The Michel Benoist and Robert Mulholland yearly European Spine Journal Review: a survey of the “medical” articles in the European Spine Journal, 2016

Benoist, M

doi:10.1007/s00586-016-4886-5

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…The number and function of these vascular buds determine the permeability of the vertebral bone-vertebral endplate-IVD interfaces [7,8]. Moreover, studies have reported a difference in the vascular architecture between the superior and inferior VEPs [9], and that there are more vascular buds distributed in the cranial endplate than in the caudal endplate [10]. At present, it is believed that the nutritional supply to the IVD comes primarily from diffusion through the vascular buds and the endplate path in the bone marrow contact channel [5,11].…”

Section: Introductionmentioning

confidence: 99%

Constant compression decreases vascular bud and VEGFA expression in a rabbit vertebral endplate ex vivo culture model

et al. 2020

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of background data The vascular buds in the vertebral endplate (VEP) are the structural foundation of nutrient exchange in the intervertebral disc (IVD). VEGF is closely related to angiogenesis in the endplate and intervertebral disc degeneration (IDD). Objective To investigate the effects of static load on vascular buds and VEGF expression in the VEP and to further clarify the relation between IDD and VEGF. Methods IVD motion segments were harvested from rabbit lumbar spines and cultured under no-loading conditions (controls) or in custom-made apparatuses under a constant compressive load (0.5 MPa) for up to 14 days. Tissue integrity and the number of vascular buds were determined, and the concentrations and expression of Aggrecan, COL2a1, and VEGFA in the VEPs were assessed after 3, 7, and 14 days of culturing and then compared with those of fresh tissues. Results Under the constant compression, the morphological integrity of the VEPs was gradually disrupted, and immunohistochemistry results showed a significant decrease in the levels of Agg and COL2a1. During the static load, the number of vascular buds in the VEPs was gradually reduced from the early stage of culture, and ELISA showed that the constant compressive load caused a significant decrease in the VEGFA and VEGFR2 protein concentrations, which were consistent with the immunohistochemistry results. Western blot and RT-PCR

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Section: Introductionmentioning

confidence: 99%

Constant compression decreases vascular bud and VEGFA expression in a rabbit vertebral endplate ex vivo culture model

et al. 2020

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Anterior Controllable Antedisplacement and Fusion (ACAF) Technique for the Treatment of Multilevel Cervical Spondylotic Myelopathy With Spinal Stenosis (MCSMSS)

Luo

Wang

Sun

et al. 2021

Clinical Spine Surgery: A Spine Publication

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Background To investigate the clinical effect of anterior controllable antedisplacement and fusion (ACAF)technique for the treatment of multilevel cervical spondylotic myelopathy with spinal stenosis (MCSMSS), and compare ACAF with hybrid decompression xation (HDF). Methods A retrospective analysis of 85 cases with MCSMSS was carried out. 45 patients were treated with ACAF, while 40 patients were treated with HDF. The operation time, intraoperative bleeding volume, postoperative complications, Japanese Orthopaedic Association (JOA) score, Neck Disability Index (NDI) score, Computed Tomography (CT) transverse measurement, cervical curvature and Kang's grade were compared between two groups. Results The patients were followed up for 12 to 17 months. Compared with HDF, ACAF group achieved better decompression according to CT measurement and Kang's grade (P < 0.05), and recovered to a greater cervical Cobb's angle (P < 0.05). However, JOA score and NDI index showed no signi cant difference one year after surgery (P 0.05). Additionally, ACAF presented longer operation time and greater intraoperative blood loss (P < 0.05). As to complications, ACAF developed less incidences of cerebrospinal uid examination (CSF) leakage, neurologic deterioration, epidural hematoma and C5 palsy by comparing with HDF. Conclusions ACAF is an effective method for the treatment of MCSMSS.Compared with HDF, ACAF has the advantages of signi cant decompression, increasing cervical curvature, and reducing the incidences of complications.

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The Michel Benoist and Robert Mulholland yearly European Spine Journal Review: a survey of the “medical” articles in the European Spine Journal, 2016

Cited by 2 publications

References 36 publications

Constant compression decreases vascular bud and VEGFA expression in a rabbit vertebral endplate ex vivo culture model

Constant compression decreases vascular bud and VEGFA expression in a rabbit vertebral endplate ex vivo culture model

Anterior Controllable Antedisplacement and Fusion (ACAF) Technique for the Treatment of Multilevel Cervical Spondylotic Myelopathy With Spinal Stenosis (MCSMSS)

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