It has appeared that public health’s goal of “prolonging life and promoting health” requires the eradication of causes for as long as each of the clinical outcomes which must be prevented and cured with precision for the achievement of this noble goal has been seen as the manifestation of a disease with one or more causes depending on whether the theory that accounts for the causation of this disease is mono-causal or multi-causal. But upon constructing biomedical and epidemiological concepts with a method that resolves the conceptual ambiguity that has hitherto surrounded the relationship between mono-causal and multi-causal theories of disease, the outcomes of pathological events were found to be the consequence of the co-manifestation of different diseases. And such outcomes were found to emerge from pathological events only when pathological mechanisms respond to all of such diseases and not merely because of the mere presence of the specific cause or a set of causes which, together, constitute the sufficient cause of any one of them. This result furnishes us with the capacity to resolve other conceptual ambiguities as well as the mode of thinking that should dominate ongoing research if the noble goals of epidemiology and public health will become reality in spite of our inability to eradicate causes.