The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity

Bakr, Riham O.; Tawfike, Ahmed; El-gizawy, Heba Abd-Elhady; Tawfik, Nashwa; Abdelmohsen, Usama Ramadan; Abdelwahab, Miada F.; Alshareef, Walaa A.; Fayez, Sahar M.; El-Mancy, Shereen S.; El-Fishawy, Ahlam M.; Abdelkawy, Mostafa A.; Fayed, Marwa A. A.

doi:10.1039/d0ra09334c

Cited by 9 publications

(2 citation statements)

References 79 publications

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“…Fakat Bakr ve ark. (2021) daha yakın tarihteki çalışmalarında M. longifolia'nın %70 etanol ekstresinin H. pylori üzerinde antimikrobiyal aktiviteye sahip olmadığını belirlemiştir [22]. Gul ve ark.…”

Section: Sonuç Ve Tartişmaunclassified

Bazi Düzce Halk İlaçlarinin Ki̇motri̇psi̇n, Üreaz İnhi̇be Edi̇ci̇ Ve Anti̇oksi̇dan Akti̇vi̇teleri̇

Günbatan

Miser-Salihoglu²,

Gürbüz³

et al. 2023

Ankara Ecz. Fak. Derg.

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Amaç: Bu araştırmada Düzce'de halk ilacı olarak kullanılan yedi bitkinin [Dioscorea communis (L.) Caddick & Wilkin, Mentha longifolia (L.) L. subsp. typhoides (Briq.) Harley, Origanum vulgare L., Rubus ulmifolius Schott, Salvia tomentosa Mill., Thymus longicaulis C.Presl subsp. longicaulis, Trachystemon orientalis (L.) D. Don] üreaz, kimotripsin inhibe edici ve antioksidan aktivitelerinin tespiti amaçlanmıştır. Gereç ve Yöntem: Bu amaçla bitkilerden metanol ve su ekstreleri hazırlanmıştır. Daha sonra in vitro üreaz ve kimotripsin inhibitör aktiviteleri belirlenmiştir. Ayrıca farklı yöntemlerle antioksidan aktiviteleri (ABTS, CUPRAC, DPPH), toplam fenol ve flavonoit içerikleri de tespit edilmiştir. Sonuç ve Tartışma: D. communis, O. vulgare, S. tomentosa ve T. longicaulis'in metanol ekstreleri orta düzeyde üreaz inhibitör aktivite (%34.26 ile %44.94 aralığında inhibisyon) gösterirken, diğerlerinde aktivite daha düşük bulunmuştur. En güçlü kimotripsin inhibe edici aktivite R. ulmifolius metanol ekstresi ve T. orientalis su ekstresinde gözlenmiştir (IC50 değerleri sırasıyla 65.32 ve 78.65µg/ml). Genel olarak, çalışılan bitkiler yüksek fenol ve flavonoit içeriklerine uygun olarak yüksek antioksidan aktivite göstermiştir. Sonuç olarak R. ulmifolius ve T. orientalis kuvvetli kimotripsin inhibe edici aktiviteleri ile dikkat çekmiştir. Bu bitkilerin kimotripsin aktivitesi üzerinde daha kapsamlı çalışmaların yapılması gerekmektedir.

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Section: Sonuç Ve Tartişmaunclassified

Bazi Düzce Halk İlaçlarinin Ki̇motri̇psi̇n, Üreaz İnhi̇be Edi̇ci̇ Ve Anti̇oksi̇dan Akti̇vi̇teleri̇

Günbatan

Miser-Salihoglu²,

Gürbüz³

et al. 2023

Ankara Ecz. Fak. Derg.

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“…Metabolomics is a valuable analytical tool used in the comprehensive, highly accurate determination of metabolites in a given metabolome [3][4][5]. This valuable technique allows the rapid identi cation (dereplication) and quanti cation of secondary metabolites in crude unfractionated extracts [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Anti-Trypanosomal Potential of The Red Sea Soft Coral Nephthea Mollis Supported by Metabolomic Profiling and Molecular Docking Studies

Allam

Mostafa

Abdelmohsen

et al. 2021

Preprint

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The total ethanol extract and its derived ethyl acetate fraction of the soft coral Nephthea mollis displayed remarkable in-vitro anti-trypanosomal potential against Trypanosoma brucei with IC50 value of 6.4 and 3.7 (µg/ml, 72 h respectively. Consequently, the total ethanol extract was subjected to LC-HR-ESI-MS metabolomic profiling to discover the constituents that possibly underlie their bioactivities. Therefore, thirty-three secondary metabolites were characterized, among them, sesquiterpenes and diterpenes were found to prevail. In silico modeling was carried out on the dereplicated compounds to provide an insight into their anti-trypanosomal mechanism of action with docking study on ornithine decarboxylase (ORD) which illustrated that five of the dereplicated compounds (‎2-deoxy-12-ethoxy-7-O-methyl lemnacarnol, Nephthenol, ‎4α-O-acetyl-selin-11-en, Eudesma-4,7(11)-diene-8β-ol, and Chabrolidione A) have the highest affinity to the ornithine decarboxylase enzyme. These results highlight the valuable chemical profile of Nephthea mollis as a lead source for anti-trypanosomal natural products.

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Polymeric Micelles in the Delivery of Therapeutic Phytoconstituents

Unde¹

2023

Polymeric Micelles: Principles, Perspectives and Practices

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The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity

Abstract: Mentha species are medicinally used worldwide and remain attractive for research due to the diversity of their phytoconstituents and large therapeutic indices for various ailments.

Cited by 9 publications

References 79 publications

Bazi Düzce Halk İlaçlarinin Ki̇motri̇psi̇n, Üreaz İnhi̇be Edi̇ci̇ Ve Anti̇oksi̇dan Akti̇vi̇teleri̇

Bazi Düzce Halk İlaçlarinin Ki̇motri̇psi̇n, Üreaz İnhi̇be Edi̇ci̇ Ve Anti̇oksi̇dan Akti̇vi̇teleri̇

Anti-Trypanosomal Potential of The Red Sea Soft Coral Nephthea Mollis Supported by Metabolomic Profiling and Molecular Docking Studies

Polymeric Micelles in the Delivery of Therapeutic Phytoconstituents

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