changes throughout the brain. Due to the localization of cannabinoid receptors within the limbic system and the established effects of cannabinoids on emotional states and anxiety levels of rats and humans, we studied the sex- and dose-related effects of Δ9-tetrahydrocannabinol (THC, the main psychoactive component in marijuana) on behavior and anxiety during spontaneous withdrawal. Male and female Sprague Dawley rats were administered 2, 7.5 or 15 mg/kg THC or vehicle from postnatal day 35–41 (approximating mid-adolescence in humans). Locomotor activity and anxiety-related behaviors were measured during drug administration and abstinence. THC caused significant dose-dependent locomotor depression during drug administration. Locomotor depression initially abated upon drug cessation, but re-emerged by the end of the abstinence period and was greater in female than male rats. We found sensitization to the locomotor-depressing effects of THC in middle- and high-dose rats and the subsequent development of tolerance in high-dose rats. The high dose of THC increased anxiety-like behaviors while the low dose decreased anxiety-like behaviors during drug administration, with females more sensitive to the anxiogenic effects of THC than males. During abstinence, females were again especially sensitive to the anxiogenic effects of THC. This study demonstrates sexually-dimorphic effects of THC on anxiety-related behaviors and locomotor activity during and after THC administration during adolescence. This information may be useful in the development of therapeutic approaches for the treatment of marijuana withdrawal in adolescents.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Withdrawal from THC during adolescence: Sex differences in locomotor activity and anxiety

Harte‐Hargrove

Dow-Edwards

2012

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…In the light of this interest in studying CBD and THC in a variety of rat models, it is essential to develop and validate analytical methods capable of monitoring the levels of CBD and THC in rat plasma to support pharmacokinetic studies. Early assays used the unspecific radioactivity-based methods [29][30][31][32]. Subsequently, liquid chromatography-mass spectrometry (LC-MS)-based assays were developed and validated for the detection of THC [33] and tandem mass spectrometry assays (LC-MS/MS) for CBD [34] in rat plasma.…”

Section: Introductionmentioning

confidence: 99%

Development of a simple and sensitive HPLC–UV method for the simultaneous determination of cannabidiol and Δ9-tetrahydrocannabinol in rat plasma

Zgair

Wong

Sabri

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

“…The rather complete metabo lism of THC in man has been abundantly shown to occur in rabbits and rats [6,7]. A number of metabolites of both A9-and A8-ThHC have been identified, particularly the 11-hydroxy and 7-hydroxy metabolites of the respective isomers of THC [8,10].…”

Section: Discussionmentioning

confidence: 99%

Cannabinoids in the Urine of Man After Single and Subchronic Oral Doses of Marihuana

Sl¹,

Le²,

Moore³

et al. 1972

Int Pharmacopsychiatry

View full text Add to dashboard Cite

The metabolism and excretion of Δ9-tetrahydrocannabinol in the rat

Cited by 99 publications

References 11 publications

Withdrawal from THC during adolescence: Sex differences in locomotor activity and anxiety

Withdrawal from THC during adolescence: Sex differences in locomotor activity and anxiety

Development of a simple and sensitive HPLC–UV method for the simultaneous determination of cannabidiol and Δ9-tetrahydrocannabinol in rat plasma

Cannabinoids in the Urine of Man After Single and Subchronic Oral Doses of Marihuana

Contact Info

Product

Resources

About