The metabolism of estrone-14C in a pregnant chimpanzee

Jirku, Helmut; Layne, Donald S.

doi:10.1016/0039-128x(65)90130-3

Cited by 24 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results have been observed (224) following injection of a tracer dose of estrone-16-C14 into a pregnant chimpanzee. It has been suggested (45,374,376) that during human pregnancy considerable quantities of estriol may be produced by the fetoplacental unit, through a biosynthetic pathway which may be at least partly independent of estrone and estradiol metabolism.…”

Section: Biosynthetic Pathwayssupporting

confidence: 85%

Steroidal estrogens

Morand¹,

Lyall²

1968

Chem. Rev.

View full text Add to dashboard Cite

Section: Biosynthetic Pathwayssupporting

confidence: 85%

Steroidal estrogens

Morand¹,

Lyall²

1968

Chem. Rev.

View full text Add to dashboard Cite

“…The glucoside formation in the rabbit is relatively low in comparison to glucuronide formation under similar conditions, in contrast to the present results with the chimpanzee ( Table 1). It is interesting that Jirku and Layne (9) reported the presence in chimpanzee urine of significant amounts of a conjugate of injected [4-14CCgestrone which was hydrolyzed by almond emulsin and not by P-glucuronidase, and which had solvent partition characteristics which suggested that it might be a non-acidic rnonog%ycsside. The present results emphasize the considerable differences which exist among mammalian species in their ability to transfer glucose to steroids.…”

Section: Resultsmentioning

confidence: 96%

The Transfer of Glucose to Steroids by Chimpanzee Liver Microsomes

Labow¹,

Williamson²,

Layne³

et al. 1975

Can. J. Biochem.

View full text Add to dashboard Cite

Microsomal preparations from chimpanzee liver can transfer glucose from UDPglucose to the 17alpha-hydroxyl group of 17alpha-estradiol and of 17alpha-estradiol-3-glucuronide. A phenolic glucoside of estrone, but not of either 17alpha- or 17beta-estradiol is also formed. No formation of glucosides of p-nitrophenol, or of diethylstilbestrol was demonstrated. The specificity of glucosyl transfer in the chimpanzee is not identical to that in either the human, the rabbit, or the sheep.

show abstract

“…It is evident that 16-hydroxylation is as prominent in the steroid metabolism of the newborn chimpanzee as in that of the newborn human. Humans, gorillas [ 11 ] and chimpanzees [ 12] all excrete oestriol as the predominant oestrogen during pregnancy. In contrast, oestriol is not as important a urinary steroid in Rhesus monkeys [ 13] and no 16-hydroxylated steroids have been isolated from foetal tissues following injection of radioactive progesterone into the foeto-placental unit of such monkeys [14].…”

Section: Resultsmentioning

confidence: 99%