The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress

Bear, Tracey; Dalziel, Julie E.; Coad, Jane; Roy, Nicole C.; Butts, Christine A.; Gopal, Pramod K.

doi:10.3390/microorganisms9040723

Cited by 73 publications

(55 citation statements)

References 191 publications

(190 reference statements)

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“…The stress-resilient animals had more Bifidobacterium spp as compared to stress-sensitive control mice. Since various Bifidobacterium strains are considered psychobiotic, a rise in their abundance in some of the rats appeared to increase stress resistance ( Bear et al, 2021 ).…”

Section: Psychobiotic Products and Impact On Mental Healthmentioning

confidence: 99%

Delving the role of nutritional psychiatry to mitigate the COVID-19 pandemic induced stress, anxiety and depression

Shabbir

Mehak²,

Khan³

et al. 2022

Trends in Food Science & Technology

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Background The distressing COVID-19 pandemic has had a substantial impact on public mental health, and the importance of food and nutrients in several aspects of mental health has been recognized. People in isolation or quarantine suffer from severe stress, anger, panic attack, and anxiety. Scope and approach Although, people who have improved and progressed through medications or vaccines have reduced anxiety levels to some extent yet the efficacy of these measures, in the long run, remains a question. The review depicts that such negative emotional reactions were particularly higher in elderly individuals in the first wave than in other phases. The emotional and behavioral response to the COVID-19 pandemic is multifactorial. From different research studies, it has been found that stress scores were considerably higher for those engaging in unhealthy eating practices. This factor relies not only on external components but on personal and innate ones as well. In the present pandemic, the sustainable development of the food system would have been a major issue; this should be carefully restored to avoid a food crisis in the future. Key findings and conclusions Changes in mind-body interactions are triggered by psychosocial stresses such as interpersonal loss and social rejection. Physiological response (in terms of psychological stress) in COVID-19 affected patients varies due to individual physical health status. This review explores the relationship between nutrition and mental health as what we eat and think is interlinked with the gut-brain-axis. The role of dietary components along with the Mediterranean diet, DASH diet and use of psychobiotics in improving psychological distress in pandemic induced stress, anxiety and depression has also been discussed.

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Section: Psychobiotic Products and Impact On Mental Healthmentioning

confidence: 99%

Delving the role of nutritional psychiatry to mitigate the COVID-19 pandemic induced stress, anxiety and depression

Shabbir

Mehak²,

Khan³

et al. 2022

Trends in Food Science & Technology

View full text Add to dashboard Cite

show abstract

“…Furthermore, other bacteria taxa, which were altered in our experimental approach, such as Escherichia coli and lactic acid bacteria have been found to also produce neurotransmitters such as serotonin [ 44 ] and GABA [ 45 ], respectively. Interestingly, it has been described an increment in opportunistic microbes [ 46 ] as in the case of some bacteria (e.g., Lactobacillus ) and some viruses (e.g., Herpesvirus order) as consequence of stressful events.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Metabolome and Microbiome Associated with an Early Stress Stage in Male Wistar Rats: A Multi-Omics Approach

Hernandez-Baixauli

Puigbò

Abasolo

et al. 2021

IJMS

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Stress disorders have dramatically increased in recent decades becoming the most prevalent psychiatric disorder in the United States and Europe. However, the diagnosis of stress disorders is currently based on symptom checklist and psychological questionnaires, thus making the identification of candidate biomarkers necessary to gain better insights into this pathology and its related metabolic alterations. Regarding the identification of potential biomarkers, omic profiling and metabolic footprint arise as promising approaches to recognize early biochemical changes in such disease and provide opportunities for the development of integrative candidate biomarkers. Here, we studied plasma and urine metabolites together with metagenomics in a 3 days Chronic Unpredictable Mild Stress (3d CUMS) animal approach that aims to focus on the early stress period of a well-established depression model. The multi-omics integration showed a profile composed by a signature of eight plasma metabolites, six urine metabolites and five microbes. Specifically, threonic acid, malic acid, alpha-ketoglutarate, succinic acid and cholesterol were proposed as key metabolites that could serve as key potential biomarkers in plasma metabolome of early stages of stress. Such findings targeted the threonic acid metabolism and the tricarboxylic acid (TCA) cycle as important pathways in early stress. Additionally, an increase in opportunistic microbes as virus of the Herpesvirales was observed in the microbiota as an effect of the primary stress stages. Our results provide an experimental biochemical characterization of the early stage of CUMS accompanied by a subsequent omic profiling and a metabolic footprinting that provide potential candidate biomarkers.

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“…The microbiome hypothesis describes the complex network structure of intestinal mucosa and the host-microbiome of depression patients, suggesting that depression is closely related to the intestinal microbiome, and that "gut microbiome-gut-brain" dysfunction is the primary pathological basis of depression. The abnormalities in this link may be the direct cause and potential influencing factors of depression, so the regulation of the microbiome may be an effective way to prevent and treat depression [5].…”

Section: Introductionmentioning

confidence: 99%

Maintaining the Balance of Intestinal Flora through the Diet: Effective Prevention of Illness

Zhang

et al. 2021

Foods

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The human body is home to a complex community of dynamic equilibrium microbiota, including bacteria, fungi, parasites, and viruses. It is known that the gut microbiome plays a crucial role in regulating innate and adaptive immune responses, intestinal peristalsis, intestinal barrier homeostasis, nutrient uptake, and fat distribution. The complex relationship between the host and microbiome suggests that when this relationship is out of balance, the microbiome may contribute to disease development. The brain–gut–microbial axis is composed of many signal molecules, gastrointestinal mucosal cells, the vagus nerve, and blood–brain barrier, which plays an essential role in developing many diseases. The microbiome can influence the central nervous system function through the brain–gut axis; the central nervous system can also affect the composition and partial functions of the gut microbiome in the same way. Different dietary patterns, specific dietary components, and functional dietary factors can significantly affect intestinal flora’s structure, composition, and function, thereby affecting human health. Based on the above, this paper reviewed the relationship between diet, intestinal flora, and human health, and the strategies to prevent mental illness through the dietary modification of intestinal microorganisms.

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The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress

Cited by 73 publications

References 191 publications

Delving the role of nutritional psychiatry to mitigate the COVID-19 pandemic induced stress, anxiety and depression

Delving the role of nutritional psychiatry to mitigate the COVID-19 pandemic induced stress, anxiety and depression

Alterations in Metabolome and Microbiome Associated with an Early Stress Stage in Male Wistar Rats: A Multi-Omics Approach

Maintaining the Balance of Intestinal Flora through the Diet: Effective Prevention of Illness

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