The Microvascular Phases of Metastasis

Weiss, Leonard; Orr, F. W.

doi:10.1007/978-1-4899-0721-9_27

Cited by 4 publications

(1 citation statement)

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“…Lymphatics and blood vessels are major anatomical pathways for cancer cell dissemination and account for the location of cancer metastases at sites that are distant from their primary tumour1. Within blood vessels, circulating tumour cells interact with humoral and cellular constituents of blood and with the endothelial cells of blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Interactions between cancer cells and the endothelium in metastasis

et al. 2000

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The haematogenous phase of cancer metastasis facilitates the transport of metastatic cells within the blood and incorporates a sequence of interactions between circulating intravascular cancer cells and the endothelium of blood vessels at the sites of tumour cell arrest. Initial interactions involve mechanical contact and transient adhesion, mediated by endothelial selectins and their ligands on the neoplastic cells. This contact initiates a sequence of activation pathways that involves cytokines, growth factors, bioactive lipids, and reactive oxygen species produced by either the cancer cell or the endothelium. These molecules elicit expression of integrin adhesion molecules in cancer cells and the endothelium, matrix metalloproteinases, and chemotactic factors that promote the attachment of tumour cells to the vessel wall and/or transvascular penetration. Induction of endothelial free radicals can be cytotoxic to cancer cells. Collectively, the sum of these interactions constitutes an interdependent relationship, the outcome of which determines the fate of the metastatic process. Copyright © 2000 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%