“…Metabolites represent end products of biochemical pathways; hence, they are downstream to other -omics data and therefore closest to the phenotype. Hence, metabolomics is widely recognized now as an important stepping stone to relate genotype to phenotype (Fiehn, 2002;Patti et al, 2012;Bhattacharyya et al, 2016;Johnson et al, 2016;Bhattacharyya et al, 2018;Handakumbura et al, 2019;Rodrigues & Shakhnovich, 2019;Harrison et al, 2020). In the recent past, high-throughput studies have been dedicated to understanding how genetic variations lead to changes in metabolic profile of the cell (Mulleder et al, 2016;Fuhrer et al, 2017).…”