The metabolomic detection of lung cancer biomarkers in sputum

Cameron, Simon; Lewis, Keir; Beckmann, Manfred; Allison, Gordon; Ghosal, Robin; Lewis, Paul D.; Mur, Luis A. J.

doi:10.1016/j.lungcan.2016.02.006

Cited by 67 publications

(49 citation statements)

References 25 publications

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“…In our studies, we have 1) demonstrated the feasibility for assessing smoking-related biomarkers in blood and urine (134); 2) identified novel biomarkers related to smoking (e.g., glycophospholipids and pathways related to inhibition of cAMP), including some that differ by gender and race (117); and, 3) identified the presence of menthol metabolites (117). We are not aware of metabolomics studies in the lung for smoking-related changes, but metabolomics have shown changes in smokers’ sputum (135), and have been used in a bronchoscopy study for air pollution (136). …”

Section: Introductionmentioning

confidence: 99%

A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation

Shields

Berman

Brasky

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

110

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The use of electronic cigarettes (e-cigs) is increasing rapidly, but their effects on lung toxicity are largely unknown. Smoking is a well-established cause of lung cancer and respiratory disease, in part through inflammation. It is plausible that e-cig use might affect similar inflammatory pathways. E-cigs are used by some smokers as an aid for quitting or smoking reduction, and by never smokers (e.g., adolescents and young adults). The relative effects for impacting disease risk may differ for these groups. Cell culture and experimental animal data indicate that e-cigs have the potential for inducing inflammation, albeit much less than smoking. Human studies show that e-cig use in smokers is associated with substantial reductions in blood or urinary biomarkers of tobacco toxicants when completely switching and somewhat for dual use. However, the extent to which these biomarkers are surrogates for potential lung toxicity remains unclear. The FDA now has regulatory authority over e-cigs and can regulate product and e-liquid design features such as nicotine content and delivery, voltage, e-liquid formulations, and flavors. All of these factors may impact pulmonary toxicity. This review summarizes current data on pulmonary inflammation related to both smoking and e-cig use, with a focus on human lung biomarkers.

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Section: Introductionmentioning

confidence: 99%

A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation

Shields

Berman

Brasky

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

110

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“…Any subtle changes in metabolic pathway may lead to the development of abnormal cell or disease. For example, changes in expression of metabolites can lead to colorectal cancer (Brown et al (2016)) and lung cancer (Cameron et al (2016)).…”

Section: 4mentioning

confidence: 99%

Metabolic Pathway Membership Inference using an Ontology-based Similarity Approach

Cartealy

Liao

2019

Proceedings of the 2019 8th International Conference on Bioinformatics and Biomedical Science

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“…14,15 Therefore, how to early diagnose LC has become an important problem. 16,17 Metabolomics is a technology to study the metabolic pathway of biological system by investigating the changes of metabolites of biological system aer being stimulated or disturbed. 18 It is another important research content of system biology aer genomics, transcriptome and proteomics.…”

Section: Introductionmentioning

confidence: 99%

High-throughput untargeted metabolomics and chemometrics reveals pharmacological action and molecular mechanism of chuanxiong by ultra performance liquid chromatography combined with quadrupole-time-of-flight-mass spectrometry

Luo

Zhang

et al. 2019

RSC Adv.

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The metabolomic detection of lung cancer biomarkers in sputum

Cited by 67 publications

References 25 publications

A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation

A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation

Metabolic Pathway Membership Inference using an Ontology-based Similarity Approach

High-throughput untargeted metabolomics and chemometrics reveals pharmacological action and molecular mechanism of chuanxiong by ultra performance liquid chromatography combined with quadrupole-time-of-flight-mass spectrometry

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