The metabolism of homoanisic acid in man and guinea pigs

Oakley, Simon; Seakins, J. W. T.

doi:10.1042/bj1210017pb

Cited by 4 publications

(1 citation statement)

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“…For many years it appeared that con jugation with glutamine was peculiar to man and to phenylacetic acid since several other species including the rhesus monkey (Sherwin 1917) were shown to form phenaceturic acid. However, Power (1936) reported that the chimpanzee, like man, also formed phenacetylglutamine and later, glutamine conjugates of 3,4-dihydroxy-5-methoxyphenylacetic acid as a metabolite of mescaline (Harley-Mason & Laird 1959) and homoanisic acid (4-methoxyphenylacetic acid) and its metabolite, 4-hydroxyphenylacetic acid (Oakley & Seakins 1971), were found to be formed in man. Four species of African monkeys were briefly reported by Patel & Crawford (1963) to form a glutamine conjugate with indoleacetic acid, although such a conjugate was not formed in the ring-tailed lemur or bushbaby.…”

Section: Introductionmentioning

confidence: 99%

The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species

James

Smith

Williams

et al. 1972

Proc. R. Soc. Lond. B.

143

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14 C-Labelled phenylacetic acid has been administered to man, 14 species of sub-human primates and 11 non-primate species and their urine examined for metabolites. Four amino acid conjugates of this acid have been found in various species, namely, phenacetylglutamine, phenacetylglycine, phenacetyltaurine and diphenacetylornithine, but their occurrence varies with species. In the primates the occurrence of the glutamine and glycine conjugates appears to be correlated with their evolutionary status. Man excretes exclusively the glutamine conjugate, the Old World monkeys the glutamine conjugate and very small amounts of the glycine conjugate, the New World monkeys the glutamine conjugate and significant amounts of the glycine conjugate and the prosimians the glycine conjugate only. The non-primate mammalian species excrete the glycine conjugate and no glutamine conjugate. The two avian species examined also differed, since the pigeon excreted the glycine conjugate, whereas the domestic hen excreted mainly the ornithine conjugate with small amounts of the glycine conjugate. The conjugation of phenylacetic acid with taurine is reported for the first time. It occurs in all the species examined except the vampire bat and domestic hen, but its quantitative occurrence is haphazard amongst the species examined. It was found in significant amounts in the pigeon, ferret, bushbaby, capuchin monkey, squirrel monkey, mona monkey and baboon, but in minor amounts in other species.

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Section: Introductionmentioning

confidence: 99%